2-thio-6-azathymine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	1263666
CHEMBL ID	3272983
SCHEMBL ID	130106
SCHEMBL ID	9524752
MeSH ID	M0047601

Synonyms (70)

Synonym
6-methyl-3-sulfanyl-1,2,4-triazin-5-ol
STK721922
nsc-1609
6-methyl-3-thio-as-triazine-3,4h)-dione
nsc1609
6-azathiothymine
6-aza-2-thiothymine ,
nsc-38618
nsc38618
NCIOPEN2_001908
SDCCGMLS-0065562.P001
615-76-9
nsc102906
nsc-102906
6-aza-2-thiothymine, 99%
EC-000.1632
3-mercapto-6-methyl-1,2,4-triazin-5(2h)-one
1,2,4-triazin-5(2h)-one, 3,4-dihydro-6-methyl-3-thioxo-
as-triazine-3,5(2h,4h)-dione, 6-methyl-3-thio-
nsc 1609
as-triazin-5-ol, 3-mercapto-6-methyl-
2-thio-6-azathymine
nsc 38618
nsc 102906
3-mercapto-6-methyl-as-triazin-5-ol
6-methyl-3-thio-as-triazine-3,5(2h,4h)-dione
3,4-dihydro-6-methyl-3-thioxo-1,2,4-triazin-5(2h)-one
einecs 210-445-4
AKOS000270509
3-mercapto-6-methyl-1,2,4-triazin-5(4h)-one
F0896-0373
6-methyl-3-thioxo-3,4-dihydro-2h-[1,2,4]triazin-5-one
F1285-1861
inchi=1/c4h5n3os/c1-2-3(8)5-4(9)7-6-2/h1h3,(h2,5,7,8,9)
nkopqosbrolofp-uhfffaoysa-
AKOS000122766
AKOS002860534
AKOS002286303
6-methyl-3-thioxo-2h-1,2,4-triazin-5-one
A833313
6-methyl-3-sulfanyl-1,2,4-triazin-5(4h)-one
STK789032
6-methyl-3-sulfanylidene-2h-1,2,4-triazin-5-one
6-methyl-3-thioxo-2h-[1,2,4]triazin-5-one
6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2h)-one
unii-rhh0rio9kf
rhh0rio9kf ,
FT-0620950
CHEMBL3272983
STL477637
SCHEMBL130106
SCHEMBL9524752
6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2h)-one #
6-methyl-3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazine
DTXSID30210473
CCG-231082
mfcd00006458
Z56887779
6-methyl-3-sulfanylidene-2,3,4,5-tetrahydro-1,2,4-triazin-5-one
AS-69474
3-mercapto-5-hydroxy-6-methyl-1,2,4-triazine
5-methyl-2-thio-6-azauracil
2-thio-6-azathymine;6-azathiothymine;6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2h)-one
BCP31508
SB73472
D94647
CS-0071621
6-methyl-3-sulfanyl-4,5-dihydro-1,2,4-triazin-5-one
EN300-25132
PD000819

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1148822	Toxicity in trophozoite Plasmodium berghei infected in sc dosed mouse administered as single dose 72 hrs after parasite infection	1976	Journal of medicinal chemistry, Jun, Volume: 19, Issue:6	Antimalarials. 3. 1,2,4-Triazines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (6.25)	18.7374
1990's	3 (18.75)	18.2507
2000's	6 (37.50)	29.6817
2010's	5 (31.25)	24.3611
2020's	1 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.13 (24.57)
Research Supply Index	2.83 (2.92)
Research Growth Index	4.96 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.13)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
benzoic acid Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.. benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.. aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.	2.02	1	benzoic acids	algal metabolite; antimicrobial food preservative; drug allergen; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; human xenobiotic metabolite; plant metabolite
cytosine [no description available]	2.15	1	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
thymine [no description available]	3.97	13	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite
alpha-cyano-4-hydroxycinnamate alpha-cyano-4-hydroxycinnamate: specific inhibitor of pyruvate transport in rat liver mitochondria & human erythrocytes; structure	2.43	2
anthralin Anthralin: An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.. anthralin : An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.	2.02	1	anthracenes	antipsoriatic
2,5-dihydroxybenzoic acid 2,5-dihydroxybenzoic acid: RN given refers to parent cpd; a oxidative product of saligenin. 2,5-dihydroxybenzoic acid : A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.	2.05	1	dihydroxybenzoic acid	EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; fungal metabolite; human metabolite; MALDI matrix material; mouse metabolite
anthranilamide [no description available]	2.02	1	substituted aniline
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.6	1	copper group element atom; elemental gold
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2	1	benzenes; phenyl acetates
haba 2-(4-hydroxyphenylazo)benzoic acid : An azo compound that is azobenzene in which one phenyl group is substituted at position 4 by a hydroxy group, while the other phenyl group is substituted at position 2 by a carboxy group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.	2.41	2
7-amino-4-methylcoumarin 7-amino-4-methylcoumarin: RN given refers to parent cpd	1.99	1	7-aminocoumarins	fluorochrome
singlet oxygen Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.	2.49	2	chalcogen; monoatomic oxygen; nonmetal atom	macronutrient
angiotensin ii Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).	2.01	1	amino acid zwitterion; angiotensin II	human metabolite
n-acetylneuraminic acid N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518). N-acetylneuraminic acid : An N-acylneuraminic acid where the N-acyl group is specified as acetyl.	1.99	1	N-acetylneuraminic acids	antioxidant; bacterial metabolite; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; human metabolite; mouse metabolite
ammonium acetate ammonium acetate : An ammonium salt obtained by reaction of ammonia with acetic acid. A deliquescent white crystalline solid, it has a relatively low melting point (114degreeC) for a salt. Used as a food acidity regulator, although no longer approved for this purpose in the EU.	2	1	acetate salt; ammonium salt	buffer; food acidity regulator
sinapinic acid sinapinic acid: a matrix for matrix-assisted laser desorption technique for protein MW determination; a constituent of propolis. trans-sinapic acid : A sinapic acid in which the double bond has trans-configuration.	1.99	1	sinapic acid	MALDI matrix material; plant metabolite
2-thiothymine 2-thiothymine: structure given in first source	2.49	2
2-thiocytosine 4-amino-2-mercaptopyrimidine: structure in first source	2.15	1
indoleacrylic acid indoleacrylic acid: Russian drug; natural auxin from lentil roots; RN given refers to parent cpd without isomeric designation	2.02	1
dynorphins Dynorphins: A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.	2	1
oligonucleotides [no description available]	1.98	1
glycolipids [no description available]	2	1
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	1.99	1	benzenes; hydroxycoumarin; methyl ketone

Condition	Relationship Strength	Studies
Infections, Plasmodium [description not available]	1.95	1
Malaria, Avian Any of a group of infections of fowl caused by protozoa of the genera PLASMODIUM, Leucocytozoon, and Haemoproteus. The life cycles of these parasites and the disease produced bears strong resemblance to those observed in human malaria.	1.95	1
Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	1.95	1
Anemia, Fanconi [description not available]	2.13	1
Fanconi Anemia Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)	2.13	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2	1

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