Compounds > 5'-thioadenosine

Page last updated: 2024-12-07

5'-thioadenosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

5'-thioadenosine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	128924
CHEMBL ID	1230723
SCHEMBL ID	2924722
MeSH ID	M0175195

Synonyms (16)

Synonym
a4d ,
CHEMBL1230723
5'-thioadenosine
67805-97-4
(2r,3r,4s,5s)-2-(6-aminopurin-9-yl)-5-(sulfanylmethyl)oxolane-3,4-diol
5'-deoxy-5'-thiodenosine scaffold, 6
bdbm84862
adenosine, 5'-thio-
SCHEMBL2924722
3IOB
9-(5-thiopentofuranosyl)-9h-purin-6-amine
DTXSID40987144
Q27457110
A900883
(2r,3r,4s,5s)-2-(6-amino-9h-purin-9-yl)-5-(mercaptomethyl)tetrahydrofuran-3,4-diol
(2r,3r,4s,5s)-2-(6-amino-9h-purin-9-yl)-5-(sulfanylmethyl)oxolane-3,4-diol

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Pantothenate synthetase	Mycobacterium tuberculosis	Kd	380.0000	380.0000	380.0000	380.0000	AID977611
Chain A, Pantothenate synthetase	Mycobacterium tuberculosis	Kd	380.0000	380.0000	380.0000	380.0000	AID977611
Chain A, Pantothenate synthetase	Mycobacterium tuberculosis	Kd	380.0000	380.0000	380.0000	380.0000	AID977611
Chain A, Pantothenate synthetase	Mycobacterium tuberculosis	Kd	380.0000	380.0000	380.0000	380.0000	AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID704836	Competitive inhibition of Mycobacterium tuberculosis Pantothenate synthetase by ITC method	2011	Journal of medicinal chemistry, Feb-24, Volume: 54, Issue:4	ATP-binding site of bacterial enzymes as a target for antibacterial drug design.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	2009	Chembiochem : a European journal of chemical biology, Nov-23, Volume: 10, Issue:17	A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.
AID1799634	Binding Assay from Article 10.1002/cbic.200900537: \\A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.\\	2009	Chembiochem : a European journal of chemical biology, Nov-23, Volume: 10, Issue:17	A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (14.29)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (28.57)	29.6817
2010's	4 (57.14)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (14.29%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
niacinamide nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.	2.08	1	0	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor
n-(2-aminoethyl)-5-isoquinolinesulfonamide [no description available]	3.16	1	0
ha 1004 N-(2-guanidinoethyl)-5-isoquinolinesulfonamide: structure given in first source	3.16	1	0	isoquinolines
uridine [no description available]	2.08	1	0	uridines	drug metabolite; fundamental metabolite; human metabolite
furaldehyde Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.	2.08	1	0	aldehyde; furans	Maillard reaction product; metabolite
5-methoxyindole 5-methoxyindole: structure in first source	3.16	1	0	indoles
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	3.28	6	0	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
cki 7 N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide: casein kinase I inhibitor; structure given in first source. N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide : A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.	3.16	1	0	isoquinolines; organochlorine compound; primary amino compound; sulfonamide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
5-hydroxymethylfurfural 5-hydroxymethylfurfural: has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo. 5-hydroxymethylfurfural : A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.	2.08	1	0	arenecarbaldehyde; furans; primary alcohol	indicator; Maillard reaction product
pyrophosphate Diphosphates: Inorganic salts of phosphoric acid that contain two phosphate groups.	7.15	1	0	diphosphate ion
monorden monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II	3.16	1	0	cyclic ketone; enone; epoxide; macrolide antibiotic; monochlorobenzenes; phenols	antifungal agent; metabolite; tyrosine kinase inhibitor
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	2.01	1	0	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
s-adenosylmethionine (R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.	1.97	1	0	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
novobiocin Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189). novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus.	3.16	1	0	carbamate ester; ether; hexoside; hydroxycoumarin; monocarboxylic acid amide; monosaccharide derivative; phenols	antibacterial agent; antimicrobial agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Escherichia coli metabolite; hepatoprotective agent
clorobiocin clorobiocin: chlorine-containing antibiotic related to novobiocin	3.16	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Bacterial Disease [description not available]	0	2.98	1	0
Bacterial Infections Infections by bacteria, general or unspecified.	0	2.98	1	0
Mental Retardation, X-Linked A class of genetic disorders resulting in INTELLECTUAL DISABILITY that is associated either with mutations of GENES located on the X CHROMOSOME or aberrations in the structure of the X chromosome (SEX CHROMOSOME ABERRATIONS).	0	2.05	1	0