technetium-tc-99m-sulfur-colloid and Splenosis

Splenosis is defined as the autotransplantation of splenic tissue to abnormal locations after splenic injury. Although abdominal splenosis is the most common form and is usually discovered at laparotomy, thoracic splenosis is less common and occurs as an asymptomatic peripheral pulmonary nodule, incidentally discovered on a routine chest radiograph. Given the long interval between the initial trauma and its discovery, thoracic splenosis is rarely considered in the differential diagnosis of left-sided, pleural-based pulmonary nodules or masses. The diagnosis is often a result of surgery. The authors report an additional case of thoracic splenosis, review the literature, and discuss nonsurgical diagnostic methods.

Topics: Abdominal Injuries; Humans; Male; Middle Aged; Radiography, Thoracic; Radionuclide Imaging; Radiopharmaceuticals; Splenosis; Technetium Tc 99m Sulfur Colloid; Thorax; Tomography, X-Ray Computed; Wounds, Gunshot

The development of splenosis is a known consequence of splenic rupture. A case is presented of acute appendicitis in a patient with a past history of abdominal trauma who required laparotomy for unknown reasons. During appendicectomy a mass was found in the mesoappendix which proved to be evidence of splenosis.

Topics: Abdominal Pain; Adult; Appendectomy; Appendicitis; Humans; Male; Radionuclide Imaging; Spleen; Splenectomy; Splenosis; Technetium Tc 99m Sulfur Colloid

Splenosis is a rare condition defined as seeding and autotransplantation of splenic tissue, typically after blunt abdominal trauma (e.g. from road traffic collision). Sites of splenosis ranging from intrathoracic to intrapelvic have been reported, and symptoms vary greatly depending on the site and size of lesions. We present the use of Tc-99m sulphur colloid SPECT/CT in diagnosing a case of multiple abdominopelvic splenosis as the cause of new-onset tenesmus and constipation, which was initially thought to be due to colorectal malignancy, 47 years following the initial abdominal trauma.

Topics: Constipation; Humans; Male; Middle Aged; Radiopharmaceuticals; Rectal Diseases; Splenosis; Technetium Tc 99m Sulfur Colloid; Tomography, Emission-Computed, Single-Photon

Splenosis, the heterotopic autotransplantion of splenic tissue, is a common benign condition among patients with a history of splenic trauma. Most cases of splenosis are intra-abdominal due to direct seeding of surrounding structures, although these ectopic rests may occur almost anywhere in the body, and its diffuse nature may raise the suspicion of metastatic cancer. Confirmation of splenic tissue can be made by technetium-99m (Tc-99m) sulfur colloid scintigraphy or with Tc-99m heat-damaged red blood cells; however, in some cases, biopsy may be required for definitive diagnosis. Here, the authors present a patient with a remote history of posttraumatic splenectomy who was discovered to have multiple intra-abdominal nodules by CT scan. A diagnosis of diffuse metastatic disease was initially considered before a diagnosis of intraabdominal splenosis was ultimately made with the aid of Tc-99m sulfur colloid single-positron emission computed tomography (SPECT) and computed tomography imaging.

Topics: Abdomen; Abdominal Neoplasms; Diagnosis, Differential; Humans; Male; Middle Aged; Splenosis; Technetium Tc 99m Sulfur Colloid; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Heterotropic splenic tissue in renal fossa is characteristically asymptomatic and is usually an incidental finding that has been reported to mimic renal or adrenal tumors. A 55-year-old man with renal cell carcinoma had undergone radical nephrectomy together with splenectomy because of disrupture of the splenic capsule. During a follow-up examination, three nodules were detected by computed tomography scan in the splenorenal area and they slowly enlarged. Although local recurrence was highly suspected, we decided to rule out splenosis. We successfully diagnosed these masses as ectopic splenic tissues by a technetium sulfur colloid scan and unnecessary surgical exploration was avoided.

Topics: Carcinoma, Renal Cell; Diagnosis, Differential; Follow-Up Studies; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Nephrectomy; Positron-Emission Tomography; Radiopharmaceuticals; Splenectomy; Splenosis; Technetium Tc 99m Sulfur Colloid; Tomography, X-Ray Computed

Topics: Diagnosis, Differential; Female; Humans; Middle Aged; Ovarian Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Splenectomy; Splenosis; Technetium Tc 99m Sulfur Colloid

Topics: Adult; Choristoma; Humans; Male; Peritoneal Diseases; Radionuclide Imaging; Radiopharmaceuticals; Spleen; Splenectomy; Splenosis; Technetium Tc 99m Sulfur Colloid

Topics: Accidents, Traffic; Adult; Erythrocytes; Female; Humans; Radionuclide Imaging; Radiopharmaceuticals; Respiratory Tract Infections; Splenectomy; Splenosis; Technetium Tc 99m Sulfur Colloid; Tomography, X-Ray Computed

