Page last updated: 2024-11-12

ilicic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ilicic acid: from Inula viscosa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
InulagenusA plant genus of the family ASTERACEAE. Members contain INULIN, alantol, helenin, alantic acid, and acrid resin.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID11876195
CHEMBL ID408129
CHEBI ID181639
MeSH IDM0429836

Synonyms (19)

Synonym
2-[(2r,4ar,8r,8ar)-8-hydroxy-4a,8-dimethyl-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid
CHEBI:181639
4586-68-9
ilicic acid
MEGXP0_000659
ACON1_002392
NCGC00169889-01
BRD-K44501162-001-01-2
CHEMBL408129
vachanic acid
AKOS032428137
1268477-79-7
ncgc00169889-02_c15h24o3_2-[(2r,4ar,8r,8ar)-8-hydroxy-4a,8-dimethyldecahydro-2-naphthalenyl]acrylic acid
NCGC00169889-02
FS-9897
2-((2r,4ar,8r,8ar)-8-hydroxy-4a,8-dimethyldecahydronaphthalen-2-yl)acrylic acid
(2r,4ar,8r,8ar)-decahydro-8-hydroxy-4a,8-dimethyl--methylene-2-naphthaleneacetic acid; vachanic acid
HY-N4015
CS-0024443

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
eudesmane sesquiterpenoidAny sesquiterpenoid having a eudesmane skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID379446Antiinflammatory activity against Swiss mouse assessed as inhibition of carrageenan-induced paw volume at 100 mg/kg, po administered 1 hr prior to carrageenan challenge measured after 3 hrs1999Journal of natural products, Apr, Volume: 62, Issue:4
A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
AID450984Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.
AID450979Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.
AID450982Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.
AID450980Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.
AID320961Inhibition of serotonin release in bovine platelets2008Journal of medicinal chemistry, Mar-13, Volume: 51, Issue:5
Neural networks as valuable tools to differentiate between sesquiterpene lactones' inhibitory activity on serotonin release and on NF-kappaB.
AID356298Cytotoxicity against human SK-MEL cells at 20 ug/mL after 72 hrs2003Journal of natural products, Aug, Volume: 66, Issue:8
Eudesmane derivatives and other sesquiterpenes from Laggera alata.
AID379444Antiinflammatory activity against Swiss mouse assessed as inhibition of arachidonic acid-induced edema at 0.5 mg/ear applied 30 mins before arachidonic acid challenge measured after 1 hr1999Journal of natural products, Apr, Volume: 62, Issue:4
A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
AID1776886Antiinflammatory activity in LPS-induced in C57 mouse BMDM cells assessed as reduction in IL-12 mRNA expression at 20 uM incubated for 12 hrs by qRT-PCR analysis2021Journal of natural products, 05-28, Volume: 84, Issue:5
Anti-inflammatory Eudesmane Sesquiterpenoids from
AID450983Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.
AID379449Antiinflammatory activity against Swiss mouse chronic dermatitis model assessed as inhibition of TPA-induced tissue myeloperoxidase activity at 0.5 mg/ear applied twice daily for 4 days measured after 6 hrs1999Journal of natural products, Apr, Volume: 62, Issue:4
A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
AID379447Antiinflammatory activity against Swiss mouse assessed as inhibition of carrageenan-induced paw volume at 100 mg/kg, po administered 1 hr prior to carrageenan challenge measured after 5 hrs1999Journal of natural products, Apr, Volume: 62, Issue:4
A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
AID379448Antiinflammatory activity against Swiss mouse chronic dermatitis model assessed as inhibition of TPA-induced edema at 0.5 mg/ear applied twice daily for 4 days measured after 6 hrs1999Journal of natural products, Apr, Volume: 62, Issue:4
A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
AID379443Antiinflammatory activity against Swiss mouse assessed as inhibition of TPA-induced edema at 0.5 mg/ear applied simultaneously with TPA measured after 4 hrs1999Journal of natural products, Apr, Volume: 62, Issue:4
A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
AID450981Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay2009Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.
AID379445Antiinflammatory activity against Swiss mouse assessed as inhibition of carrageenan-induced paw volume at 100 mg/kg, po administered 1 hr prior to carrageenan challenge measured after 1 hr1999Journal of natural products, Apr, Volume: 62, Issue:4
A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
AID1776887Antiinflammatory activity in LPS-induced in C57 mouse BMDM cells assessed as reduction in TNFalpha mRNA expression at 20 uM incubated for 12 hrs by qRT-PCR analysis2021Journal of natural products, 05-28, Volume: 84, Issue:5
Anti-inflammatory Eudesmane Sesquiterpenoids from
AID356299Cytotoxicity against human A549 cells at 20 ug/mL after 72 hrs2003Journal of natural products, Aug, Volume: 66, Issue:8
Eudesmane derivatives and other sesquiterpenes from Laggera alata.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's4 (36.36)29.6817
2010's3 (27.27)24.3611
2020's3 (27.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.15 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index5.00 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]