Page last updated: 2024-09-29

ace-011

Description

ACE-011: a dimeric fusion protein consisting of the extracellular domain of the human ActRIIA linked to the Fc portion of human IgG1 and may be an effective therapy in a variety of diseases involving bone loss [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID2877953
SCHEMBL ID2204761
MeSH IDM0537365

Synonyms (24)

Synonym
CBMICRO_030367
ace-011
OPREA1_342150
DIVK1C_005743
CDS1_004703 ,
BIM-0030123.P001
n-(2-ethoxy-4-nitrophenyl)acetamide
AKOS001044796
116496-76-5
4-acetamido-3-ethoxynitrobenzene
acetamide, n-(2-ethoxy-4-nitrophenyl)-
PS-6223
AB07920
acetamide,n-(2-ethoxy-4-nitrophenyl)-
n-(2-ethoxy-4-nitrophenyl) acetamide
XZWVZJDHIDYKPB-UHFFFAOYSA-N
mfcd00994990
SCHEMBL2204761
DTXSID60387001
SR-01000223946-1
sr-01000223946
FT-0715219
4-(4-ethoxycarbonylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester
Z56871699

Research

Studies (46)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (2.17)29.6817
2010's29 (63.04)24.3611
2020's16 (34.78)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials10 (21.28%)5.53%
Reviews10 (21.28%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (57.45%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (1)

ArticleYear
Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women.
Journal of clinical pharmacology, Volume: 53, Issue: 11
2013
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (1)

ArticleYear
Multiple-dose, safety, pharmacokinetic, and pharmacodynamic study of sotatercept (ActRIIA-IgG1), a novel erythropoietic agent, in healthy postmenopausal women.
Journal of clinical pharmacology, Volume: 53, Issue: 11
2013
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (2)

ArticleYear
From bench to bedside: The promise of sotatercept in hematologic disorders.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Volume: 165
2023
Single-dose, randomized, double-blind, placebo-controlled study of ACE-011 (ActRIIA-IgG1) in postmenopausal women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Volume: 24, Issue: 4
2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]