thymidine diphosphate-l-rhamnose profile

Thymidine diphosphate-l-rhamnose (TDP-l-Rha) is an essential nucleotide sugar involved in the biosynthesis of various polysaccharides, including the O-antigens of bacterial lipopolysaccharides, the capsular polysaccharides of some bacteria, and the cell wall polysaccharides of plants. Its synthesis involves the activation of l-rhamnose by phosphorylation to l-rhamnose 1-phosphate, followed by the transfer of the phosphate group to thymidine diphosphate (TDP). The resulting TDP-l-Rha is then used as a substrate for various glycosyltransferases that incorporate l-rhamnose into polysaccharides. Research on TDP-l-Rha focuses on its role in bacterial pathogenesis and its potential as a target for antimicrobial agents. Additionally, understanding TDP-l-Rha biosynthesis and its role in plant cell wall formation is important for agricultural applications, such as improving plant resistance to pathogens and enhancing crop yield.'

dTDP-beta-L-rhamnose : The beta-anomer of dTDP-L-rhamnose. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	121966
CHEBI ID	15774
SCHEMBL ID	1533809
MeSH ID	M0198214

Synonym
thymidine diphosphate rhamnose
thymidine 5'-[3-(6-deoxy-beta-l-mannopyranosyl) dihydrogen diphosphate]
thymidine 5'-(trihydrogen diphosphate), p'-(6-deoxy-beta-l-mannopyranosyl) ester
2147-59-3
CHEBI:15774
thymidine diphosphate-l-rhamnose
2'-deoxy-thymidine-beta-l-rhamnose
dtdp-6-deoxy-beta-l-mannose
C03319
dtdp-beta-l-rhamnose
dtdp-l-rhamnose
dtdp-6-deoxy-l-mannose
DB03723
[hydroxy-[[(2r,3s,5r)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] [(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl] hydrogen phosphate
SCHEMBL1533809
DTXSID50175752
deoxythymidine diphosphate-l-rhamnose
[(2r,3s,5r)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)tetrahydrofuran-2-yl]methyl (2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yl dihydrogen diphosphate (non-preferred name)
Q27098225
dtdp l-rhamnose
PD059501

Role	Description
Escherichia coli metabolite	Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
dTDP-L-rhamnose
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (15.38)	18.7374
1990's	15 (23.08)	18.2507
2000's	24 (36.92)	29.6817
2010's	14 (21.54)	24.3611
2020's	2 (3.08)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	65 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phenol [no description available]	2	1	phenols	antiseptic drug; disinfectant; human xenobiotic metabolite; mouse metabolite
thymidine [no description available]	8.19	6	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
chloramphenicol Amphenicol: Chloramphenicol and its derivatives.	2.15	1	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor
sucrose Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.	2.02	1	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent
galactose galactopyranose : The pyranose form of galactose.	1.98	1	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
carbostyril Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.	2.15	1	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	2.17	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
thymidine monophosphate Thymidine Monophosphate: 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety.. dTMP : The neutral species of thymidine 5'-monophosphate (2'-deoxythymidine 5'-monophosphate).	2.02	1	thymidine 5'-monophosphate	fundamental metabolite
3-hydroxyflavone 3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.	2.13	1	flavonols; monohydroxyflavone
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	2.03	1	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
uridine diphosphate glucuronic acid Uridine Diphosphate Glucuronic Acid: A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones.. UDP-alpha-D-glucuronic acid : A UDP-sugar having alpha-D-glucuronic acid as the sugar component.	2	1	UDP-D-glucuronic acid	Escherichia coli metabolite; human metabolite; mouse metabolite
mannose mannopyranose : The pyranose form of mannose.	1.93	1	D-aldohexose; D-mannose; mannopyranose	metabolite
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	2.11	1	N-acetyl-D-glucosamine	epitope
deuterium oxide Deuterium Oxide: The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.	2	1	deuterated compound; water	NMR solvent
galactose aldohexose : A hexose with a (potential) aldehyde group at one end.	2.66	3
rhamnose [no description available]	3.76	11	L-rhamnose
6-deoxyglucose 6-deoxyglucose: RN given refers to (D)-isomer; Main Heading DEOXYGLUCOSE refers to 2-deoxyglucose	2.38	2	quinovose
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	2.38	2
6-deoxytalose 6-deoxytalose: RN given refers to (L)-isomer	2.06	1
6-deoxyaltrose 6-deoxyaltrose: RN given is for 6-deoxy-D-altrose; RN for parent cpd not in Chemline 11/93; Yersinia enterocolitica O antigen is a homopolymer of 6-deoxy-L-altrose. 6-deoxyaltrose : Any deoxyaltrose in which the hydroxy group at position 6 has been replaced by a hydrogen.	1.98	1
uridine diphosphate n-acetylmannosamine [no description available]	2	1	UDP-amino sugar
nadp [no description available]	2.44	2
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	2.42	2	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
mannans [no description available]	2.05	1
glycolipids [no description available]	2.03	1
novobiocin Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189). novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus.	2.02	1	carbamate ester; ether; hexoside; hydroxycoumarin; monocarboxylic acid amide; monosaccharide derivative; phenols	antibacterial agent; antimicrobial agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Escherichia coli metabolite; hepatoprotective agent

thymidine diphosphate-l-rhamnose

Description

Cross-References

Synonyms (21)

Roles (1)

Drug Classes (1)

Research

Studies (65)

Market Indicators

Research Demand Index: 10.45

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