| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine. | 2.15 | 1 | 0 | acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid | antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary |
streptomycin
[no description available] | 2.11 | 1 | 0 | antibiotic antifungal drug;
antibiotic fungicide;
streptomycins | antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor |
chrysomycin a
chrysomycin A: Streptomyces arenae; differs only in sugar moiety from gilvocarcin V | 3.17 | 1 | 0 | glycoside | |
tetrangulol
tetrangulol: structure in first source. tetrangulol : A member of the class of tetraphenes that is tetraphene-7,12-dione substituted by hydroxy groups at positions 1 and 8 and a methyl group at position 3. | 2.07 | 1 | 0 | p-quinones;
phenols;
tetraphenes | bacterial metabolite |
ay 25545
ravidomycin: isolated from mycelium of Streptomyces ravidus; structure given in first source. ravidomycin : A C-glycosylated naphthoisochromene derivative obtained from Streptomyces ravidus; exhibits antibiotic and anticancer properties. | 3.17 | 1 | 0 | acetate ester;
aromatic ether;
C-glycosyl compound;
naphthoisochromene;
olefinic compound;
phenols;
tertiary amine | antimicrobial agent;
antineoplastic agent;
bacterial metabolite |
glycosides
[no description available] | 3.55 | 2 | 0 | | |
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups. | 4.06 | 4 | 0 | | |
landomycin a
landomycin A: structure given in first source; isolated from Streptomyces sp. | 4.54 | 7 | 0 | oligosaccharide | metabolite |
gilvocarcin v
gilvocarcin V: from Actinomycete DO-38; structure given in first source | 3.17 | 1 | 0 | | |
jadomycin a
jadomycin A: the aglycone of jadomycin B; structure in first source. jadomycin A : A organic heteropentacyclic compound that is 1,2,8,13-tetrahydro-3aH-benzo[b][1,3]oxazolo[3,2-f]phenanthridine which carries oxo groups at positions 2, 8 and 13, methyl group at position 5, hydroxy groups at positions 7 and 12, and a (2R)-butan-2-yl group at position 1. It is a mixture of epimers at the hemiaminal carbon (position 3a). | 3.17 | 1 | 0 | | |
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety. | 2.07 | 1 | 0 | organophosphate oxoanion | cofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite |
jadomycin b
jadomycin B: structure given in first source; isolated from Streptomyces venezuelae. jadomycin B : A jadomycin that is jadomycin A in which the phenolic hydroxy group at position 12 has been converted to the corresponding 2,6-dideoxy-alpha-L-ribo-hexopyranoside, isolated from Streptomyces venezuelae. It exists as a diastereoisomeric mixture consisting of both 3aS and 3aR isomers. | 3.17 | 1 | 0 | glycoside;
jadomycin;
organic heteropentacyclic compound | antibacterial agent;
antineoplastic agent;
apoptosis inducer;
Aurora kinase inhibitor;
bacterial metabolite |
landomycinone
landomycinone: structure in first source | 7.02 | 1 | 0 | | |
landomycin d
landomycin D: structure in first source | 2.72 | 3 | 0 | anthraquinone | metabolite |
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group. | 3.17 | 1 | 0 | benzenes;
hydroxycoumarin;
methyl ketone | |
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. | 7.02 | 1 | 0 | | |
chrysomycin b
chrysomycin B: structure given in first source | 3.17 | 1 | 0 | | |
kinamycin a
kinamycin A: isolated from Streptomyces muragamaensis; RN in Chemline for Kinamycin B: 35303-13-0; RN for Kinamycin C: 35303-08-3; RN for Kinamycin D: 35303-14-1; RN given refers to parent cpd; structure | 3.17 | 1 | 0 | kinamycin | |
kinamycin f
kinamycin F: isolated from Streptomyces murayamaensis; structure given in first source | 3.17 | 1 | 0 | kinamycin | |
angucyclinone
angucyclinone: structure in first source | 3.17 | 1 | 0 | | |