Compounds > 4-nitropyridine
Page last updated: 2024-11-06

4-nitropyridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

4-Nitropyridine is a heterocyclic compound with a nitro group at the 4-position. It is a pale yellow solid that is used as an intermediate in the synthesis of other chemicals, such as pesticides and pharmaceuticals. 4-Nitropyridine is also used as a reagent in organic synthesis. It has been shown to be a potent inhibitor of the enzyme acetylcholinesterase, which is responsible for the breakdown of the neurotransmitter acetylcholine. This suggests that 4-nitropyridine may have potential as a therapeutic agent for the treatment of Alzheimer's disease. 4-Nitropyridine is also studied for its potential as a catalyst in various chemical reactions. It is an important compound in the field of organic chemistry and is being investigated for its potential applications in various fields, including medicine, agriculture, and materials science.'

Cross-References

ID SourceID
PubMed CID70734
CHEMBL ID4577515
SCHEMBL ID545380
MeSH IDM0149569

Synonyms (22)

Synonym
4-nitropyridine
1122-61-8
nsc30350
pyridine, 4-nitro-
nsc-30350
AKOS000267399
FT-0692561
4-nitro-pyridine
unii-59d3ds58zb
59d3ds58zb ,
nsc 30350
ai3-25255
SCHEMBL545380
FEXIEMAAKBNTFK-UHFFFAOYSA-N
DTXSID2074453
mfcd00054554
AS-35885
A925594
CHEMBL4577515
SB52565
SY029168
CS-0059175

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The mean elimination half-life of nifedipine prolonged significantly following diltiazem (2."( Dose dependent effect of diltiazem on the pharmacokinetics of nifedipine.
Fujimura, A; Hosoda, S; Kumagai, Y; Ohashi, K; Sakamoto, K; Sudo, T; Sugimoto, K; Tateishi, T; Toyo-oka, T; Toyosaki, N, 1989)		0.28

Bioavailability

ExcerptReferenceRelevance
"05) and bioavailability (0."( Factors affecting the absolute bioavailability of nifedipine.
Clarke, H; George, CF; Martin, U; Rashid, TJ; Renwick, AG; Waller, DG, 1995)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1524436Substrate activity at recombinant Haemophilus influenzae Chloramphenicol nitroreductase expressed in Escherichia coli assessed as initial rate of reaction at 150 uM measured at 30 sec interval for 5 mins in presence of NADPH at pH 8 under 37 degC by UV-vi2019Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
Investigating the promiscuity of the chloramphenicol nitroreductase from Haemophilus influenzae towards the reduction of 4-nitrobenzene derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (33.33)18.7374
1990's1 (11.11)18.2507
2000's1 (11.11)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.34 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.68 (4.65)
Search Engine Demand Index36.02 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.34)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (22.22%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (77.78%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-nitrobenzaldehyde
4-nitrobenzaldehyde: RN given refers to parent cpd. 4-nitrobenzaldehyde : A C-nitro compound that is benzaldehyde substituted at the para-position with a nitro group.		2.2110benzaldehydes;
C-nitro compound
4-nitrophenol
4-nitrophenol: RN given refers to parent cpd. mononitrophenol : A nitrophenol that is phenol carrying a single nitro substituent at unspecified position.. 4-nitrophenol : A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group.		2.21104-nitrophenolshuman xenobiotic metabolite;
mouse metabolite
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.1110isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
nifedipine
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.		4.6132C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.2110C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
dithionitrobenzoic acid
Dithionitrobenzoic Acid: A standard reagent for the determination of reactive sulfhydryl groups by absorbance measurements. It is used primarily for the determination of sulfhydryl and disulfide groups in proteins. The color produced is due to the formation of a thio anion, 3-carboxyl-4-nitrothiophenolate.. dithionitrobenzoic acid : An organic disulfide that results from the formal oxidative dimerisation of 2-nitro-5-thiobenzoic acid. An indicator used to quantify the number or concentration of thiol groups.		2.2110nitrobenzoic acid;
organic disulfide		indicator
nitrobenzene
nitrobenzene : A nitroarene consisting of benzene carrying a single nitro substituent. An industrial chemical used widely in the production of aniline.		2.2110nitroarene;
nitrobenzenes
1,2-dichloro-4-nitrobenzene
[no description available]		2.2110
4-nitroaniline
[no description available]		2.2110nitroanilinebacterial xenobiotic metabolite
2-nitrobenzaldehyde
2-nitrobenzaldehyde: structure given in first source. 2-nitrobenzaldehyde : Benzaldehyde substituted at the ortho-position with a nitro group.		2.2110benzaldehydes;
C-nitro compound
nitrohexane
nitrohexane: formed by deliberate nitrosation of corn; RN given refers to cpd with unspecified nitro locant; RN & N1 from 9th CI Form Index. 1-nitrohexane : A primary nitroalkane that is hexane substituted by a nitro group at position 1.		2.2110primary nitroalkanehuman urinary metabolite
4-nitropyridine 1-oxide
[no description available]		1.9710
nsc 520594
[no description available]		2.2110
diltiazem
Diltiazem: A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.. diltiazem : A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.		3.36115-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateantihypertensive agent;
calcium channel blocker;
vasodilator agent
4-nitrobenzyl bromide
4-nitrobenzyl bromide: structure given in first source. 4-nitrobenzyl bromide : A C-nitro compound that consists of nitrobenzene bearing a bromomethyl substituent at the para-position.		2.2110benzyl bromides;
C-nitro compound		allergen;
sensitiser
4-nitrobenzyl alcohol
4-nitrobenzyl alcohol : A member of the class of benzyl alcohols that is benzyl alcohol substituted at the para-position by a nitro group.		2.2110benzyl alcohols;
C-nitro compound		xenobiotic metabolite
4-nitrophenyl butyrate
p-nitrophenyl butyrate : A butyrate ester resulting from the formal condensation of the hydroxy group of 4-nitrophenol with the carboxy group of butyric acid.		2.2110butyrate ester;
C-nitro compound
1-(4-nitrophenyl)piperazine
1-(4-nitrophenyl)piperazine: structure in first source		2.2110
4,5-dimethoxy-2-nitrobenzaldehyde
[no description available]		2.2110aromatic ether;
C-nitro compound
nitrofurantoin
Nitrofurantoin: A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.. nitrofurantoin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.		2.2110imidazolidine-2,4-dione;
nitrofuran antibiotic;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic		antibacterial drug;
antiinfective agent;
hepatotoxic agent
indocyanine green
Indocyanine Green: A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.		3.36111,1-diunsubstituted alkanesulfonate;
benzoindole;
cyanine dye
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		1.9710organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials