| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
helenalin
helenalin: toxic principle of Helenium microcephalum (smallhead sneezeweed); structure. helenalin : A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer).. NF-kappaB inhibitor : An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA. | 2.04 | 1 | 0 | cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone | anti-inflammatory agent;
antineoplastic agent;
metabolite;
plant metabolite |
propranolol hydrochloride
Inderex: combination of above cpds; used in treatment of hypertension | 1.98 | 1 | 0 | hydrochloride | |
verapamil hydrochloride
verapamil hydrochloride : A racemate comprising equimolar amounts of dexverapamil hydrochloride and (S)-verapamil hydrochloride. | 1.98 | 1 | 0 | | |
isoalantolactone
isoalantolactone: RN given refers to (3aR-(3aalpha,4aalpha,8abeta,9aalpha))-isomer; structure. isoalantolactone : A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium. | 2.41 | 2 | 0 | eudesmane sesquiterpenoid;
sesquiterpene lactone | antifungal agent;
apoptosis inducer;
plant metabolite |
parthenolide
[no description available] | 2.41 | 2 | 0 | germacranolide | |
santamarine
santamarine: sesquiterpene derivative of costunolide. santamarin : A sesquiterpene lactone of the eudesmanolide group. | 2.72 | 3 | 0 | sesquiterpene lactone | |
santonin
Santonin: Anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region. (From Merck, 11th ed.) | 2.41 | 2 | 0 | botanical anti-fungal agent;
santonin | plant metabolite |
tenulin
tenulin: toxic constituent of Helenium amarum (bitter sneezeweed); structure | 2.04 | 1 | 0 | sesquiterpene lactone | |
coronopilin
coronopilin: isolated from Ambrosia arborescens | 2.04 | 1 | 0 | sesquiterpene lactone | |
grosheimin
grosheimin: from the aerial parts of V. decurens; structure | 2.04 | 1 | 0 | sesquiterpene lactone | |
parthenin
parthenin: sesqiterpene lactone from Parthenium hysterophorus; structure; RN given refers to 3aS-(3aalpha,6beta,6abeta,9abeta,9balpha)-isomer | 2.41 | 2 | 0 | sesquiterpene lactone | |
reynosin
reynosin: sesquiterpene derivative of costunolide. reynosin : A sesquiterpene lactone of the eudesmanolide group, found particularly in Magnolia grandiflora and Laurus nobilis. | 2.41 | 2 | 0 | organic heterotricyclic compound;
sesquiterpene lactone | metabolite |
eupatilin
eupatilin: isolated from Artemisia argyi. eupatilin : A trimethoxyflavone that is flavone substituted by hydroxy groups at C-5 and C-7 and methoxy groups at C-6, C-3' and C-4' respectively. Isolated from Citrus reticulata and Salvia tomentosa, it exhibits anti-inflammatory, anti-ulcer and antineoplastic activities. | 2.21 | 1 | 0 | dihydroxyflavone;
trimethoxyflavone | anti-inflammatory agent;
anti-ulcer drug;
antineoplastic agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
metabolite |
cyclosporine
ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF | 2.21 | 1 | 0 | homodetic cyclic peptide | anti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite |
angiotensin amide
psilostachyin A: has antineoplastic, anti-inflammatory, leishmanicidal, and molluscicidal activities; isolated from Ambrosia psilostachya; structure in first source | 2.04 | 1 | 0 | | |
jaceosidin
jaceosidin : A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apoptosis inducing activties. | 2.21 | 1 | 0 | dimethoxyflavone;
trihydroxyflavone | anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
metabolite |
ilicic acid
ilicic acid: from Inula viscosa; structure in first source | 2.04 | 1 | 0 | eudesmane sesquiterpenoid | |
eudesmanolide
eudesmanolide: structure in first source | 2.04 | 1 | 0 | sesquiterpene lactone | |