Compounds > taxuyunnanine c

Page last updated: 2024-11-11

taxuyunnanine c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	5321771
CHEMBL ID	436993
CHEBI ID	15208
MeSH ID	M0478807

Synonyms (7)

Synonym
CHEBI:15208 ,
taxa-4(20),11-diene-2alpha,5alpha,10beta,14beta-tetrayl tetraacetate
taxuyunnanin c
taxuyunnanine c
CHEMBL436993
[(1s,2s,3s,5s,8s,10s,14s)-2,10,14-triacetyloxy-8,12,15,15-tetramethyl-4-methylidene-5-tricyclo[9.3.1.03,8]pentadec-11-enyl] acetate
Q27109022

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
taxane diterpenoid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay ID	Title	Year	Journal	Article
AID399200	Reversal of multidrug resistance in human 2780AD cells assessed as [3H]vincristine accumulation at 1 ug/mL after 2 hrs relative to verapamil	2004	Journal of natural products, Jan, Volume: 67, Issue:1	Production of biologically active taxoids by a callus culture of Taxus cuspidata.
AID399201	Reversal of multidrug resistance in human 2780AD cells assessed as [3H]vincristine accumulation at 10 ug/mL after 2 hrs relative to verapamil	2004	Journal of natural products, Jan, Volume: 67, Issue:1	Production of biologically active taxoids by a callus culture of Taxus cuspidata.
AID307735	Growth inhibition of human HepG2 cells	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
AID399197	Reversal of multidrug resistance in human 2780AD cells assessed as [3H]vincristine accumulation at 1 ug/mL after 2 hrs relative to control	2004	Journal of natural products, Jan, Volume: 67, Issue:1	Production of biologically active taxoids by a callus culture of Taxus cuspidata.
AID307733	Growth inhibition of human WI38 cells	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
AID307734	Growth inhibition of human VA13 cells	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
AID399198	Reversal of multidrug resistance in human 2780AD cells assessed as [3H]vincristine accumulation at 10 ug/mL after 2 hrs relative to control	2004	Journal of natural products, Jan, Volume: 67, Issue:1	Production of biologically active taxoids by a callus culture of Taxus cuspidata.
AID399196	Reversal of multidrug resistance in human 2780AD cells assessed as [3H]vincristine accumulation at 0.1 ug/mL after 2 hrs relative to control	2004	Journal of natural products, Jan, Volume: 67, Issue:1	Production of biologically active taxoids by a callus culture of Taxus cuspidata.
AID399199	Reversal of multidrug resistance in human 2780AD cells assessed as [3H]vincristine accumulation at 0.1 ug/mL after 2 hrs relative to verapamil	2004	Journal of natural products, Jan, Volume: 67, Issue:1	Production of biologically active taxoids by a callus culture of Taxus cuspidata.
AID307732	Inhibition of Pgp in multidrug-resistant human 2780AD cells assessed as calcein accumulation at 25 ug/mL relative to control	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
AID307731	Inhibition of Pgp in multidrug-resistant human 2780AD cells assessed as calcein accumulation at 2.5 ug/mL relative to control	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
AID307730	Inhibition of Pgp in multidrug-resistant human 2780AD cells assessed as calcein accumulation at 0.25 ug/mL relative to control	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (60.00)	29.6817
2010's	6 (40.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.54 (24.57)
Research Supply Index	2.83 (2.92)
Research Growth Index	4.37 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.54)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
salicylic acid Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).	7.06	1	0	monohydroxybenzoic acid	algal metabolite; antifungal agent; antiinfective agent; EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor; keratolytic drug; plant hormone; plant metabolite
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	2.43	2	0	aromatic ether; nitrile; polyether; tertiary amino compound
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	2.03	1	0
vincristine [no description available]	2.03	1	0	acetate ester; formamides; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; tertiary alcohol; tertiary amino compound; vinca alkaloid	antineoplastic agent; drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
sucrose Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.	7.44	2	0	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	3.53	8	0	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.44	2	0	benzenes; phenyl acetates
alkenes [no description available]	2.11	1	0
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.77	3	0	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.02	1	0	D-glucopyranose	epitope; mouse metabolite
fluorexon fluorexon: structure	2.03	1	0	xanthene dye	fluorochrome
baccatin iii [no description available]	2.11	1	0	acetate ester; benzoate ester; tetracyclic diterpenoid	plant metabolite
10-deacetylbaccatine iii 10-deacetylbaccatine III: structure given in first source	2.11	1	0	secondary alpha-hydroxy ketone; tetracyclic diterpenoid
gamma-sitosterol clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.	2.11	1	0	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols	marine metabolite; plant metabolite
cytellin cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982	2.11	1	0
jasmonic acid jasmonic acid: a derivative of alpha-linolenic acid that has a role in plant response to herbivory analogous to the role of prostanoids in inflammation in mammals;. jasmonic acid : An oxo monocarboxylic acid that is (3-oxocyclopentyl)acetic acid substituted by a (2Z)-pent-2-en-1-yl group at position 2 of the cyclopentane ring.	3.12	5	0	oxo monocarboxylic acid	jasmonates; plant metabolite
methyl jasmonate [no description available]	7.44	2	0