phosphoserine residue binding

Definition

Target type: molecularfunction

Binding to a phosphorylated serine residue within a protein. [GOC:ai]

Phosphoserine residue binding is a molecular function that involves the specific recognition and interaction of a protein or other molecule with a phosphoserine residue. This interaction is critical for various cellular processes, including signal transduction, protein regulation, and enzymatic activity.

Phosphoserine residues are formed by the phosphorylation of serine residues, a common post-translational modification that alters the properties of a protein. The phosphate group attached to the serine residue introduces a negatively charged group, creating a binding site for proteins or other molecules that contain positively charged residues or other groups that can interact with the phosphate group.

The molecular mechanism of phosphoserine residue binding involves the formation of non-covalent interactions, such as electrostatic interactions, hydrogen bonds, and hydrophobic interactions, between the phosphoserine residue and the binding site of the interacting molecule.

**Specific examples of the role of phosphoserine residue binding in cellular processes include:**

* **Signal transduction:** Phosphorylation of serine residues in signaling proteins often acts as a switch to activate or deactivate downstream signaling pathways. Proteins with phosphoserine residue binding domains recognize and interact with these phosphorylated proteins, relaying the signal further.
* **Protein regulation:** Phosphorylation of serine residues can alter the conformation and activity of proteins. Binding of proteins with phosphoserine residue binding domains can further regulate protein activity by stabilizing specific conformations or by recruiting other proteins to the complex.
* **Enzymatic activity:** Phosphorylation of serine residues in enzymes can modulate their catalytic activity. Binding of proteins with phosphoserine residue binding domains can activate or inhibit enzymatic activity by influencing substrate binding or product release.

**Proteins that contain phosphoserine residue binding domains are often involved in:**

* **Protein kinases:** These enzymes catalyze the phosphorylation of serine residues.
* **Phosphatases:** These enzymes remove the phosphate group from phosphoserine residues.
* **Scaffolding proteins:** These proteins bind to multiple signaling proteins and organize them into signaling complexes.
* **Transcription factors:** These proteins bind to DNA and regulate gene expression.

**Overall, phosphoserine residue binding is a fundamental molecular mechanism that plays a crucial role in a wide range of cellular processes. It is essential for maintaining cellular homeostasis and regulating cellular responses to external stimuli.**'
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Proteins (3)

Compounds (10)