Compounds > propyl pyrazinoate
Page last updated: 2024-11-06

propyl pyrazinoate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Propyl pyrazinoate is a heterocyclic compound that exhibits significant biological activity. It is a derivative of pyrazine, a six-membered aromatic ring containing two nitrogen atoms. The compound has been studied for its potential as a anti-inflammatory, analgesic, and anticonvulsant agent. It is also known to possess antioxidant and neuroprotective properties. Research suggests that propyl pyrazinoate may exert its effects through various mechanisms, including modulation of inflammatory pathways, inhibition of oxidative stress, and interaction with neurotransmitter receptors. The synthesis of propyl pyrazinoate typically involves the reaction of pyrazine carboxylic acid with propanol in the presence of a suitable catalyst. Further research is ongoing to explore its therapeutic potential and optimize its pharmacological properties.'

Cross-References

ID SourceID
PubMed CID72507
CHEMBL ID19792
SCHEMBL ID8408307
MeSH IDM0252198

Synonyms (14)

Synonym
propyl pyrazinoate
brn 0777399
pyrazinecarboxylic acid, propyl ester
73763-87-8
propyl pyrazine-2-carboxylate
n-propyl pyrazinoate
CHEMBL19792
n-propyl-pyrazinoate
pyrazine-2-carboxylic acid propyl ester
5-25-04-00177 (beilstein handbook reference)
AKOS008948356
DTXSID50224118
AQMXNGDQEPGTRM-UHFFFAOYSA-N
SCHEMBL8408307
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID143430In vitro activity against Mycobacterium strain SMA (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143997In vitro activity against Mycobacterium. tuberculosis (strain type-ATCC 27289).at pH 6.61992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143291In vitro activity against Mycobacterium strain DOU (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143416In vitro activity against Mycobacterium. tuberculosis (strain type-H37Rv) at pH 6.61992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID144281In vitro activity against Mycobacterium. kansasii (strain type-SWK).at pH 6.61992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143275In vitro activity against Mycobacterium strain ATCC 35828 (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID278996Antimicrobial activity against Mycobacterium tuberculosis at pH 6.8 by broth microdilution test2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.
AID406203Inhibition of Mycobacterium tuberculosis fatty acid synthase 1 expressed in Mycobacterium smegmatis mc2 2700 assessed as [2-14C]]malonyl-CoA incorporation into fatty acid at 3000 uM2007Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.
AID143268In vitro activity against Mycobacterium. tuberculosis (strain type-ATCC 35828)at pH 6.61992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143279In vitro activity against Mycobacterium strain BUR (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143277In vitro activity against Mycobacterium strain BAK (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143281In vitro activity against Mycobacterium. tuberculosis (strain type-BUR)at pH 5.81992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143267In vitro activity against Mycobacterium. tuberculosis (strain type-ATCC 35828)at pH 5.81992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143998In vitro activity against Mycobacterium. tuberculosis (strain type-ATCC 27289).at pH 5.81992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143410In vitro activity against Mycobacterium strain GLA (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143287In vitro activity against Mycobacterium strain CES (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID406204Inhibition of Mycobacterium tuberculosis fatty acid synthase 1 expressed in Mycobacterium smegmatis mc2 2700 assessed as [2-14C]]malonyl-CoA incorporation into fatty acid at 6000 uM2007Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.
AID144166In vitro activity against Mycobacterium strain SWK (Mycobacterium kansasii)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID278995Antimicrobial activity against Mycobacterium tuberculosis at pH 6 by broth microdilution test2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.
AID144164In vitro activity against Mycobacterium strain SCH (Mycobacterium kansasii)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143289In vitro activity against Mycobacterium strain DOL (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143424In vitro activity against Mycobacterium strain ING (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143428In vitro activity against Mycobacterium strain MCQ (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID279002Inhibition of fatty acid synthase 1 in Mycobacterium tuberculosis assessed as incorporation of [1-14C]acetate in C16 biosynthesis at 800 ug/ml2007Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.
AID406066Inhibition of Mycobacterium tuberculosis fatty acid synthase 1 expressed in Mycobacterium smegmatis mc2 2700 assessed as NADPH oxidation at 100 uM of NADPH by spectrophotometry2007Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.
AID144280In vitro activity against Mycobacterium. kansasii (strain type-SWK).at pH 5.81992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143415In vitro activity against Mycobacterium. tuberculosis (strain type-H37Rv) at pH 5.81992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143426In vitro activity against Mycobacterium strain LEL (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
AID143408In vitro activity against Mycobacterium strain DUB (Mycobacterium tuberculosis)1992Journal of medicinal chemistry, Apr-03, Volume: 35, Issue:7
Antimycobacterial activity of a series of pyrazinoic acid esters.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
beta-alanine
[no description available]		2.110amino acid zwitterion;
beta-amino acid		agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter
niacinamide
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.		2.110pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
niacin
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.		1.9810pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
pyrazinamide
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.		8.2860monocarboxylic acid amide;
N-acylammonia;
pyrazines		antitubercular agent;
prodrug
pyrazinoic acid
pyrazinoic acid: active metabolite of pyrazinamide; structure. pyrazine-2-carboxylic acid : The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.		3.2860pyrazinecarboxylic acidantitubercular agent;
drug metabolite
benzamide
benzamide : An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.		2.0310benzamides
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.0310carbohydrazideantitubercular agent;
drug allergen
pantothenic acid
Pantothenic Acid: A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.. pantothenic acid : A member of the class of pantothenic acids that is an amide formed from pantoic acid and beta-alanine.. vitamin B5 : Any member of a group of vitamers that belong to the chemical structural class called pantothenic acids that exhibit biological activity against vitamin B5 deficiency. Deficiency of vitamin B5 is rare due to its widespread distribution in whole grain cereals, legumes and meat. Symptoms associated with vitamin B5 deficiency are difficult to asses since they are subtle and resemble those of other B vitamin deficiencies. The vitamers include (R)-pantothenic acid and its ionized and salt forms.. (R)-pantothenate : A pantothenate that is the conjugate base of (R)-pantothenic acid, obtained by deprotonation of the carboxy group.. (R)-pantothenic acid : A pantothenic acid having R-configuration.		2.110pantothenic acid;
vitamin B5		antidote to curare poisoning;
geroprotector;
human blood serum metabolite
ethambutol
Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.		2.0310ethanolamines;
ethylenediamine derivative		antitubercular agent;
environmental contaminant;
xenobiotic
5-chloropyrazinamide
[no description available]		2.7430
pantetheine
Pantetheine: An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.. pantetheine : An amide obtained by formal condensation of the carboxy group of pantothenic acid and the amino group of cysteamine.		2.110pantetheines;
thiol		human metabolite;
metabolite;
mouse metabolite
cerulenin
Cerulenin: An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.. cerulenin : An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.		2.0310epoxide;
monocarboxylic acid amide		antifungal agent;
antiinfective agent;
antilipemic drug;
antimetabolite;
antimicrobial agent;
fatty acid synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Koch's Disease
[description not available]		02.0310
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.0310