5-hydroxy-2-(2-phenylethyl)chromone profile

5-hydroxy-2-(2-phenylethyl)chromone: neuroprotective compound from rhizomes of Imperata cylindrica; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Imperata	genus	[no description available]	Poaceae	A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.[MeSH]

ID Source	ID
PubMed CID	11536299
CHEMBL ID	479683
SCHEMBL ID	16972760
MeSH ID	M0496200

Synonym
smr001397498
MLS002473407
CHEMBL479683 ,
877673-99-9
bdbm50449333
5-hydroxy-2-(2-phenylethyl)chromone
5-hydroxy-2-(2-phenylethyl)chromen-4-one
DTXSID40468221
SCHEMBL16972760
5-hydroxy-2-phenethyl-4h-chromen-4-one
5-hydroxy-2-(2-phenylethyl)-4h-chromen-4-one

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	89.1251	0.6310	35.7641	100.0000	AID504339
Nrf2	Homo sapiens (human)	Potency	35.4813	0.0920	8.2222	23.1093	AID624171
chromobox protein homolog 1	Homo sapiens (human)	Potency	79.4328	0.0060	26.1688	89.1251	AID540317
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	8.9125	1.7783	16.2081	35.4813	AID652104
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
5-hydroxytryptamine receptor 1E	Homo sapiens (human)	Ki	10.0000	0.0930	4.7701	10.0000	AID1076854
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	IC50 (µMol)	8.9125	0.0001	1.1873	8.9125	AID1076871
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	Ki	2.4547	0.0003	0.7693	10.0000	AID1076853
5-hydroxytryptamine receptor 3A	Homo sapiens (human)	Ki	2.5119	0.0000	0.7411	9.9000	AID1076852
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
G protein-coupled receptor signaling pathway	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
adenylate cyclase-inhibiting serotonin receptor signaling pathway	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
chemical synaptic transmission	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
neural crest cell migration	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
positive regulation of cytokine production	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
positive regulation of endothelial cell proliferation	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
G protein-coupled receptor internalization	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
heart morphogenesis	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
cardiac muscle hypertrophy	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
intracellular calcium ion homeostasis	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
G protein-coupled receptor signaling pathway	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
activation of phospholipase C activity	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
protein kinase C-activating G protein-coupled receptor signaling pathway	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
phospholipase C-activating serotonin receptor signaling pathway	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
positive regulation of cell population proliferation	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
response to xenobiotic stimulus	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
positive regulation of phosphatidylinositol biosynthetic process	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
neural crest cell differentiation	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
intestine smooth muscle contraction	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
phosphorylation	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
calcium-mediated signaling	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
cGMP-mediated signaling	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
vasoconstriction	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
negative regulation of apoptotic process	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
positive regulation of MAP kinase activity	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
embryonic morphogenesis	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
regulation of behavior	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
positive regulation of nitric-oxide synthase activity	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
release of sequestered calcium ion into cytosol	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
positive regulation of cell division	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
ERK1 and ERK2 cascade	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
protein kinase C signaling	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
cellular response to temperature stimulus	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
G protein-coupled serotonin receptor signaling pathway	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
serotonin receptor signaling pathway	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
chemical synaptic transmission	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
serotonin receptor signaling pathway	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
monoatomic ion transmembrane transport	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
excitatory postsynaptic potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
inorganic cation transmembrane transport	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
regulation of presynaptic membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
chemical synaptic transmission	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
regulation of membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
negative regulation of protein phosphorylation	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA processing	TAR DNA-binding protein 43	Homo sapiens (human)
RNA splicing	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of protein stability	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of insulin secretion	TAR DNA-binding protein 43	Homo sapiens (human)
response to endoplasmic reticulum stress	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of protein import into nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of circadian rhythm	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of apoptotic process	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation by host of viral transcription	TAR DNA-binding protein 43	Homo sapiens (human)
rhythmic process	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of cell cycle	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA destabilization	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA stabilization	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear inner membrane organization	TAR DNA-binding protein 43	Homo sapiens (human)
amyloid fibril formation	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
G protein-coupled receptor activity	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
G protein-coupled serotonin receptor activity	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
protein binding	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
serotonin binding	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
neurotransmitter receptor activity	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
Gq/11-coupled serotonin receptor activity	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
G-protein alpha-subunit binding	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
G protein-coupled serotonin receptor activity	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
GTPase activator activity	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
protein binding	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
serotonin binding	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
neurotransmitter receptor activity	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
protein binding	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
serotonin-gated monoatomic cation channel activity	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
identical protein binding	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
serotonin binding	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
excitatory extracellular ligand-gated monoatomic ion channel activity	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
double-stranded DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
RNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA 3'-UTR binding	TAR DNA-binding protein 43	Homo sapiens (human)
protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
lipid binding	TAR DNA-binding protein 43	Homo sapiens (human)
identical protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
pre-mRNA intronic binding	TAR DNA-binding protein 43	Homo sapiens (human)
molecular condensate scaffold activity	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
synapse	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
dendrite	5-hydroxytryptamine receptor 1E	Homo sapiens (human)
nucleoplasm	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
cytoplasm	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
synapse	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
G protein-coupled serotonin receptor complex	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
dendrite	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 2B	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
cleavage furrow	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
postsynaptic membrane	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
serotonin-activated cation-selective channel complex	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
synapse	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
plasma membrane	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
transmembrane transporter complex	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
neuron projection	5-hydroxytryptamine receptor 3A	Homo sapiens (human)
intracellular non-membrane-bounded organelle	TAR DNA-binding protein 43	Homo sapiens (human)
nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
perichromatin fibrils	TAR DNA-binding protein 43	Homo sapiens (human)
mitochondrion	TAR DNA-binding protein 43	Homo sapiens (human)
cytoplasmic stress granule	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear speck	TAR DNA-binding protein 43	Homo sapiens (human)
interchromatin granule	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
chromatin	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (57)

