monanchocidin: from the marine sponge Monanchora; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 49794528 |
| CHEMBL ID | 1822161 |
| CHEBI ID | 69398 |
| MeSH ID | M0552718 |
| Synonym |
|---|
| CHEMBL1822161 |
| chebi:69398 , |
| monanchocidin a |
| monanchocidin |
| monanchocidin a, rel- |
| Q27137737 |
| agjookrgjxjxte-saafptposa-n |
Monanchocidin A is a novel alkaloid recently isolated from the marine sponge Monanchora pulchra. It contains an unusual highly oxidized morpholinone fragment.
| Role | Description |
|---|---|
| metabolite | Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| organic molecular entity | Any molecular entity that contains carbon. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| acetylcholine receptor subunit alpha precursor | Mus musculus (house mouse) | IC50 (µMol) | 4.1000 | 4.1000 | 4.1000 | 4.1000 | AID743368 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | Ki | 8.0000 | 0.0027 | 9.3596 | 34.0000 | AID743370 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | Ki | 8.0000 | 0.0027 | 11.7538 | 34.0000 | AID743370 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | Ki | 8.0000 | 0.0027 | 11.7538 | 34.0000 | AID743370 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | Ki | 8.0000 | 0.0001 | 10.0747 | 34.0000 | AID743370 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Ki | 2.5000 | 0.0001 | 1.8811 | 28.0000 | AID743369 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID743370 | In vitro ability to inhibit the binding of [125I]alpha-bungarotoxin to Nicotinic acetylcholine receptor on membranes prepared from the electric organs of Torpedo californica | 2014 | Marine drugs, Mar-28, Volume: 12, Issue:4 | Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: from computer modeling to binding studies and electrophysiology. |
| AID743368 | Inhibition of functional activity of Mus musculus muscle nicotinic acetylcholine receptor expressed in Xenopus oocytes | 2014 | Marine drugs, Mar-28, Volume: 12, Issue:4 | Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: from computer modeling to binding studies and electrophysiology. |
| AID743369 | Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBP | 2014 | Marine drugs, Mar-28, Volume: 12, Issue:4 | Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: from computer modeling to binding studies and electrophysiology. |
| AID1478818 | Inhibition of eIF5A-1 (unknown origin) at 1 uM | 2017 | Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11 | Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids. |
| AID616387 | Cytotoxicity against human HL60 cells after 72 hrs by MTS assay | 2011 | Journal of natural products, Sep-23, Volume: 74, Issue:9 | Monanchocidins B-E: polycyclic guanidine alkaloids with potent antileukemic activities from the sponge Monanchora pulchra. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (9.09%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (90.91%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||