dodicin profile

Dodicin is a naturally occurring antimicrobial peptide with a broad spectrum of activity against bacteria, fungi, and viruses. It is produced by the skin glands of the European toad, Bufo bufo. Dodicin's antimicrobial activity is attributed to its ability to disrupt the cell membrane of microorganisms. It has also been shown to have immunomodulatory effects, stimulating the production of cytokines and enhancing the activity of immune cells. Dodicin is currently being studied for its potential as a therapeutic agent for the treatment of infections and inflammatory diseases. Its high potency, broad spectrum of activity, and low toxicity make it a promising candidate for the development of novel antibiotics and immunomodulatory drugs.'

dodicin: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	23280
CHEMBL ID	2105028
SCHEMBL ID	166202
MeSH ID	M0045204

Synonym
dodicin
2-[2-[2-(dodecylamino)ethylamino]ethylamino]acetic acid
6843-97-6
CHEMBL2105028
unii-72t37al5jv
epa pesticide chemical code 413300
dodicin [ban]
8-dodecyl-2,5,8-triazaoctane-1-carboxylic acid
glycine, n-(2-((2-(dodecylamino)ethyl)amino)ethyl)-
einecs 229-930-7
caswell no. 413a
dodecylbis(aminoethyl)glycine
n-(2-((-(dodecylamino)ethyl)amino)ethyl)glycine
3,6,9-triazahenicosanoic acid
lauryl diethylenediaminoglycine
72t37al5jv ,
n-(2-((2-(dodecylamino)ethyl)amino)ethyl)glycine
dodicin [iso]
lauryl diethylenediaminoglycine [inci]
dodicin [mart.]
dodicin [who-dd]
n-(2-(2-dodecylaminoethylamino)ethyl)glycine
n-lauryldiethylenetriaminoactetic acid
SCHEMBL166202
DTXSID9058159
9-lauryl-3,6,9-triazanonanoic acid
NCGC00274269-01
n-[2-(2-dodecylaminoethylamino)ethyl]glycine or,3,6,9-triazaheneicosanoic acid
Q27266096
HY-153722
CS-0835553

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	12.5893	0.0096	10.5250	35.4813	AID1479145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
virion membrane	Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus
[Information is prepared from geneontology information from the June-17-2024 release]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (55.56)	18.7374
1990's	5 (27.78)	18.2507
2000's	3 (16.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	6 (33.33%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (66.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycine [no description available]	4.22	18	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	1.96	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
2-propanol 2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.. propan-2-ol : A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.	2.01	1	secondary alcohol; secondary fatty alcohol	protic solvent
edetic acid Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.	1.96	1	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector
methicillin Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.	1.98	1	penicillin allergen; penicillin	antibacterial drug
tetraethoxysilane [no description available]	2.03	1
bisphenol a-glycidyl methacrylate Bisphenol A-Glycidyl Methacrylate: The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials.	1.96	1	diarylmethane
hypochlorous acid Hypochlorous Acid: An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.. hypochlorous acid : A chlorine oxoacid with formula HOCl; a weak, unstable acid, it is the active form of chlorine in water.	1.96	1	chlorine oxoacid; reactive oxygen species	EC 2.5.1.18 (glutathione transferase) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; human metabolite
bisphenol a epoxy resin diacrylate ester bisphenol A epoxy resin diacrylate ester: prepolymer in ultraviolet curing inks; structure given in first source	1.96	1
povidone-iodine Povidone-Iodine: An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.	2.39	2
potassium permanganate Potassium Permanganate: Permanganic acid (HMnO4), potassium salt. A highly oxidative, water-soluble compound with purple crystals, and a sweet taste. (From McGraw-Hill Dictionary of Scientific and Technical Information, 4th ed)	1.96	1
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	1.96	1	organic sodium salt	detergent; protein denaturant
chlorhexidine Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.	2.39	2	biguanides; monochlorobenzenes	antibacterial agent; antiinfective agent
sodium hypochlorite Sodium Hypochlorite: It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant & Hackh's Chemical Dictionary, 5th ed). sodium hypochlorite : An inorganic sodium salt in which hypochlorite is the counterion. It is used as a bleaching and disinfecting agent and is commonly found in household bleach.	2.38	2	inorganic sodium salt	bleaching agent; disinfectant

Condition	Relationship Strength	Studies
Allergic Contact Dermatitis [description not available]	2.01	1
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	2.01	1
Contact Dermatitis [description not available]	2.88	4
Dermatitis, Occupational A recurrent contact dermatitis caused by substances found in the work place.	3.22	6
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	2.88	4
CJD (Creutzfeldt-Jakob Disease) [description not available]	1.96	1
Rida [description not available]	1.96	1
Creutzfeldt-Jakob Syndrome A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))	1.96	1
Eczema, Atopic [description not available]	1.95	1
Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	1.95	1
Health Care Associated Infection [description not available]	1.99	1
Opportunistic Infections An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.	1.99	1
Bacterial Infections, Gram-Negative [description not available]	1.99	1
Infections, Serratia [description not available]	1.99	1
Cross Infection Any infection which a patient contracts in a health-care institution.	1.99	1
Gram-Negative Bacterial Infections Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.	1.99	1
Facial Dermatoses Skin diseases involving the FACE.	1.97	1
Hand Dermatosis [description not available]	2.66	3
Hand Dermatoses Skin diseases involving the HANDS.	2.66	3

dodicin

Description

Cross-References

Synonyms (31)

Protein Targets (1)

Potency Measurements

Ceullar Components (1)

Research

Studies (18)

Market Indicators

Research Demand Index: 16.40

Study Types