Compounds > dibenzyl trisulfide
Page last updated: 2024-12-07

dibenzyl trisulfide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dibenzyl trisulfide: structure in first source; an antiproliferative agent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122842
CHEMBL ID378770
SCHEMBL ID2803113
MeSH IDM0479710

Synonyms (26)

Synonym
nsc709944
NCI60_038710
6493-73-8
(benzyltrisulfanyl)methylbenzene
trisulfane, bis(phenylmethyl)-
nsc-709944
benzyl trisulfide
CHEMBL378770
dibenzyl trisulfide
FT-0663069
dibenzyltrisulfane
unii-c8u5bef9rn
c8u5bef9rn ,
trisulfide, bis(phenylmethyl)
AKOS015913250
bis(phenylmethyl)trisulfide
benzyltrisulfide
SCHEMBL2803113
1,3-dibenzyltrisulfane #
UXDMWYANCHMSJX-UHFFFAOYSA-N
DTXSID90215247
1,3-dibenzyltrisulfane
A854560
DTS ,
dibenzyl trisulphide
guinea hen weed active ingredient

Research Excerpts

Overview

Dibenzyl trisulfide (DTS) is a natural compound with potential cancer-preventive properties. DTS occurs in Petiveria alliacea L., an ethnomedicinal plant native to the Americas.

ExcerptReferenceRelevance
"Dibenzyl trisulfide (DTS) is a natural compound with potential cancer-preventive properties occurring in Petiveria alliacea L., an ethnomedicinal plant native to the Americas. "( In Silico Design and SAR Study of Dibenzyl Trisulfide Analogues for Improved CYP1A1 Inhibition.
Clarke, N; Irvine, W, 2022)		2.44

Effects

ExcerptReferenceRelevance
"Dibenzyl trisulfide (DTS) has been reported to have cytotoxic and anti-inflammatory effects. "( In vitro effect of dibenzyl trisulfide on the p50 of the oxygen haemoglobin dissociation curve.
Marsh, DT; McKoy, MG; Pepple, DJ, 2020)		2.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID270898Antitumor activity against human MCF7 cell line by RTCES assay2006Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
Synthesis and anti-tumor evaluation of new trisulfide derivatives.
AID270900Antitumor activity against human HeLa cell line by RTCES assay2006Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
Synthesis and anti-tumor evaluation of new trisulfide derivatives.
AID270896Antitumor activity against human HT1080 cell line by RTCES assay2006Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
Synthesis and anti-tumor evaluation of new trisulfide derivatives.
AID270895Antitumor activity against human OVACR4 cell line by RTCES assay2006Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
Synthesis and anti-tumor evaluation of new trisulfide derivatives.
AID270901Antitumor activity against human HepG2 cell line by RTCES assay2006Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
Synthesis and anti-tumor evaluation of new trisulfide derivatives.
AID270899Antitumor activity against human M231 cell line by RTCES assay2006Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
Synthesis and anti-tumor evaluation of new trisulfide derivatives.
AID270897Antitumor activity against human H460 cell line by RTCES assay2006Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
Synthesis and anti-tumor evaluation of new trisulfide derivatives.
AID270894Antitumor activity against human A2780 cell line by RTCES assay2006Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
Synthesis and anti-tumor evaluation of new trisulfide derivatives.
AID270893Antitumor activity against human jurkat cell line by MTT assay2006Bioorganic & medicinal chemistry letters, Sep-15, Volume: 16, Issue:18
Synthesis and anti-tumor evaluation of new trisulfide derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (35.71)29.6817
2010's5 (35.71)24.3611
2020's4 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.83

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.83 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.64 (4.65)
Search Engine Demand Index19.78 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.83)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.		2.3110ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
fluorobenzenes
Fluorobenzenes: Derivatives of BENZENE that contain FLUORINE.. monofluorobenzene : The simplest member of the class of monofluorobenzenes that is benzene carrying a single fluoro substituent.. fluorobenzenes : Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group.		2.0510monofluorobenzenesNMR chemical shift reference compound
3,4,5,3',4'-pentachlorobiphenyl
3,3',4,4',5-pentachlorobiphenyl : A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.		2.3110pentachlorobiphenyl;
trichlorobenzene
diallyl tetrasulfide
[no description available]		2.1510organosulfur compound
matairesinol
matairesinol: lignan that is a central precursor in plants in the biosynthesis of numerous lignans (coordinate with specific); RN refers to (3R-trans)-isomer. (-)-matairesinol : A lignan that is gamma-butyrolactone in which the 3 and 4 positions are substituted by 4-hydroxy-3-methoxybenzyl groups (the 3R,4R-diastereomer).		2.0410gamma-lactone;
lignan;
polyphenol		angiogenesis inhibitor;
anti-asthmatic agent;
phytoestrogen;
plant metabolite
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		2.0410
fluorapacin
fluorapacin: has antineoplastic activity; structure in first source		2.4420
ConditionIndicatedRelationship StrengthStudiesTrials
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available]		02.4110
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.		02.4110
Benign Neoplasms
[description not available]		02.5820
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.5820
Colorectal Cancer
[description not available]		02.1510
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.1510
Chromosome-Defective Micronuclei
[description not available]		02.0410
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.		02.0510
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		02.0510
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.0210