| Assay ID | Title | Year | Journal | Article |
|---|
| AID73560 | Activity against rat brain Farnesyltransferase | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Ras farnesyltransferase: a new therapeutic target. |
| AID71316 | Inhibitory activity against recombinant human farnesyltransferase | 1997 | Journal of medicinal chemistry, Dec-05, Volume: 40, Issue:25
| Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods. |
| AID73121 | Compound ability to inhibit the transfer of [3H]- farnesyl from Farnesyltransferase to H-Ras-CVLS, a process that is mediated by FPT | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24
| (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent. |
| AID72823 | Inhibition of [3H]farnesyl pyrophosphate binding to human farnesyltransferase | 2003 | Bioorganic & medicinal chemistry letters, May-05, Volume: 13, Issue:9
| A novel metal-chelating inhibitor of protein farnesyltransferase. |
| AID74645 | Activity against Geranylgeranyl transferase type I | 1997 | Journal of medicinal chemistry, Sep-12, Volume: 40, Issue:19
| Ras farnesyltransferase: a new therapeutic target. |
| AID46504 | In vitro inhibition of Ras processing in COS cells | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
| Inhibitors of farnesyl protein transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11-dihydro[1]benzthiepin, benzoxepin, and benzazepin [4,3-b]pyridine ring system. |
| AID13685 | Compound was evaluated for maximum plasma concentration by administering orally at 25 mg/kg in mice | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor comp |
| AID71310 | In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]farnesyl from farnesyl pyrophosphate to H-Ras-CLVS. | 1998 | Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
| Inhibitors of farnesyl protein transferase. Synthesis and biological activity of amide and cyanoguanidine derivatives containing a 5,11-dihydro[1]benzthiepin, benzoxepin, and benzazepin [4,3-b]pyridine ring system. |
| AID74806 | Compound was tested for the inhibition of Geranylgeranyl transferase type I | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor comp |
| AID71307 | Compound was tested for the inhibition of Farnesyltransferase | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor comp |
| AID73123 | Inhibition of Farnesyltransferase | 1999 | Journal of medicinal chemistry, Jun-17, Volume: 42, Issue:12
| Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships. |
| AID11141 | Compound was evaluated for the area under the concentration - time curve by administering intravenously at 25 mg/kg in mice | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor comp |
| AID73400 | Inhibitory concentration against farnesyltransferase was determined | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
| Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy? |
| AID24329 | half life period is evaluated by administering intravenously at 25 mg/kg in mice | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor comp |
| AID46494 | Compound was tested for the inhibition of COS cells in monkey. | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor comp |
| AID46671 | Inhibiting the farnesylation of H-ras proteins in COS-7 monkey cells transiently expressing H-ras[Val12]-CVLS in the whole cell assay. | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24
| (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent. |
| AID14764 | Pharmacokinetic parameter area under the curve (0-24 hr) for the compound was evaluated in nude mice after oral administration. | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24
| (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent. |
| AID11142 | Compound was evaluated for the area under the concentration - time curve by administering orally at 25 mg/kg in mice | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor comp |
| AID493017 | Wombat Data for BeliefDocking | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor comp |
| AID1797226 | In Vitro Enzyme Assay of FPT from Article 10.1021/jm980462b: \\(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl prote | 1998 | Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24
| (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |