An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of protein geranylgeranyltransferase type I (EC 2.5.1.59).
ChEBI ID: 67267
| Member | Definition | Class |
|---|---|---|
| ggti-2133 | An organoammonium salt resulting from the mixing of equimolar amounts of GGTI-2133 free base and trifluoroacetic acid. An inhibitor of geranylgeranyltransferase type I. | GGTI-2133 |
| l 778,123 | The hydrochloride salt of L-778,123. It is a dual inhibitor of FPTase and GGPTase-I (IC50 of 2nM and 98nm, respectively) and exhibits anti-cancer properties. | L-778,123 hydrochloride |
| l 778,123 | A member of the class of imidazoles that is 1H-imidazole substituted by (4-cyanophenyl)methyl and [4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl groups at positions 1 and 5, respectively. It is a dual inhibitor of FPTase and GGPTase-I. | L-778,123 (free base) |
| massadine | An alkaloid isolated from Stylissa massa. | massadine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 34 (55.74) | 29.6817 |
| 2010's | 23 (37.70) | 24.3611 |
| 2020's | 4 (6.56) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (4.76%) | 5.53% |
| Reviews | 12 (19.05%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 48 (76.19%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Interferon beta | Homo sapiens (human) | Potency | 16.5388 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 16.5388 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Geranylgeranyl transferase type-1 subunit beta | Homo sapiens (human) | EC50 | 3.4460 | 2 | 2 |
| Protein farnesyltransferase subunit beta | Homo sapiens (human) | EC50 | 0.0920 | 1 | 1 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | EC50 | 3.4460 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Geranylgeranyl transferase type-1 subunit beta | Homo sapiens (human) | Inhibition | 0.0980 | 1 | 1 |
| Geranylgeranyl transferase type-1 subunit beta | Homo sapiens (human) | MIC | 1.0000 | 2 | 2 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | Inhibition | 0.0980 | 1 | 1 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | MIC | 1.0000 | 2 | 2 |