Assay ID	Title	Year	Journal	Article
AID1076858	Inhibition of muscarinic M2 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076877	Inhibition of 5-HT2C receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076857	Inhibition of NMDA receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076873	Inhibition of SERT (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076852	Displacement of [3H]GR65630 from 5-HT3 receptor (unknown origin)	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076869	Inhibition of histamine H1 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1675712	Antagonist activity at 5HT2A receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2020	Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21	Structure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT
AID1076866	Inhibition of alpha1A adrenergic receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076882	Inhibition of 5-HT1B receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076879	Inhibition of 5-HT2A receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076862	Inhibition of alpha2C adrenergic receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076881	Inhibition of 5-HT1D receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076872	Inhibition of dopamine D1 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1537167	Induction of adipogenesis in human bone marrow-derived mesenchymal stem cells assessed as increase in adiponectin production at 30 uM measured on day 5 in presence of IDX by ELISA	2019	Journal of natural products, 02-22, Volume: 82, Issue:2	Adiponectin-Secretion-Promoting Phenylethylchromones from the Agarwood of Aquilaria malaccensis.
AID1076861	Inhibition of beta-2 adrenergic receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076855	Inhibition of PBR (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076875	Inhibition of 5-HT6 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1235920	Displacement of [3H]mesulergine from human 5HT2C receptor expressed in Flp-IN HEK cell membranes at 10 uM	2015	Journal of natural products, Aug-28, Volume: 78, Issue:8	Synthesis and Characterization of 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC) and Its Analogues as Non-nitrogenous 5-HT2B Ligands.
AID1076867	Inhibition of sigma-2 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1235924	Antagonist activity against human 5HT2B receptor expressed in Flp-IN HEK cells assessed as inhibition of 5-HT-induced response at 10 uM by calcium mobilization assay	2015	Journal of natural products, Aug-28, Volume: 78, Issue:8	Synthesis and Characterization of 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC) and Its Analogues as Non-nitrogenous 5-HT2B Ligands.
AID1076850	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization at 10 uM relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076876	Inhibition of 5-HT3 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076880	Inhibition of 5-HT1E receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076854	Displacement of [3H]5-HT from 5-HT1E receptor (unknown origin)	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076868	Inhibition of histamine H3 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076860	Inhibition of benzodiazepine receptor in rat brain at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076865	Inhibition of alpha1B adrenergic receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1675711	Antagonist activity at 5HT2C receptor (unknown origin) 10 uM by radioligand binding assay relative to control	2020	Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21	Structure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT
AID1675713	Antagonist activity at 5HT2B receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2020	Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21	Structure activity relationship exploration of 5-hydroxy-2-(3-phenylpropyl)chromones as a unique 5-HT
AID1076871	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1235919	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes at 10 uM	2015	Journal of natural products, Aug-28, Volume: 78, Issue:8	Synthesis and Characterization of 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC) and Its Analogues as Non-nitrogenous 5-HT2B Ligands.
