Compounds > thuringiensin
Page last updated: 2024-11-12

thuringiensin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

thuringiensin: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID20056441
SCHEMBL ID118874
MeSH IDM0186845

Synonyms (19)

Synonym
thuringiensin
beta-exotoxin (bacillus thuringiensis)
d-allaric acid, o-5'-deoxyadenosinyl-(5'-4)-o-3,6-anhydro-alpha-d-glucopyranosyl-(1-2)-, 4-(dihydrogenphosphate)
nsc 197177
bacillus thuringiensis exotoxin
thuringiensin a
d-allaric acid, 2-o-alpha-d-glucopyranosyl-, 4-(dihydrogen phosphate), 4'-5'-anhydride with adenosine
thurintox
2-[(2r,3r,4r,5s,6r)-5-[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid
turingin-1 [russian]
unii-jbu770v87c
turingin-1
d-allaric acid, o-5'-deoxyadenosin-5'-yl-(5'.fwdarw.4)-o-alpha-d-glucopyranosyl-(1.fwdarw.2)-, 4-(dihydrogen phosphate)
jbu770v87c ,
SCHEMBL118874
.beta.-exotoxin (bacillus thuringiensis)
d-allaric acid, o-5'-deoxyadenosin-5'-yl-(5'->4)-o-.alpha.-d-glucopyranosyl-(1->2)-, 4-(dihydrogen phosphate
(2r,3s,4s,5s)-2-[(2r,3r,4r,5s,6r)-5-[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid
Q27281428

Research Excerpts

Overview

Thuringiensin is a thermostable secondary metabolite in Bacillus thuringiensis and has insecticidal activity against a wide range of insects.

ExcerptReferenceRelevance
"Thuringiensin is a thermostable secondary metabolite in Bacillus thuringiensis and has insecticidal activity against a wide range of insects. "( Genome-wide screening reveals the genetic determinants of an antibiotic insecticide in Bacillus thuringiensis.
Cao, SY; Hu, ZF; Liu, XY; Liu, Y; Peng, DH; Ruan, LF; Sun, M; Yu, ZN; Zheng, JS, 2010)		1.8

Toxicity

ExcerptReferenceRelevance
" The strains were of serotype H-1, producing thuringiensin, toxic to flies, and serotype H-14, producing endotoxin, toxic to mosquitoes, but not thuringiensin."( Safety testing of Bacillus thuringiensis preparations, including thuringiensin, using the Salmonella assay.
Abdel-Hameed, AH; Carlberg, G; Tikkanen, L, 1995)		0.79

Dosage Studied

ExcerptRelevanceReference
" The dosage of 360 units/mL penicillin-G had only a modest effect on the growth of the microorganism."( Penicillin-G enhanced production of thuringiensin by Bacillus thuringiensis sp. darmstadiensis.
Tzeng, YM; Young, YH, )		0.41
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (34)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's9 (26.47)18.2507
2000's20 (58.82)29.6817
2010's5 (14.71)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.16 (24.57)
Research Supply Index3.61 (2.92)
Research Growth Index4.47 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.78%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other35 (97.22%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetone
methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).		210ketone body;
methyl ketone;
propanones;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent
adenine
[no description available]		2.03106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
formic acid
formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.		2.4420monocarboxylic acidantibacterial agent;
astringent;
metabolite;
protic solvent;
solvent
hydroxyproline
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.		2.01104-hydroxyproline;
L-alpha-amino acid zwitterion		human metabolite;
mouse metabolite;
plant metabolite
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.		6.9910adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
acetonitrile
acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.		210aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		10.97340adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.99101,2-diacyl-sn-glycero-3-phosphocholine
ConditionIndicatedRelationship StrengthStudiesTrials
Disease, Pulmonary
[description not available]		02.4220
Centriacinar Emphysema
[description not available]		02.0110
Alveolitis, Fibrosing
[description not available]		02.0110
Lung Diseases
Pathological processes involving any part of the LUNG.		02.4220
Pulmonary Fibrosis
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.		02.0110
Diarrhea
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.		01.9910
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9910