14-3-3 protein eta

A 14-3-3 protein eta that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04917]

Synonyms

Protein AS1

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	1 (50.00)	2.80

Compounds (2)

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
arsenic trioxide	Homo sapiens (human)	Kd	110.0000	1	1
r18 peptide	Homo sapiens (human)	Kd	0.0700	1	1

Enables

This protein enables 10 target(s):

Target	Category	Definition
actin binding	molecular function	Binding to monomeric or multimeric forms of actin, including actin filaments. [GOC:clt]
insulin-like growth factor receptor binding	molecular function	Binding to an insulin-like growth factor receptor. [GOC:jl]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
sodium channel regulator activity	molecular function	Binds to and modulates the activity of a sodium channel. [GOC:mah]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein domain specific binding	molecular function	Binding to a specific domain of a protein. [GOC:go_curators]
nuclear glucocorticoid receptor binding	molecular function	Binding to a nuclear glucocorticoid receptor. [GOC:bf]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
transmembrane transporter binding	molecular function	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
protein heterodimerization activity	molecular function	Binding to a nonidentical protein to form a heterodimer. [GOC:ai]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
intercalated disc	cellular component	A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. [GOC:mtg_muscle, PMID:11732910]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]
cerebellar granule cell to Purkinje cell synapse	cellular component	A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum. [GOC:aruk, GOC:bc, PMID:12427822]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 14 target(s):

Target	Category	Definition
regulation of sodium ion transport	biological process	Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:dph]
glucocorticoid catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]
intracellular protein transport	biological process	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. [GOC:mah]
substantia nigra development	biological process	The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420]
intracellular glucocorticoid receptor signaling pathway	biological process	The series of molecular signals initiated by glucocorticoid binding to its nuclear receptor inside the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah]
regulation of neuron differentiation	biological process	Any process that modulates the frequency, rate or extent of neuron differentiation. [GOC:go_curators]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
regulation of synaptic plasticity	biological process	A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:dph, GOC:jid, GOC:tb, PMID:11891290]
negative regulation of dendrite morphogenesis	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]
membrane depolarization during action potential	biological process	The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
presynaptic modulation of chemical synaptic transmission	biological process	Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. [GOC:dos]
regulation of sodium ion transmembrane transporter activity	biological process	Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. [GOC:obol]
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
protein localization	biological process	Any process in which a protein is transported to, or maintained in, a specific location. [GOC:ai]