menaquinol 6

Description

menaquinol 6: a short chain analog of vitamin K2; physiological electron donor [MeSH]

menaquinol-6 : A menaquinol whose structure comprises a 2-methylbenzohydroquinone nucleus and a side chain of six isoprenoid units. [CHeBI]

Cross-References

ID Source	ID
PubMed CID	6441040
CHEBI ID	84536
MeSH ID	M0182489

Synonyms (11)

Synonym
menaquinol-6
menaquinol(6)
mkh2-6
menaquinol 6
2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaenyl]-3-methylnaphthalene-1,4-diol
mqh2-6
39776-48-2
1,4-naphthalenediol, 2-(3,7,11,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaenyl)-3-methyl-
2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methylnaphthalene-1,4-diol
CHEBI:84536
Q27157840

Roles (1)

Role	Description
electron donor	A molecular entity that can transfer an electron to another molecular entity.

Drug Classes (1)

Class	Description
menaquinol	Any polyprenylhydroquinone having a polyprenyl moiety at position 2 and a methyl group at position 3..

Pathways (2)

menaquinol 6 is involved in 2 pathway(s), involving a total of 4 unique proteins and 29 unique compounds

Pathway	Proteins	Compounds
superpathway of menaquinol-6 biosynthesis I	3	24
menaquinol-6 biosynthesis	1	5

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (33.33)	18.2507
2000's	8 (53.33)	29.6817
2010's	2 (13.33)	24.3611
2020's	0 (0.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
menahydroquinone-4	0	menaquinol		0	0		low	0	0	0	0	0	0

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
hydrogen	0	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite	0	0		low	0	0	0	0	0	0
2-hydroxypyrimidine	0	hydroxypyrimidine	electron donor; Lewis base	0	0		low	0	0	0	0	0	0

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's	2010's
nitrates	1	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species		2003	2003	21.0	low	0	1	0
pentachlorophenol	2	aromatic fungicide; chlorophenol; organochlorine pesticide; pentachlorobenzenes	human xenobiotic metabolite	1999	2005	22.0	low	1	1	0
thiosulfates	1	divalent inorganic anion; sulfur oxide; sulfur oxoanion	human metabolite	2012	2012	12.0	low	0	0	1
succinic acid	1	alpha,omega-dicarboxylic acid; C4-dicarboxylic acid	anti-ulcer drug; fundamental metabolite; micronutrient; nutraceutical; radiation protective agent	1999	1999	25.0	low	1	0	0
2-(n-heptyl)-4-hydroxyquinoline n-oxide	3	monohydroxyquinoline		1999	2005	21.7	low	1	2	0
diethyl pyrocarbonate	1	acyclic carboxylic anhydride		1998	1998	26.0	low	1	0	0
glutamine	1	amino acid zwitterion; glutamine family amino acid; glutamine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	2000	2000	24.0	low	1	0	0
lysine	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite	2005	2005	19.0	low	0	1	0
tyrosine	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical	2003	2003	21.0	low	0	1	0
histidine	2	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	2003	2005	20.0	low	0	2	0
arginine	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical	2003	2003	21.0	low	0	1	0
2-naphthol	15	naphthol	antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger	1990	2019	21.0	high	6	7	2
menadiol	1	methylnaphthalenes; naphthalenediols; naphthohydroquinone		2003	2003	21.0	low	0	1	0
glutamic acid	2	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical	2000	2004	22.0	low	1	1	0
glycidyl nitrate	1			2019	2019	5.0	low	0	0	1
diaminopimelic acid	1	2,6-diaminopimelic acid; amino acid zwitterion	Escherichia coli metabolite	2019	2019	5.0	low	0	0	1
fumaric acid	2	butenedioic acid	food acidity regulator; fundamental metabolite; geroprotector	1990	1999	29.5	low	2	0	0
stigmatellin	1	aromatic ether; chromones; olefinic compound; phenols	bacterial metabolite; quinol oxidation site inhibitor	2003	2003	21.0	low	0	1	0
vitamin k semiquinone radical	1			2003	2003	21.0	low	0	1	0
fumarates	2	butenedioate; C4-dicarboxylate	human metabolite; metabolite; Saccharomyces cerevisiae metabolite	1990	1999	29.5	low	2	0	0
ubiquinol	2	polyprenylhydroquinone; ubiquinol	biomarker; metabolite	1998	2005	22.5	low	1	1	0
cytochrome c-t	1			2008	2008	16.0	low	0	1	0
ubiquinone	3			1998	2005	23.3	low	2	1	0
chiniofon	3			1999	2005	21.7	low	1	2	0
glycolipids	1			2019	2019	5.0	low	0	0	1
heme	4			2001	2008	19.8	low	0	4	0

Condition	Indicated	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020

menaquinol 6

Description

Cross-References

Synonyms (11)

Roles (1)

Drug Classes (1)

Pathways (2)

Research

Studies (15)

Study Types

Related Drugs (29)

Drugs in this Class (1)

Drugs with this Function (2)

Drugs Researched Together (26)

Related Conditions (0)