Page last updated: 2024-12-08

Canin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	442175
CHEBI ID	3356

Synonyms (11)

Synonym
canin
C09354
24959-84-0
chebi:3356 ,
4h-bisoxireno(1,8a:2,3)azuleno(4,5-b)furan-2(3h)-one, octahydro-6-hydroxy-6,8a-dimethyl-3-methylene-, (3as-(3aalpha,6alpha,6as*,7abeta,7bbeta,8abeta,8balpha,8cbeta))-
octahydro-6-hydroxy-6,8a-dimethyl-3-methylene-4h-bisoxireno(1,8a:2,3)azuleno(4,5-b)furan-2(3h)-one (3as-(3aalpha,6alpha,6as*,7abeta,7bbeta,8abeta,8balpha,8cbeta))-
canin (chrysartemin a)
Q27106041
6-hydroxy-6,8a-dimethyl-3-methylideneoctahydro-4h-bisoxireno[2,3:1,8a]azuleno[4,5-b]furan-2(3h)-one
DTXSID70947832
(1r,2r,5s,9s,10s,11s,13r,14s)-2-hydroxy-2,11-dimethyl-6-methylidene-8,12,15-trioxapentacyclo[8.5.0.01,14.05,9.011,13]pentadecan-7-one

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
sesquiterpene lactone	Any member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID1594833	Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis	2019	Journal of natural products, 06-28, Volume: 82, Issue:6	Sesquiterpene Lactones from Artemisia argyi: Absolute Configuration and Immunosuppressant Activity.
AID1875649	Inhibition of PI3K/AKT signalling pathway in human MM121224 cells stably expressing H2B-mTurquoise, ERK-KTR-mScarlet and FoxO3a-KTR-mNeonGreen fluorophore assessed as AKT activity by high-content screening microscopic analysis
AID336310	Antimigraine activity in bovine citreated platelet assessed as inhibition of [14C]serotonin release after 6 mins by scintillation counting	1992	Journal of natural products, Aug, Volume: 55, Issue:8	A bioassay for inhibition of serotonin release from bovine platelets.
AID1875650	Inhibition of MAPK/ERK signalling pathway in human MM121224 cells stably expressing H2B-mTurquoise, ERK-KTR-mScarlet and FoxO3a-KTR-mNeonGreen fluorophore assessed as effect on EKR-KTR activity by high-content screening microscopic analysis
AID320961	Inhibition of serotonin release in bovine platelets	2008	Journal of medicinal chemistry, Mar-13, Volume: 51, Issue:5	Neural networks as valuable tools to differentiate between sesquiterpene lactones' inhibitory activity on serotonin release and on NF-kappaB.
AID355723	Cytotoxicity against human HCT116 cells by MTT assay	2003	Journal of natural products, Apr, Volume: 66, Issue:4	Sesquiterpenoids from Artemisia gilvescens and an anti-MRSA compound.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	1 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 138.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	138.87 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.55 (4.65)
Search Engine Demand Index	316.77 (26.88)
Search Engine Supply Index	2.52 (0.95)

This Compound (138.87)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
helenalin helenalin: toxic principle of Helenium microcephalum (smallhead sneezeweed); structure. helenalin : A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer).. NF-kappaB inhibitor : An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.	2.04	1	cyclic ketone; gamma-lactone; organic heterotricyclic compound; secondary alcohol; sesquiterpene lactone	anti-inflammatory agent; antineoplastic agent; metabolite; plant metabolite
propranolol hydrochloride Inderex: combination of above cpds; used in treatment of hypertension	1.98	1	hydrochloride
verapamil hydrochloride verapamil hydrochloride : A racemate comprising equimolar amounts of dexverapamil hydrochloride and (S)-verapamil hydrochloride.	1.98	1
isoalantolactone isoalantolactone: RN given refers to (3aR-(3aalpha,4aalpha,8abeta,9aalpha))-isomer; structure. isoalantolactone : A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium.	2.41	2	eudesmane sesquiterpenoid; sesquiterpene lactone	antifungal agent; apoptosis inducer; plant metabolite
parthenolide [no description available]	2.41	2	germacranolide
santamarine santamarine: sesquiterpene derivative of costunolide. santamarin : A sesquiterpene lactone of the eudesmanolide group.	2.72	3	sesquiterpene lactone
santonin Santonin: Anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region. (From Merck, 11th ed.)	2.41	2	botanical anti-fungal agent; santonin	plant metabolite
tenulin tenulin: toxic constituent of Helenium amarum (bitter sneezeweed); structure	2.04	1	sesquiterpene lactone
coronopilin coronopilin: isolated from Ambrosia arborescens	2.04	1	sesquiterpene lactone
grosheimin grosheimin: from the aerial parts of V. decurens; structure	2.04	1	sesquiterpene lactone
parthenin parthenin: sesqiterpene lactone from Parthenium hysterophorus; structure; RN given refers to 3aS-(3aalpha,6beta,6abeta,9abeta,9balpha)-isomer	2.41	2	sesquiterpene lactone
reynosin reynosin: sesquiterpene derivative of costunolide. reynosin : A sesquiterpene lactone of the eudesmanolide group, found particularly in Magnolia grandiflora and Laurus nobilis.	2.41	2	organic heterotricyclic compound; sesquiterpene lactone	metabolite
eupatilin eupatilin: isolated from Artemisia argyi. eupatilin : A trimethoxyflavone that is flavone substituted by hydroxy groups at C-5 and C-7 and methoxy groups at C-6, C-3' and C-4' respectively. Isolated from Citrus reticulata and Salvia tomentosa, it exhibits anti-inflammatory, anti-ulcer and antineoplastic activities.	2.21	1	dihydroxyflavone; trimethoxyflavone	anti-inflammatory agent; anti-ulcer drug; antineoplastic agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; metabolite
cyclosporine ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF	2.21	1	homodetic cyclic peptide	anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite
angiotensin amide psilostachyin A: has antineoplastic, anti-inflammatory, leishmanicidal, and molluscicidal activities; isolated from Ambrosia psilostachya; structure in first source	2.04	1
jaceosidin jaceosidin : A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties.	2.21	1	dimethoxyflavone; trihydroxyflavone	anti-allergic agent; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; metabolite
ilicic acid ilicic acid: from Inula viscosa; structure in first source	2.04	1	eudesmane sesquiterpenoid
eudesmanolide eudesmanolide: structure in first source	2.04	1	sesquiterpene lactone

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