Page last updated: 2024-09-04

tripitramine and pirenzepine

tripitramine has been researched along with pirenzepine in 7 studies

Compound Research Comparison

Studies
(tripitramine)
Trials
(tripitramine)
Recent Studies (post-2010)
(tripitramine)
Studies
(pirenzepine)
Trials
(pirenzepine)
Recent Studies (post-2010) (pirenzepine)
17003,812587140

Protein Interaction Comparison

ProteinTaxonomytripitramine (IC50)pirenzepine (IC50)
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.6891
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.5856
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.6134
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.6222
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.6227
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.6227
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.3406
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.6281
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.0291
Muscarinic acetylcholine receptor M1Mus musculus (house mouse)0.75
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.9556
Muscarinic acetylcholine receptor M4Mus musculus (house mouse)0.75
Muscarinic acetylcholine receptor M5Mus musculus (house mouse)0.75
Muscarinic acetylcholine receptor M3Mus musculus (house mouse)0.75
Muscarinic acetylcholine receptor M2Mus musculus (house mouse)0.51

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (85.71)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bolognesi, ML; Budriesi, R; Canossa, M; Chiarini, A; Melchiorre, C; Minarini, A; Spampinato, S1
Bolognesi, ML; Chiarini, A; Melchiorre, C; Minarini, A; Spampinato, S1
Bellucci, C; Bolognesi, ML; Giorgi, G; Marucci, G; Matera, R; Melchiorre, C; Minarini, A; Rosini, M; Tumiatti, V1
Angeli, P; Bianchi, S; Imeri, L; Mancia, M1
Potter, LT; Purkerson, SL1
Brown, DA; Caulfield, MP; Fernandez-Fernandez, JM; Halley, P; Wanaverbecq, N1
Budriesi, R; Chiarini, A; Melchiorre, C; Minarini, A; Spampinato, S; Tumiatti, V1

Other Studies

7 other study(ies) available for tripitramine and pirenzepine

ArticleYear
Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed b
    Journal of medicinal chemistry, 1994, Sep-30, Volume: 37, Issue:20

    Topics: Animals; Atrial Function; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Drug Design; Female; Guinea Pigs; Heart Atria; Ileum; Male; Molecular Structure; Muscarinic Antagonists; Muscle Contraction; Myocardial Contraction; Myocardium; Polyamines; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Submandibular Gland

1994
Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists.
    Journal of medicinal chemistry, 1993, Nov-12, Volume: 36, Issue:23

    Topics: Animals; Benzodiazepines; Diamines; Guinea Pigs; Molecular Structure; Muscarinic Antagonists; Rats; Receptors, Muscarinic; Structure-Activity Relationship

1993
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.
    Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15

    Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexylamines; Gene Expression Regulation; Guinea Pigs; Heart Atria; Humans; Male; Models, Molecular; Molecular Structure; Muscarinic Antagonists; Muscle, Skeletal; Pirenzepine; Protein Binding; Quinoxalines; Rabbits; Receptors, Muscarinic; Structure-Activity Relationship; Vas Deferens

2008
Muscarinic receptor subtypes in the medial preoptic area and sleep-wake cycles.
    Neuroreport, 1996, Jan-31, Volume: 7, Issue:2

    Topics: Animals; Benzodiazepines; Body Temperature Regulation; Male; Microinjections; Muscarinic Antagonists; Piperidines; Pirenzepine; Preoptic Area; Rats; Receptors, Muscarinic; Sleep; Sleep, REM; Wakefulness

1996
Use of antimuscarinic toxins to facilitate studies of striatal m4 muscarinic receptors.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2

    Topics: Alkaloids; Animals; Benzodiazepines; Binding, Competitive; Cats; CHO Cells; Corpus Striatum; Cricetinae; Elapid Venoms; Furans; Gallamine Triethiodide; Humans; Male; Muscarinic Antagonists; N-Methylscopolamine; Naphthalenes; Neurotoxins; Piperidines; Pirenzepine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Receptors, Muscarinic; Recombinant Proteins

1998
Selective activation of heterologously expressed G protein-gated K+ channels by M2 muscarinic receptors in rat sympathetic neurones.
    The Journal of physiology, 1999, Mar-15, Volume: 515 ( Pt 3)

    Topics: Animals; Barium; Benzodiazepines; Biolistics; Calcium Channels; Carbachol; Cells, Cultured; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Green Fluorescent Proteins; GTP-Binding Proteins; Luminescent Proteins; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pirenzepine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M4; Receptors, Muscarinic; Recombinant Proteins; Superior Cervical Ganglion; Transfection

1999
The design of novel methoctramine-related tetraamines as muscarinic receptor subtype selective antagonists.
    Life sciences, 1995, Volume: 56, Issue:11-12

    Topics: Animals; Atrial Function; Benzodiazepines; Benzodiazepinones; Diamines; Drug Design; Guinea Pigs; Heart Atria; Ileum; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Pirenzepine; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Submandibular Gland; Trachea

1995