| Assay ID | Title | Year | Journal | Article |
|---|
| AID1069743 | Agonist activity at recombinant GST-tagged RXRalpha LBD (unknown origin) assessed as induction of biotinylated SRC-1-676-700 coactivator recruitment after 4 hrs by TR-FRET assay (Rvb = 148 +/- 7%) | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID1069748 | Antagonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as ATRA-induced transcriptional activity at 4 uM by luciferase/beta-galactosidase reporter gene assay relative to ATRA-treated control | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID1069750 | Agonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as induction of transcriptional activity at 4 uM after 6 hrs by luciferase/beta-galactosidase reporter gene assay relative to control | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID1069749 | Agonist activity at Gal4-fused RXRalpha (unknown origin) transfected in HEK293 cells assessed as induction of transcriptional activity at 4 uM after 24 hrs by luciferase/beta-galactosidase reporter gene assay relative to control | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID1525213 | Binding affinity to recombinant human RXRalpha LBD (592 to 1386 residues) expressed in Escherichia coli BL21 (DE3) by fluorescence quenching assay | 2019 | Journal of natural products, 05-24, Volume: 82, Issue:5
| Cytotoxic Components from Hypericum elodeoides Targeting RXRα and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage. |
| AID1069744 | Agonist activity at recombinant GST-tagged RXRalpha LBD (unknown origin) assessed as induction of fluorescein labeled D22 coactivator recruitment after 4 hrs by TR-FRET assay relative to control | 2014 | Bioorganic & medicinal chemistry, Feb-15, Volume: 22, Issue:4
| Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids. |
| AID350577 | Activity at RARalpha/RXRalpha ligand binding domain assessed as stabilization of RXR helix H12 by fluorescence anisotropy in presence of 1 uM coactivator peptide TIF-NR2 | 2009 | Journal of medicinal chemistry, May-28, Volume: 52, Issue:10
| Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |