Compounds > o,o-diethyl dithiophosphate
Page last updated: 2024-11-05

o,o-diethyl dithiophosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

O,O-diethyl dithiophosphate: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9274
CHEMBL ID1886492
CHEBI ID189749
SCHEMBL ID268312
MeSH IDM0164322

Synonyms (78)

Synonym
nsc171184
o,o-diethyl-s-hydrogen phosphorodithioate
o,o-diethyl dithiophosphoric acid
o,o-diethyldithiophosphoric acid
wln: shps & o2 & o2
diethyl dithiophosphate
o,o-diethyl hydrogen phosphorodithioate
o,o-diethyl phosphorodithioate
nsc-171184
kyselina o,o-diethyldithiofosforecna
298-06-6
diethyl phosphorodithioic acid
o,o-diethyl phosphorodithioic acid
o,o-diethyl dithiophosphate
o,o-diethyldithiophosphate
diethyl phosphorodithioate
o,o'-diethyl dithiophosphate
dithiophosphoric acid,o-diethyl ester
o,o-diethylphosphorodithioic acid
phosphonodithioic acid,o-diethyl ester
o,o'-diethyl hydrogen dithiophosphate
phosphorodithioic acid, o,o-diethyl ester
o,o-diethyl hydrogen dithiophosphate
brn 0507407
o,o-diethyl dithiophosphoric acid ester
di-o-ethyl dithiophosphate
o,o-diethyl thiolothionophosphate
kyselina o,o-diethyldithiofosforecna [czech]
phosphordithioic acid, o,o-diethyl ester
einecs 206-055-9
hsdb 5558
nsc 171184
dithiophosphoric acid, o,o-diethyl ester
o,o'-diethyl dithiophosphate, technical grade, 90%
NCGC00163992-01
NCIOPEN2_007003
52857-42-8
FT-0694951
dithiophosphoric acid o,o'-diethyl ester
D1543
diethylphosphorodithioate
diethoxy-sulanyl-sulanylidene-lambda5-phosphane
CHEBI:189749
tox21_301493
NCGC00255332-01
cas-298-06-6
dtxcid007133
dtxsid6027133 ,
A820058
phosphorodithioic acid, diethyl ester
unii-02c5xr639p
ec 206-055-9
02c5xr639p ,
4-01-00-01354 (beilstein handbook reference)
FT-0649368
STL373474
AKOS015901212
diethyl ester of phosphorodithioic acid
o,o-diethyl phosphorodithioate [hsdb]
SCHEMBL268312
BBL027484
dithiophosphoric acid o,o-diethyl ester
dithiophosphoric acid-o,o-diethylester
o,o-diethyl s-hydrogen phosphorodithioate
(eto)2p(s)sh
(c2h5o)2pssh
diethyldithiophosphoric acid
phosphorodithioic acid, o,o'-diethyl ester
o,o-diethyl hydrogen dithiophosphate #
o,o-diethylphosphorodithioate
phosphorothiothionic acid, o,o-diethyl ester
CHEMBL1886492
dithiophosphoricacido,o-diethylester
diethyl dithiophosphoric acid
J-017651
Q309536
diethoxy-sulfanyl-sulfanylidene-lambda5-phosphane
CS-0141956
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
organic thiophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency33.42020.007215.758889.3584AID1224835
acetylcholinesteraseHomo sapiens (human)Potency29.41170.002541.796015,848.9004AID1347395; AID1347398
AR proteinHomo sapiens (human)Potency51.62600.000221.22318,912.5098AID743036
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.02240.000214.376460.0339AID588532
pregnane X nuclear receptorHomo sapiens (human)Potency28.78430.005428.02631,258.9301AID1346982
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's3 (33.33)18.2507
2000's4 (44.44)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.39 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.69 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
diethyl phosphate
diethyl phosphate: RN given refers to parent cpd. diethyl hydrogen phosphate : A dialkyl phosphate having ethyl as the alkyl group.		1.9810dialkyl phosphatehuman xenobiotic metabolite;
mouse metabolite
o,o-diethyl phosphorothionate
O,O-diethyl phosphorothionate: metabolite of organothiophosphorous insecticides; structure given in first source. O,O-diethyl hydrogen thiophosphate : An organic thiophosphate that is the diethyl ester of phosphorothioic O,O,O-acid.		2.420organic thiophosphatehuman xenobiotic metabolite;
mouse metabolite
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.0310alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
pyrithione
pyrithione: split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure. pyrithione : A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent.		1.9710monohydroxypyridine;
pyridinethione		ionophore
phosalone
phosalone: structure. phosalone : A member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide.		1.98101,3-benzoxazoles;
carbamate ester;
organochlorine insecticide;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		2.0510ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
o-isopropyl xanthate
O-isopropyl xanthate: structure given in first source		1.9710thiocarbonyl compound
ethylxanthate
ethylxanthate: structure in first source		1.9710
ditiocarb
Ditiocarb: A chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.. diethyldithiocarbamic acid : A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur.		1.9710dithiocarbamic acidschelator;
copper chelator
mercury
Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.		1.9710elemental mercury;
zinc group element atom		neurotoxin
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		2.0510cadmium molecular entity;
zinc group element atom
o,o-dimethyl phosphorothionate
O,O-dimethyl phosphorothionate: metabolite of phosmet; RN given refers to parent cpd		2.0110organic thiophosphate
dimethyldithiocarbamate
Dimethyldithiocarbamate: A chemical that acts as a dopamine beta-hydroxylase inhibitor. Its salts are agricultural fungicides. It is inferior to diethyldithiocarbamate as a chelating agent.. dimethyldithiocarbamate : A member of the class of dithiocarbamate anions resulting from the removal of the proton from the dithiocarbamic acid moiety of dimethyldithiocarbamic acid. The major species at pH 7.3.		1.9710dithiocarbamate anions
o,o-dimethyl phosphorodithioate
O,O-dimethyl phosphorodithioate: metabolite of phosmet; RN given refers to parent cpd		2.420
maleamic acid
maleamic acid: structure. maleamic acid : A dicarboxylic acid monoamide of maleamic acid.		1.9810alpha,beta-unsaturated monocarboxylic acid;
dicarboxylic acid monoamide		bacterial xenobiotic metabolite;
Escherichia coli metabolite
selenium
Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.		2.2110chalcogen;
nonmetal atom		micronutrient
aluminum oxide
Aluminum Oxide: An oxide of aluminum, occurring in nature as various minerals such as bauxite, corundum, etc. It is used as an adsorbent, desiccating agent, and catalyst, and in the manufacture of dental cements and refractories.		2.0210
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0110