ilicic-acid and Neoplasms

ilicic-acid has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for ilicic-acid and Neoplasms

Article	Year
Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines. Bioorganic & medicinal chemistry, 2009, Sep-01, Volume: 17, Issue:17 A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.9-4.5 microM. Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G(2)/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule. Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; G2 Phase; Humans; Neoplasms; Quantitative Structure-Activity Relationship; Sesquiterpenes	2009

Article

Year

Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.

Bioorganic & medicinal chemistry, 2009, Sep-01, Volume: 17, Issue:17

A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.9-4.5 microM. Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G(2)/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule.

Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; G2 Phase; Humans; Neoplasms; Quantitative Structure-Activity Relationship; Sesquiterpenes

2009