1-oleoyl-2-stearoylphosphatidylcholine profile

## 1-Oleoyl-2-stearoylphosphatidylcholine (OSP-PC)

**What is it?**

1-Oleoyl-2-stearoylphosphatidylcholine (OSP-PC) is a **phospholipid**, a type of fat-like molecule that is a major component of cell membranes. It's a **synthetic phospholipid** with a specific structure:

* **1-Oleoyl:** It has an oleic acid molecule attached to the first glycerol position. Oleic acid is an unsaturated fatty acid with a single double bond.
* **2-Stearoyl:** It has a stearic acid molecule attached to the second glycerol position. Stearic acid is a saturated fatty acid with no double bonds.
* **Phosphatidylcholine:** The third glycerol position is linked to a phosphate group, which is then attached to choline.

**Why is it important for research?**

OSP-PC is important in research due to several reasons:

1. **Cell membrane model:** Because it's a major component of cell membranes, OSP-PC is used as a model system to study the properties of membranes. This includes research on:
* **Membrane fluidity:** OSP-PC's combination of saturated and unsaturated fatty acids contributes to the fluidity and flexibility of membranes.
* **Lipid rafts:** It plays a role in the formation of lipid rafts, which are specialized microdomains within cell membranes involved in various cellular processes.
* **Drug delivery:** Researchers investigate how OSP-PC interacts with drugs and how it can be used to deliver drugs into cells.

2. **Drug development:** Researchers use OSP-PC to create liposomes, which are tiny spheres made of phospholipid bilayers. These liposomes are used to deliver drugs, vaccines, and other therapies. The specific structure of OSP-PC can influence the stability, targeting, and release of these therapies.

3. **Biophysical studies:** OSP-PC is used in various biophysical studies to investigate the interactions between lipids, proteins, and other molecules. This allows researchers to gain a deeper understanding of how these molecules function within cell membranes.

4. **Food science:** OSP-PC is also used in food science, as it can enhance the texture and stability of food products.

**In summary, OSP-PC is a versatile and valuable tool for researchers studying cell membranes, drug delivery, biophysical processes, and even food science.** Its specific structure and properties make it a crucial component in understanding and manipulating these fields.

1-oleoyl-2-stearoylphosphatidylcholine: RN given refers to the (Z)-isomer; RN for cpd without isomeric designation not available 4/91 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	6449784
MeSH ID	M0186131

Synonym
7319-55-3
3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium, 4-hydroxy-n,n,n-trimethyl-10-oxo-7-((1-oxooctadecyl)oxy)-, inner salt, 4-oxide, (z)-
1-oleoyl-2-stearoylphosphatidylcholine
[2-octadecanoyloxy-3-[(z)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (45.45)	18.2507
2000's	6 (54.55)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ethylene glycol Ethylene Glycol: A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.. ethanediol : Any diol that is ethane or substituted ethane carrying two hydroxy groups.. ethylene glycol : A 1,2-glycol compound produced via reaction of ethylene oxide with water.	2.05	1	ethanediol; glycol	metabolite; mouse metabolite; solvent; toxin
1,2-dipalmitoylphosphatidylcholine 1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	2.05	1
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.01	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
1,2-distearoyllecithin [no description available]	2.05	1
dimyristoylphosphatidylglycerol [no description available]	1.97	1
imatinib mesylate imatinib methanesulfonate : A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.	2.05	1	methanesulfonate salt	anticoronaviral agent; antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
oleic acid Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.	2.05	1	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent
elaidic acid [no description available]	2.05	1	octadec-9-enoic acid	food component
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	1.97	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
cholesteryl oleate cholesteryl oleate: RN given refers to ((Z)-isomer). cholesteryl oleate : The (Z)-stereoisomer of cholesteryl octadec-9-enoate.	1.98	1	CE(18:1); cholesteryl octadec-9-enoate	mouse metabolite
1,2-oleoylphosphatidylcholine 1,2-oleoylphosphatidylcholine: RN given refers to (Z,Z)-isomer. dioleoyl phosphatidylcholine : A phosphatidylcholine in which the phosphatidyl acyl groups are both oleoyl.	2	1	phosphatidylcholine(1+)
dimyristoylphosphatidylcholine 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).	1.97	1	1,2-diacyl-sn-glycero-3-phosphocholine; phosphatidylcholine 28:0; tetradecanoate ester	antigen; mouse metabolite
triolein Triolein: (Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.. triolein : A triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.	1.98	1	triglyceride	Caenorhabditis elegans metabolite; plant metabolite
1-palmitoyl-2-oleoylphosphatidylcholine 1-palmitoyl-2-oleoylphosphatidylcholine: RN given refers to (Z)-isomer	2.05	1
1-oleoyl-2-palmitoylphosphatidylcholine 1-oleoyl-2-palmitoylphosphatidylcholine: RN given refers to (Z)-isomer	2.05	1
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	3.8	11	1,2-diacyl-sn-glycero-3-phosphocholine
phosphatidylcholines 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine: RN given refers to (Z)-isomer. 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine : A phosphatidylcholine 36:1 in which the phosphatidyl acyl groups at positions 1 and 2 are stearoyl and oleoyl respectively.	2.93	4	1-acyl-2-oleoyl-sn-glycero-3-phosphocholine betaine; 1-octadecanoyl-2-octadecenoyl-sn-glycero-3-phosphocholine
glycolipids [no description available]	1.98	1

Condition	Relationship Strength	Studies
B. burgdorferi Infection [description not available]	2.42	2
Lyme Disease An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.	2.42	2
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	1.99	1

1-oleoyl-2-stearoylphosphatidylcholine

Description

Cross-References

Synonyms (4)

Research

Studies (11)

Market Indicators

Research Demand Index: 11.91

Study Types