sag-compound and purmorphamine

sag-compound has been researched along with purmorphamine* in 2 studies

Other Studies

2 other study(ies) available for sag-compound and purmorphamine

Article	Year
Structural insight into small molecule action on Frizzleds. Nature communications, 2020, 01-21, Volume: 11, Issue:1 WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, stem cell regulation and tissue homeostasis. FZDs are linked to severe human pathology and are seen as a promising target for therapy. Despite intense efforts, no small molecule drugs with distinct efficacy have emerged. Here, we identify the Smoothened agonist SAG1.3 as a partial agonist of FZD Topics: Cell Membrane; Dishevelled Proteins; Drug Discovery; Frizzled Receptors; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Targeted Therapy; Morpholines; Proof of Concept Study; Protein Interaction Domains and Motifs; Purines; Pyridines; Smoothened Receptor; Structure-Activity Relationship; Thiophenes; Wnt Signaling Pathway	2020
Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nature chemical biology, 2006, Volume: 2, Issue:1 Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway. Topics: Animals; Cell Membrane; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Hedgehog Proteins; Mice; Morpholines; NIH 3T3 Cells; Osteoblasts; Purines; Receptors, G-Protein-Coupled; Signal Transduction; Smoothened Receptor; Stem Cells; Tissue Engineering; Trans-Activators; Veratrum Alkaloids	2006

Article

Year

Structural insight into small molecule action on Frizzleds.

Nature communications, 2020, 01-21, Volume: 11, Issue:1

WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, stem cell regulation and tissue homeostasis. FZDs are linked to severe human pathology and are seen as a promising target for therapy. Despite intense efforts, no small molecule drugs with distinct efficacy have emerged. Here, we identify the Smoothened agonist SAG1.3 as a partial agonist of FZD

Topics: Cell Membrane; Dishevelled Proteins; Drug Discovery; Frizzled Receptors; HEK293 Cells; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Targeted Therapy; Morpholines; Proof of Concept Study; Protein Interaction Domains and Motifs; Purines; Pyridines; Smoothened Receptor; Structure-Activity Relationship; Thiophenes; Wnt Signaling Pathway

2020

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Nature chemical biology, 2006, Volume: 2, Issue:1

Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.

Topics: Animals; Cell Membrane; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Hedgehog Proteins; Mice; Morpholines; NIH 3T3 Cells; Osteoblasts; Purines; Receptors, G-Protein-Coupled; Signal Transduction; Smoothened Receptor; Stem Cells; Tissue Engineering; Trans-Activators; Veratrum Alkaloids

2006