Compounds > deltonin
Page last updated: 2024-11-08

deltonin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID441884
CHEBI ID4389
MeSH IDM0066281

Synonyms (17)

Synonym
55659-75-1
deltonin
beta-d-glucopyranoside, (3beta,25r)-spirost-5-en-3-yl o-6-deoxy-alpha-l-mannopyranosyl-(1-2)-o-(beta-d-glucopyranosyl-(1-4))-
39y54r152i ,
(3beta,25r)-spirost-5-en-3-yl o-6-deoxy-alpha-l-mannopyranosyl-(1-2)-o-(beta-d-glucopyranosyl-(1-4))-beta-d-glucopyranoside
unii-39y54r152i
chebi:4389 ,
.beta.-d-glucopyranoside, (3.beta.,25r)-spirost-5-en-3-yl o-6-deoxy-.alpha.-l-mannopyranosyl-(1->2)-o-(.beta.-d-glucopyranosyl-(1->4))-
3-o-.beta.-d-glucopyranosyl(1->4)-(.alpha.-l-rhamnopyranosyl(1->2))-.beta.-d-glucopyranoside-diosgenin
Q27106367
CS-0019612
HY-N2283
(2s,3r,4r,5r,6s)-2-[(2r,3r,4s,5s,6r)-4-hydroxy-6-(hydroxymethyl)-2-[(1s,2s,4s,5'r,6r,7s,8r,9s,12s,13r,16s)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxy-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxy
MS-31641
DTXSID701319158
2-[4-hydroxy-6-(hydroxymethyl)-2-(5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl)oxy-5-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
AKOS040756438

Research Excerpts

Overview

Deltonin is a naturally occurring spirostanol glycoside from Dioscorea zingiberensis C.H. It could suppress tumor growth through suppressing angiogenesis. The mechanisms have not been directly elucidated yet.

ExcerptReferenceRelevance
"Deltonin is a naturally occurring spirostanol glycoside from Dioscorea zingiberensis C.H. "( Determination of deltonin in rat plasma by using HPLC-MS/MS and the application of this method in pharmacokinetic studies.
Chen, Q; Du, D; Gao, B; He, Y; Huang, B; Huang, W; Sun, A; Xin, G; Xing, Z; Zhang, R, 2013)		2.17
"Deltonin is a steroidal saponin which could suppress tumor growth through suppressing angiogenesis, but the mechanisms have not been directly elucidated yet. "( Deltonin inhibits angiogenesis by regulating VEGFR2 and subsequent signaling pathways in endothelial cells.
Hu, X; Jiang, L; Qing, Y; Tong, Q; Wu, X; Zhao, Q, 2015)		3.3
"Deltonin is an active component purified from Dioscorea zingiberensis WRIGHT (DZW), and has shown anticancer effects. "( Deltonin isolated from Dioscorea zingiberensis inhibits cancer cell growth through inducing mitochondrial apoptosis and suppressing Akt and mitogen activated protein kinase signals.
He, Y; Huang, W; Li, Y; Qing, Y; Shu, D; Tong, Q; Wei, Y; Wu, X; Xing, Z; Zhao, Y, 2011)		3.25

Treatment

Deltonin treatment caused a noticeable apoptosis in tumor tissue. It associated with increased levels of Bax, activated caspase-3, caspases-9, and cleaved poly (ADPribose) polymerase.

ExcerptReferenceRelevance
"The deltonin treatment caused a noticeable apoptosis in tumor tissue, which associated with increased levels of Bax, activated caspase-3, caspase-9, and cleaved poly (ADPribose) polymerase, decreased pro-caspase-8, pro-caspase-9, Bcl-2 expression levels and extracellular signal-regulated kinase-1/2 activity; and dose-dependently inhibit angiogenesis."( Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis.
He, Y; Huang, W; Li, Y; Qing, Y; Shu, D; Tong, QY; Wang, ZL; Wei, YQ; Wu, XH; Xing, ZH; Xu, C; Zhang, SY; Zhao, YL, 2011)		2.29
"Deltonin treatment also resulted in Bax upregulation, Bcl-2 downregulation, activation of caspase‑3 and ