| Assay ID | Title | Year | Journal | Article |
|---|
| AID1346743 | Human Retinoid X receptor-beta (2B. Retinoid X receptors) | 2009 | Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
| Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. |
| AID1346763 | Mouse Retinoid X receptor-alpha (2B. Retinoid X receptors) | 2005 | The Journal of biological chemistry, Jan-14, Volume: 280, Issue:2
| Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies. |
| AID1347157 | Confirmatory screen GU Rhodamine qHTS for Zika virus inhibitors qHTS | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347156 | DAPI mCherry counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347172 | Secondary qRT-PCR qHTS assay for selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347158 | ZIKV-mCherry secondary qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347164 | 384 well plate NINDS Rhodamine confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347163 | 384 well plate NINDS AMC confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347170 | Vero cells viability counterscreen for qRT-PCR qHTS assay of selected Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID350576 | Activity at RARalpha/RXRalpha ligand binding domain assessed as stabilization of RXR helix H12 by fluorescence anisotropy | 2009 | Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
| Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. |
| AID1069740 | Antagonist activity at recombinant GST-tagged RXRalpha LBD (unknown origin) assessed as inhibition of CD3254-induced fluorescein labeled D22 coactivator recruitment at 8 uM after 4 hrs by TR-FRET assay | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID1069744 | Agonist activity at recombinant GST-tagged RXRalpha LBD (unknown origin) assessed as induction of fluorescein labeled D22 coactivator recruitment after 4 hrs by TR-FRET assay relative to control | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID1069750 | Agonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as induction of transcriptional activity at 4 uM after 6 hrs by luciferase/beta-galactosidase reporter gene assay relative to control | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID1069748 | Antagonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as ATRA-induced transcriptional activity at 4 uM by luciferase/beta-galactosidase reporter gene assay relative to ATRA-treated control | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID1069743 | Agonist activity at recombinant GST-tagged RXRalpha LBD (unknown origin) assessed as induction of biotinylated SRC-1-676-700 coactivator recruitment after 4 hrs by TR-FRET assay (Rvb = 148 +/- 7%) | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID420857 | Inhibition of Gal4-LBD fused mouse RXRalpha transactivation in african green monkey CV1 cells at 1 uM after 6 hrs by Dual-light chemiluminescent assay | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6
| Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles. |
| AID1069747 | Antagonist activity at Gal4-fused RXRalpha (unknown origin) transfected in HEK293 cells assessed as CD3254-induced transcriptional activity at 4 uM by luciferase/beta-galactosidase reporter gene assay relative to CD3254-treated control | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID350581 | Antagonist activity at Gal4-tagged human RXRbeta receptor expressed in human HeLa cells assessed as inhibition of CD3254-induced transcription at 1 uM by luciferase reporter assay | 2009 | Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
| Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. |
| AID1069749 | Agonist activity at Gal4-fused RXRalpha (unknown origin) transfected in HEK293 cells assessed as induction of transcriptional activity at 4 uM after 24 hrs by luciferase/beta-galactosidase reporter gene assay relative to control | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID350580 | Activity at RARalpha/RXRalpha ligand binding domain assessed as stabilization of RXR helix H12 by fluorescence anisotropy in presence of up to 10 uM coactivator peptide TIF-NR2 | 2009 | Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
| Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. |
| AID1185333 | Antagonist activity against RXRalpha V298S mutant (unknown origin) expressed in human HEK293T cells assessed as inhibition of 9-cis-RA-induced receptor transactivation at 1 uM after 18 hrs by luciferase reporter gene based mammalian one-hybrid assay | 2014 | ACS medicinal chemistry letters, Jul-10, Volume: 5, Issue:7
| Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site. |
| AID350578 | Activity at Gal4-tagged human RXRbeta receptor expressed in human HeLa cells assessed as relative transcriptional activity by luciferase reporter assay relative to CD3254 | 2009 | Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
| Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |