hemanthidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

hemanthidine: crinine-like alkaloid from AMARYLLIDACEAE [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Amaryllidaceae	family	A family of herbaceous plants with bulbs or rhizomes in the order Asparagales.[MeSH]	Amaryllidaceae	A family of herbaceous plants with bulbs or rhizomes in the order Asparagales.[MeSH]

Cross-References

ID Source	ID
PubMed CID	544807
MeSH ID	M0223110

Synonyms (9)

Synonym
hemanthidine
crinan-6,11-diol, 1,2-didehydro-3-methoxy-, (3beta,5alpha,6beta,11r,13beta,19alpha)-
3h,6h-5,11b-ethano[1,3]dioxolo[4,5-j]phenanthridine, crinan-6,11-diol deriv.
crinan-6,11-diol, 1,2-didehydro-3-methoxy-, (3.beta.,5.alpha.,6.beta.,11r,13.beta.,19.alpha.)-
4a.beta.,5.alpha.,11b.alpha.-crinan-6.beta.,12-diol, 1,2-didehydro-3.beta.-methoxy-, (12r)-
3-methoxy-1,2-didehydrocrinan-6,11-diol #
crinan-7,18-diol, 1,2-didehydro-3-methoxy-, (3.beta.,5.beta.,6.alpha.,7.beta.,17.alpha.,18r)-
ZSTPNQLNQBRLQF-UHFFFAOYSA-N
15-methoxy-5,7-dioxa-12-azapentacyclo[10.5.2.01,13.02,10.04,8]nonadeca-2,4(8),9,16-tetraene-11,18-diol

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (12.50)	18.2507
2000's	3 (37.50)	29.6817
2010's	4 (50.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.39 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.59 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.39)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	2.01	1	aromatic ether; nitrile; polyether; tertiary amino compound
metolachlor metolachlor: structure given in first source. metolachlor : A racemate that consists of equimolar amounts of (R)- and (S)-metolachlor.. 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(1-methoxypropan-2-yl)acetamide : An organochlorine compound that is 2-chloroacetamide substituted by a (2-ethyl-6-methylphenyl)-N-(1-methoxypropan-2-yl) group at the nitrogen atom.	2.17	1	aromatic amide; benzenes; ether; organochlorine compound
cyclohexene cyclohexene : A cycloalkene that is cylohexane with a single double bond.	2.02	1	cycloalkene
galantamine Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.	2.08	1	benzazepine alkaloid fundamental parent; benzazepine alkaloid; organic heterotetracyclic compound; tertiary amino compound	antidote to curare poisoning; cholinergic drug; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; plant metabolite
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.02	1	metal allergen; nickel group element atom; platinum group metal atom
lycorine lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.	2.43	2	indolizidine alkaloid	anticoronaviral agent; antimalarial; plant metabolite; protein synthesis inhibitor
pretazettine pretazettine: potent inhibitor of viral reverse transcriptase; narcissus alkaloid; prolongs life of leukemic mice; RN given refers to (6a beta,8 beta)-isomer; structure	2.7	3	alkaloid
hippeastrine hippeastrine: isolated from Amaryllidaceae; structure given in first source; RN given refers to (5alpha)-isomer. hippeastrine : An indole alkaloid isolated from the Amaryllidaceae family and has been shown to exhibit cytotoxic activity.	1.98	1	delta-lactone; indole alkaloid; organic heteropentacyclic compound; secondary alcohol	antineoplastic agent; metabolite
trispheridine trispheridine: structure in first source	2.01	1	phenanthridines
pseudolycorine pseudolycorine: alkaloid isolated from Narcissus tazetta var. chinensis Roem, N. papyraceus or Lycoris radiata Herb; structure in first source	2.05	1	phenanthridines
tazettine tazettine: from Amaryllidaceae	2.69	3	indole alkaloid fundamental parent; indole alkaloid
crinamine crinamine: RN given for (3alpha,5alpha,11R,13beta,19alpha)-isomer; structure in first source	2.02	1
nifedipine hemanthamine: crinine-like alkaloid from AMARYLLIDACEAE; RN given for (3beta,5alpha,11R,13beta,19alpha)-isomer; structure in first source	2.98	4

Condition	Relationship Strength	Studies
Acute Confusional Senile Dementia [description not available]	2.08	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.08	1
Palsy [description not available]	2.08	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.08	1
Paralysis A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)	2.08	1
Leucocythaemia [description not available]	2.1	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2.1	1
Leukemia L5178 An experimental lymphocytic leukemia of mice.	2.01	1

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