Compounds > felinine
Page last updated: 2024-12-08

felinine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

felinine: a sulfur-containing amino acid; a major component in the urine of domestic cat [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

felinine : A cysteine thioether that is the S-(4-hydroxy-2-methylbutan-2-yl) derivative of L-cysteine. It is a major component of the urine of the domestic cat. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID164607
CHEBI ID39390
SCHEMBL ID991435
MeSH IDM0258121

Synonyms (22)

Synonym
s-(3-hydroxy-1,1-dimethylpropyl)-l-cysteine
CHEBI:39390
(-)-felinine
471-09-0
(2r)-2-amino-3-[(4-hydroxy-2-methylbutan-2-yl)sulfanyl]propanoic acid
felinine
s-(4-hydroxy-2-methylbutan-2-yl)-l-cysteine
(2r)-2-amino-3-(4-hydroxy-2-methylbutan-2-yl)sulfanylpropanoic acid
l-cysteine, s-(3-hydroxy-1,1-dimethylpropyl)-
2-amino-7-hydroxy-5,5-dimethyl-4-thiaheptanoic acid
8v49j0abl5 ,
unii-8v49j0abl5
alanine, 3-((3-hydroxy-1,1-dimethylpropyl)thio)-, l-
felinine [mi]
l-felinine
SCHEMBL991435
DTXSID10197036
AKOS030240638
(r)-2-amino-3-(4-hydroxy-2-methylbutan-2-ylthio)propanoic acid
l-2-amino-7-hydroxy-5,5-dimethyl-4-thiaheptanoic acid
Q1053817
(r)-2-amino-3-((4-hydroxy-2-methylbutan-2-yl)thio)propanoic acid

Research Excerpts

Overview

Felinine is a unique sulfur-containing amino acid found in the urine of domestic cats and select members of the Felidae family.

ExcerptReferenceRelevance
"Felinine is a branched-chain sulfur amino acid present in the urine of certain Felidae, including domestic cats. "( Urinary felinine excretion in intact male cats is increased by dietary cystine.
Hendriks, WH; Hugh Morton, R; Rogers, QR; Rutherfurd-Markwick, KJ; Weidgraaf, K, 2008)		2.22
"Felinine is a unique sulfur-containing amino acid found in the urine of domestic cats and select members of the Felidae family. "( Isolation and characterization of a felinine-containing peptide from the blood of the domestic cat (Felis catus).
Hendriks, WH; Moughan, PJ; Rutherfurd, KJ; Rutherfurd, SM, 2002)		2.03

Dosage Studied

ExcerptRelevanceReference
" In addition, the benefit of metabonomics as an open approach as compared to targeted methods was demonstrated by the identification of an unknown molecule in the urine of rats dosed with zoledronate."( Application of metabonomics in a comparative profiling study reveals N-acetylfelinine excretion as a biomarker for inhibition of the farnesyl pathway by bisphosphonates.
Binder, M; Dieterle, F; Ross, A; Schlotterbeck, G; Senn, H; Suter, L, 2007)		0.57
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
pheromoneA semiochemical used in olfactory communication between organisms of the same species eliciting a change in sexual or social behaviour.
mammalian metaboliteAny animal metabolite produced during a metabolic reaction in mammals.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
L-cysteine thioetherAny L-cysteine derivative obtained by conversion of the thiol group into a sulfide.
non-proteinogenic L-alpha-amino acidAny L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
S-alkyl-L-cysteine zwitterionAn S-substituted L-cysteine zwitterion in which the S-substituent can be any alkyl group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis08
felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis18

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.56)18.7374
1990's3 (16.67)18.2507
2000's9 (50.00)29.6817
2010's4 (22.22)24.3611
2020's1 (5.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.72 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index39.34 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (31.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (94.44%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-butanol
1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1.. butan-1-ol : A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.		2.0210alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol		human metabolite;
mouse metabolite;
protic solvent
creatine
[no description available]		2.0310glycine derivative;
guanidines;
zwitterion		geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical
taurine
[no description available]		2.0310amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.0310isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		2.0210amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		7.4220aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
n-pentanol
n-pentanol: RN given refers to parent cpd. pentan-1-ol : A short-chain primary fatty alcohol that is pentane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It has been isolated from Melicope ptelefolia.		2.9740pentanol;
short-chain primary fatty alcohol		human metabolite;
plant metabolite
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		2.0410arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
biuret
Biuret: Used as feed supplement for sheep and cattle since it is a good non-protein nitrogen source. In strongly alkaline solution biuret gives a violet color with copper sulfate.. biuret : A member of the class of condensed ureas that is the compound formed by the condensation of two molecules of urea; the parent compound of the biuret group of compounds. Used as a non-protein nitrogen source in ruminant feed.		2.0310condensed ureas
ibandronic acid
Ibandronic Acid: Aminobisphosphonate that is a potent inhibitor of BONE RESORPTION. It is used in the treatment of HYPERCALCEMIA associated with malignancy, for the prevention of fracture and bone complications in patients with breast cancer and bone metastases, and for the treatment and prevention of POSTMENOPAUSAL OSTEOPOROSIS.		2.0310
zoledronic acid
Zoledronic Acid: An imidobisphosphonate inhibitor of BONE RESORPTION that is used for the treatment of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.. zoledronic acid : An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.		2.03101,1-bis(phosphonic acid);
imidazoles		bone density conservation agent
thiourea
Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.		2.0310one-carbon compound;
thioureas;
ureas		antioxidant;
chromophore
cystine
[no description available]		7.4320
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		10.37180cysteiniumfundamental metabolite
2-amino-5-carboxy-6-methyl-4-thiaheptanoic acid
2-amino-5-carboxy-6-methyl-4-thiaheptanoic acid: a sulfur-containing amino acid; a major component in the urine of domestic cat		2.0210
gamma-glutamylfelinylglycine
gamma-glutamylfelinylglycine: structure in first source		2.7330oligopeptide
ConditionIndicatedRelationship StrengthStudiesTrials
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.0810
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0310
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9910
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		01.9910