Compounds > 2-thiothymine
Page last updated: 2024-12-09

2-thiothymine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-thiothymine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID720471
CHEMBL ID3186154
SCHEMBL ID25450
SCHEMBL ID8139808
MeSH IDM0265456

Synonyms (56)

Synonym
5-methyl-2-thioxo-1h-pyrimidin-4-one
4(1h)-pyrimidinone, 2,3-dihydro-5-methyl-2-thioxo-
AC-907/25004441
5-methyl-2-sulfanylpyrimidin-4-ol
5-methyl-2-thiouracil
thiothymine
636-26-0
2-thiothymine
thymine, 2-thio-
4(1h)-pyrimidinone,3-dihydro-5-methyl-2-thioxo-
nsc9377
uracil, 5-methyl-2-thio-
nsc-9377
ai3-26055
ccris 6069
2,3-dihydro-5-methyl-2-thioxo-4(1h)-pyrimidinone
nsc 9377
5-methyl-2-thioxo-2,3-dihydropyrimidin-4(1h)-one
inchi=1/c5h6n2os/c1-3-2-6-5(9)7-4(3)8/h2h,1h3,(h2,6,7,8,9)
zlaqatdnglkiev-uhfffaoysa-
5-methyl-2-sulfanylidene-1h-pyrimidin-4-one
M0994
4-hydroxy-5-methyl-2-thiopyrimidine
AKOS002263996
A834443
2-mercapto-5-methylpyrimidin-4-ol
ksc-27-034a
KUC108901N
4-hydroxy-5-methyl-2-mercaptopyrimidine
dtxsid9025665 ,
tox21_202899
cas-636-26-0
NCGC00260445-01
dtxcid505665
AKOS006228865
5-methyl-2-mercaptopyrimidin-4-ol
F3095-3971
FT-0620619
SCHEMBL25450
SCHEMBL8139808
5-methyl-2-thioxo-2,3-dihydro-1h-pyrimidin-4-one
5-methyl-2 thiouracil
2-thio-thymine
5-methyl-2-thioxo-2,3-dihydro-4(1h)-pyrimidinone #
DS-3047
CHEMBL3186154
J-515497
mfcd00009777
AC-8175
5-methyl-2-thiouracil, 98%
5-methyl-4-oxy-2-thiopyrimidine
5-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one
CS-W018293
2,3-dihydro-5-methyl-2-thioxopyrimidin-4(1h)-one
EN300-97160
SY050032
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency34.44620.000714.592883.7951AID1259392
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency62.03820.003041.611522,387.1992AID1159552; AID1159553; AID1159555
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency6.12550.001530.607315,848.9004AID1224841
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency61.81830.001024.504861.6448AID743215
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency61.81830.023723.228263.5986AID743222
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency68.72910.001723.839378.1014AID743083
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency58.45690.057821.109761.2679AID1159526; AID1159528
heat shock protein beta-1Homo sapiens (human)Potency55.09560.042027.378961.6448AID743210
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's4 (28.57)29.6817
2010's8 (57.14)24.3611
2020's1 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.46 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.85 (4.65)
Search Engine Demand Index24.72 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.46)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cytosine
[no description available]		2.1510aminopyrimidine;
pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
thymine
[no description available]		4.08140pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite
thymidine
[no description available]		2.4120pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		2.0210amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
acetonitrile
acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.		2.110aliphatic nitrile;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent
2-aminopurine
2-Aminopurine: A purine that is an isomer of ADENINE (6-aminopurine).. aminopurine : Any purine having at least one amino substituent.. 2-aminopurine : The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.		2.72302-aminopurines;
nucleobase analogue		antimetabolite
2,6-diaminopurine
9H-purine-2,6-diamine : A member of the class of 2,6-diaminopurines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by amino groups.		2.72302,6-diaminopurines;
primary amino compound		antineoplastic agent
singlet oxygen
Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.		7.4920chalcogen;
monoatomic oxygen;
nonmetal atom		macronutrient
2-thio-6-azathymine
[no description available]		2.4920
thiouracil
Thiouracil: Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis.. thiouracil : A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.		2.8330nucleobase analogue;
thiocarbonyl compound		antithyroid drug;
metabolite
2-thiocytosine
4-amino-2-mercaptopyrimidine: structure in first source		2.1510
2-thiothymidine
2-thiothymidine: structure given in first source		2.0210
2-deoxyribose 1-phosphate, (alpha-d-erythro)-isomer
[no description available]		2.02102-deoxy-D-ribofuranose 1-phosphate
oligonucleotides
[no description available]		7.7930
ConditionIndicatedRelationship StrengthStudiesTrials