leucinostatin-a and 3-hydroxybutanal

leucinostatin-a has been researched along with 3-hydroxybutanal* in 1 studies

Other Studies

1 other study(ies) available for leucinostatin-a and 3-hydroxybutanal

Article	Year
Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A: A Modulator of Tumor-Stroma Interaction. Chemistry (Weinheim an der Bergstrasse, Germany), 2017, Sep-04, Volume: 23, Issue:49 Total synthesis of leucinostatin A, a modulator of tumor-stroma interactions, using asymmetric catalyses, a nitroaldol reaction, thioamide-aldol reaction, Strecker-type reaction, and alcoholysis of 3-methylglutaric anhydride, is described. We demonstrated the applicability of the established catalytic asymmetric processes to the synthesis of molecules with a complex structure. Careful analysis of the NMR data, HPLC profiles, and biological activity revealed that the correct structure of leucinostatin A is the epimeric form of the reported structure; the secondary alcohol within the AHMOD residue has an R configuration. Topics: Aldehydes; Antimicrobial Cationic Peptides; Catalysis; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Humans; Magnetic Resonance Spectroscopy; Peptides; Stereoisomerism; Thioamides	2017

Article

Year

Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A: A Modulator of Tumor-Stroma Interaction.

Chemistry (Weinheim an der Bergstrasse, Germany), 2017, Sep-04, Volume: 23, Issue:49

Total synthesis of leucinostatin A, a modulator of tumor-stroma interactions, using asymmetric catalyses, a nitroaldol reaction, thioamide-aldol reaction, Strecker-type reaction, and alcoholysis of 3-methylglutaric anhydride, is described. We demonstrated the applicability of the established catalytic asymmetric processes to the synthesis of molecules with a complex structure. Careful analysis of the NMR data, HPLC profiles, and biological activity revealed that the correct structure of leucinostatin A is the epimeric form of the reported structure; the secondary alcohol within the AHMOD residue has an R configuration.

Topics: Aldehydes; Antimicrobial Cationic Peptides; Catalysis; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Humans; Magnetic Resonance Spectroscopy; Peptides; Stereoisomerism; Thioamides

2017