| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
helenalin
helenalin: toxic principle of Helenium microcephalum (smallhead sneezeweed); structure. helenalin : A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer).. NF-kappaB inhibitor : An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA. | 2.04 | 1 | 0 | cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone | anti-inflammatory agent;
antineoplastic agent;
metabolite;
plant metabolite |
quassin
quassin: article discusses quassinoid principle; structure | 2.11 | 1 | 0 | triterpenoid | |
isoalantolactone
isoalantolactone: RN given refers to (3aR-(3aalpha,4aalpha,8abeta,9aalpha))-isomer; structure. isoalantolactone : A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium. | 2.04 | 1 | 0 | eudesmane sesquiterpenoid;
sesquiterpene lactone | antifungal agent;
apoptosis inducer;
plant metabolite |
parthenolide
[no description available] | 2.04 | 1 | 0 | germacranolide | |
amarogentin
amarogentin: secoiridoid glycoside. amarogentin : A secoiridoid glycoside that consists of (4aS,5R,6R)-5-ethenyl-6-hydroxy-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one having a 2-O-[(3,3',5-trihydroxybiphenyl-2-yl)carbonyl]-beta-D-glucopyranosyl group attached at position 6 via a glycosidic linkage. | 2.11 | 1 | 0 | monosaccharide derivative;
secoiridoid glycoside | EC 5.99.1.2 (DNA topoisomerase) inhibitor;
metabolite |
cynaropicrin
cynaropicrin: structure given in first source; RN given for ((3aR-(3aalpha,4alpha,6aalpha,8beta,9aalpha,9bbeta)))-isomer | 2.13 | 1 | 0 | sesquiterpene lactone | |
aguerin b
aguerin B: has antiproliferative activity; structure in first source | 2.13 | 1 | 0 | | |
santamarine
santamarine: sesquiterpene derivative of costunolide. santamarin : A sesquiterpene lactone of the eudesmanolide group. | 2.04 | 1 | 0 | sesquiterpene lactone | |
santonin
Santonin: Anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region. (From Merck, 11th ed.) | 2.04 | 1 | 0 | botanical anti-fungal agent;
santonin | plant metabolite |
tenulin
tenulin: toxic constituent of Helenium amarum (bitter sneezeweed); structure | 2.04 | 1 | 0 | sesquiterpene lactone | |
coronopilin
coronopilin: isolated from Ambrosia arborescens | 2.04 | 1 | 0 | sesquiterpene lactone | |
absynthin
absynthin: isolated from diferent species of the genus Artemisia; antiparasitic cpd. absinthin : A dimeric sesquiterpene lactone that is produced by the plant Artemisia absinthium (Wormwood). The bitter tasting constituent of Absinthe. | 2.11 | 1 | 0 | organic heteroheptacyclic compound;
sesquiterpene lactone;
triterpenoid | anti-inflammatory agent;
plant metabolite |
Canin
[no description available] | 2.04 | 1 | 0 | sesquiterpene lactone | |
parthenin
parthenin: sesqiterpene lactone from Parthenium hysterophorus; structure; RN given refers to 3aS-(3aalpha,6beta,6abeta,9abeta,9balpha)-isomer | 2.04 | 1 | 0 | sesquiterpene lactone | |
iridoids
Iridoids: A type of MONOTERPENES, derived from geraniol. They have the general form of cyclopentanopyran, but in some cases, one of the rings is broken as in the case of secoiridoid. They are different from the similarly named iridals (TRITERPENES). | 2.11 | 1 | 0 | | |
reynosin
reynosin: sesquiterpene derivative of costunolide. reynosin : A sesquiterpene lactone of the eudesmanolide group, found particularly in Magnolia grandiflora and Laurus nobilis. | 2.04 | 1 | 0 | organic heterotricyclic compound;
sesquiterpene lactone | metabolite |
sesquiterpenes
[no description available] | 2.7 | 3 | 0 | | |
phenylthiourea
Phenylthiourea: Phenylthiourea is a THIOUREA derivative containing a phenyl ring. Depending on their genetic makeup, humans can find it either bitter-tasting or tasteless.. N-phenylthiourea : A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing. | 2.11 | 1 | 0 | thioureas | EC 1.14.18.1 (tyrosinase) inhibitor |
quinine
[no description available] | 2.11 | 1 | 0 | cinchona alkaloid | antimalarial;
muscle relaxant;
non-narcotic analgesic |
angiotensin amide
psilostachyin A: has antineoplastic, anti-inflammatory, leishmanicidal, and molluscicidal activities; isolated from Ambrosia psilostachya; structure in first source | 2.04 | 1 | 0 | | |
ilicic acid
ilicic acid: from Inula viscosa; structure in first source | 2.04 | 1 | 0 | eudesmane sesquiterpenoid | |
eudesmanolide
eudesmanolide: structure in first source | 2.04 | 1 | 0 | sesquiterpene lactone | |