| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
huperzine a
huperzine A: RN given refers to 5R-(5alpha,9beta,11E)-isomer; structure given in first source. huperzine A : A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease. | 2.31 | 1 | 0 | quinolone | |
lapachol
lapachol : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae. | 3.05 | 1 | 0 | | |
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae. | 3.05 | 1 | 0 | mitomycin | alkylating agent;
antineoplastic agent |
benzo(a)fluorene
benzo(a)fluorene: structure in first source | 2.01 | 1 | 0 | carbotetracyclic compound | |
chrysomycin a
chrysomycin A: Streptomyces arenae; differs only in sugar moiety from gilvocarcin V | 3.17 | 1 | 0 | glycoside | |
ay 25545
ravidomycin: isolated from mycelium of Streptomyces ravidus; structure given in first source. ravidomycin : A C-glycosylated naphthoisochromene derivative obtained from Streptomyces ravidus; exhibits antibiotic and anticancer properties. | 3.17 | 1 | 0 | acetate ester;
aromatic ether;
C-glycosyl compound;
naphthoisochromene;
olefinic compound;
phenols;
tertiary amine | antimicrobial agent;
antineoplastic agent;
bacterial metabolite |
kalafungin
kalafungin: nanaomycin D from Streptomyces rosa & is enantiomer of kalafungin; RN given refers to (3aR-(3aalpha,5alpha,11balpha))-isomer; see also nanaomycin C; structure of kalafungin in first source; structure of nanaomycin in second source | 3.05 | 1 | 0 | | |
glycosides
[no description available] | 3.17 | 1 | 0 | | |
sesquiterpenes
[no description available] | 2.31 | 1 | 0 | | |
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups. | 4.3 | 3 | 0 | | |
landomycin a
landomycin A: structure given in first source; isolated from Streptomyces sp. | 3.17 | 1 | 0 | oligosaccharide | metabolite |
gilvocarcin v
gilvocarcin V: from Actinomycete DO-38; structure given in first source | 3.17 | 1 | 0 | | |
jadomycin a
jadomycin A: the aglycone of jadomycin B; structure in first source. jadomycin A : A organic heteropentacyclic compound that is 1,2,8,13-tetrahydro-3aH-benzo[b][1,3]oxazolo[3,2-f]phenanthridine which carries oxo groups at positions 2, 8 and 13, methyl group at position 5, hydroxy groups at positions 7 and 12, and a (2R)-butan-2-yl group at position 1. It is a mixture of epimers at the hemiaminal carbon (position 3a). | 3.17 | 1 | 0 | | |
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety. | 2.03 | 1 | 0 | organophosphate oxoanion | cofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite |
jadomycin b
jadomycin B: structure given in first source; isolated from Streptomyces venezuelae. jadomycin B : A jadomycin that is jadomycin A in which the phenolic hydroxy group at position 12 has been converted to the corresponding 2,6-dideoxy-alpha-L-ribo-hexopyranoside, isolated from Streptomyces venezuelae. It exists as a diastereoisomeric mixture consisting of both 3aS and 3aR isomers. | 3.17 | 1 | 0 | glycoside;
jadomycin;
organic heteropentacyclic compound | antibacterial agent;
antineoplastic agent;
apoptosis inducer;
Aurora kinase inhibitor;
bacterial metabolite |
landomycin e
landomycin E: structure given in first source; isolated from Streptomyces sp. | 3.17 | 1 | 0 | oligosaccharide | |
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group. | 3.17 | 1 | 0 | benzenes;
hydroxycoumarin;
methyl ketone | |
chrysomycin b
chrysomycin B: structure given in first source | 3.17 | 1 | 0 | | |
kinamycin c
kinamycin C: an antineoplastic antibiotic that inhibits topoisomerase IIalpha; isolated from Streptomyces murayamaensis | 2.03 | 1 | 0 | kinamycin | |
kinamycin f
kinamycin F: isolated from Streptomyces murayamaensis; structure given in first source | 3.17 | 1 | 0 | kinamycin | |
angucyclinone
angucyclinone: structure in first source | 3.17 | 1 | 0 | | |