Topics: Abdomen; Adult; Diagnosis, Differential; Gastrointestinal Hemorrhage; Humans; Male; Radionuclide Imaging; Radiopharmaceuticals; Splenosis; Technetium Tc 99m Sulfur Colloid

Topics: Abdominal Injuries; Adolescent; Adult; beta-Thalassemia; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Purpura, Thrombocytopenic, Idiopathic; Splenectomy; Splenosis; Technetium Tc 99m Sulfur Colloid; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

Intrathoracic splenosis is a rare diagnosis that is usually made following an invasive procedure. Although radiographic and CT findings are nonspecific, these findings combined with a history of splenic injury should suggest the possibility of this diagnosis. We present a patient with intrathoracic splenosis diagnosed on the basis of a technetium Tc 99m heat-damaged RBC scan following false-negative technetium Tc 99m sulfur colloid scan results.

Topics: Diaphragm; Erythrocytes; False Negative Reactions; HIV Seropositivity; Humans; Male; Middle Aged; Pleura; Postoperative Complications; Radionuclide Imaging; Splenic Rupture; Splenosis; Technetium; Technetium Tc 99m Sulfur Colloid; Tomography, X-Ray Computed

An unusual cause of abdominal soft-tissue masses is accessory splenic tissue. The Tc-99m-sulfur colloid liver-spleen scan is a valuable adjunct in making this diagnosis. This report describes a 47-year-old man who had an abdominal magnetic resonance imaging (MRI) scan as part of a pretransplant evaluation and was found to have multiple soft-tissue masses in the posterior aspect of his abdomen. His history was pertinent for a traumatic rupture of the spleen at the age of 12 years, for which he required a splenectomy. He had no symptoms or physical findings to indicate a lymphoproliferative disorder or other malignant process. His peripheral blood smear was remarkable for the absence of Howell-Jolly bodies. The nuclear scan confirmed the presence of uptake in the soft-tissue masses seen on MRI scan. This finding supports our diagnosis of splenosis in a man with a history of traumatic splenic rupture as a child.

Topics: Humans; Liver; Liver Transplantation; Magnetic Resonance Imaging; Male; Middle Aged; Preoperative Care; Radionuclide Imaging; Spleen; Splenosis; Technetium Tc 99m Sulfur Colloid

Topics: Abdomen; Humans; Liver Cirrhosis; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Splenectomy; Splenic Rupture; Splenosis; Technetium Tc 99m Sulfur Colloid

Thoracic splenosis is the autotransplantation of splenic tissue into the pleural cavity, usually following traumatic injury that simultaneously involves the spleen and diaphragm. Intrathoracic splenosis is an uncommonly reported phenomenon. We present a case of intrathoracic splenosis in a patient with a chronic aortic pseudoaneurysm, both detected, incidentally, three decades after the traumatic event. The diagnosis of thoracic splenosis can be confirmed noninvasively, using 99mTc sulfur colloid nuclear scintigraphy.

Topics: Aneurysm, False; Aorta, Thoracic; Humans; Male; Middle Aged; Radiography, Thoracic; Splenosis; Technetium Tc 99m Sulfur Colloid; Thorax; Time Factors; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

A 45-year-old man, seropositive for hepatitis C, was examined because his liver was palpable well below the costal margin. A CT examination revealed multiple nodules within the liver and also several sites of ectopic tissue. The patient had a splenectomy 25 years before. A radiocolloid study showed uptake, consistent with splenosis, in the thorax, abdomen, pelvis, and possibly the left arm. The magnitude of the ectopic tissue, and its multiple locations, indicated the ability of splenic cells to grow in a variety of body sites.

Topics: Humans; Liver; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Splenectomy; Splenosis; Technetium Tc 99m Sulfur Colloid; Time Factors; Tomography, X-Ray Computed

Topics: Autoimmune Diseases; Humans; Male; Middle Aged; Radionuclide Imaging; Splenosis; Technetium Tc 99m Sulfur Colloid; Thrombocytopenia

The authors present a case that demonstrates the continued high sensitivity of Tc-99m SC liver-spleen imaging for thoracic splenosis. A patient with profound weight loss, positive PPD and left upper lobe lung density on a chest radiograph was felt to have a strong clinical suspicion of a malignant pulmonary lesion. Two needle biopsies of the lesion were consistent with splenic tissue. Transbronchial biopsy of the right lower lobe lung revealed metastatic adenocarcinoma of an unknown origin. A Tc-99m SC liver-spleen scan of the abdomen and thorax indicated the lung density was consistent with thoracic splenosis.

Topics: Adenocarcinoma; Adult; Humans; Liver; Lung Diseases; Lung Neoplasms; Male; Neoplasms, Unknown Primary; Radionuclide Imaging; Sensitivity and Specificity; Spleen; Splenosis; Technetium Tc 99m Sulfur Colloid; Tomography, X-Ray Computed