AID380081	Neuroprotective activity against glutamate-induced neurotoxicity in Sprague-Dawley rat cortical cells at 10 uM after 24 hrs by MTT assay relative to control	2006	Journal of natural products, Feb, Volume: 69, Issue:2	Neuroprotective 2-(2-phenylethyl)chromones of Imperata cylindrica.
AID1076864	Inhibition of alpha1D adrenergic receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076859	Inhibition of NET (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1235918	Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEKT cells membranes at 10 uM	2015	Journal of natural products, Aug-28, Volume: 78, Issue:8	Synthesis and Characterization of 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC) and Its Analogues as Non-nitrogenous 5-HT2B Ligands.
AID1076874	Inhibition of 5-HT7 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076883	Inhibition of 5-HT1A receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076863	Inhibition of alpha2A adrenergic receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076853	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076856	Inhibition of muscarinic M5 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076851	Agonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as stimulation of calcium mobilization at 10 uM relative to 5-HT	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076878	Inhibition of 5-HT2B receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID1076870	Inhibition of dopamine D5 receptor (unknown origin) at 10 uM by radioligand binding assay relative to control	2014	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 24, Issue:6	5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (20.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	3 (30.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glyburide Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide. glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.	2.21	1	monochlorobenzenes; N-sulfonylurea	anti-arrhythmia drug; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor; hypoglycemic agent
pioglitazone Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.. pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.	2.21	1	aromatic ether; pyridines; thiazolidinediones	antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2.03	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
2-(2-phenylethyl)chromone 2-(2-phenylethyl)chromone: from Aquilaria sinensis; structure given in first source. 2-(2-phenylethyl)chromone : A member of the class of chromones that is chromone which is substituted by a 2-phenylethyl group at position 2. It is found in agarwood, a fragrant resinous heartwood obtained from certain trees in the genus Aquilaria.	7.78	3	benzenes; chromones	plant metabolite
mdl 100907 Serotonin 5-HT2 Receptor Antagonists: Drugs that bind to but do not activate SEROTONIN 5-HT2 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT2 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more specific 5-HT2 receptor subtypes.	2.1	1
dizocilpine maleate Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.. dizocilpine maleate : A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.	2.03	1	maleate salt; tetracyclic antidepressant	anaesthetic; anticonvulsant; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.05	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.05	1	0

5-hydroxy-2-(2-phenylethyl)chromone

Description

Cross-References

Synonyms (11)

Protein Targets (7)

Potency Measurements

Inhibition Measurements

Biological Processes (62)

Molecular Functions (21)

Ceullar Components (19)

Bioassays (57)

Research

Studies (10)

Market Indicators

Research Demand Index: 12.17

Study Types

5-hydroxy-2-(2-phenylethyl)chromone

Description

Related Flora

Cross-References

Synonyms (11)

Protein Targets (7)

Potency Measurements

Inhibition Measurements

Biological Processes (62)

Molecular Functions (21)

Ceullar Components (19)

Bioassays (57)

Research

Studies (10)

Market Indicators

Research Demand Index: 12.17

Study Types

Related Drugs (6)

Related Conditions (2)