Assay ID | Title | Year | Journal | Article |
AID315721 | Metabolic stability assessed as half life in rat liver microsomes | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption. |
AID352732 | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from NPC1L1 in human enterocyte | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. |
AID352735 | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from NPC1L1 in guinea pig enter | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. |
AID1211344 | Drug level in methionine and choline deficient fed Sprague-Dawley rat bile treated with ezetimibe at 10 mg/kg, po after 120 mins by LC-MS/MS method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. |
AID315718 | Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membrane | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption. |
AID352737 | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from NPC1L1 in rhesus monkey en | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. |
AID1211338 | Drug level in methionine and choline deficient fed Sprague-Dawley rat plasma treated with ezetimibe at 10 mg/kg, iv after 40 mins by LC-MS/MS method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. |
AID352736 | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from NPC1L1 in dog enterocyte b | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. |
AID1211332 | Drug level in methionine and choline deficient fed Sprague-Dawley rat plasma treated with ezetimibe at 10 mg/kg, po after 40 mins by LC-MS/MS method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. |
AID1211335 | Drug level in methionine and choline deficient fed Sprague-Dawley rat plasma treated with ezetimibe at 10 mg/kg, po after 120 mins by LC-MS/MS method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. |
AID1211327 | Drug level in methionine and choline deficient fed Sprague-Dawley rat urine treated with ezetimibe at 10 mg/kg, iv after 120 mins by LC-MS/MS method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. |
AID352738 | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from NPC1L1 in pig enterocyte b | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. |
AID352731 | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human recombinant NPC1L1 e | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. |
AID181919 | Percent inhibition of 14C]cholesterol absorption into plasma using cholesterol absorption assay in rats at the dose of 10 ug/Kg | 2002 | Bioorganic & medicinal chemistry letters, Feb-11, Volume: 12, Issue:3
| Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors. |
AID352734 | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from NPC1L1 in hamster enterocy | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. |
AID86018 | Compound was tested for percent reduction of liver cholesterol esters absorption in cholesterol fed hamster model at a dose of 3 mg/kg/day | 1998 | Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
| Sugar-substituted 2-azetidinone cholesterol absorption inhibitors: enhanced potency by modification of the sugar. |
AID1211341 | Drug level in methionine and choline deficient fed Sprague-Dawley rat plasma treated with ezetimibe at 10 mg/kg, iv after 120 mins by LC-MS/MS method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. |
AID352733 | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from NPC1L1 in rat enterocyte b | 2009 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11
| Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. |
AID86158 | Compound was tested for percent reduction of serum cholesterol absorption in cholesterol fed hamster model at a dose of 3 mg/kg/day | 1998 | Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
| Sugar-substituted 2-azetidinone cholesterol absorption inhibitors: enhanced potency by modification of the sugar. |
AID84707 | Dose required to inhibit cholesterol absorption in cholesterol fed hamster model | 1998 | Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
| Sugar-substituted 2-azetidinone cholesterol absorption inhibitors: enhanced potency by modification of the sugar. |
AID1211324 | Drug level in methionine and choline deficient fed Sprague-Dawley rat urine treated with ezetimibe at 10 mg/kg, po after 120 mins by LC-MS/MS method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. |
AID1211321 | Drug level in methionine and choline deficient fed Sprague-Dawley rat bile treated with ezetimibe at 10 mg/kg, iv after 30 to 90 mins by LC-MS/MS method | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |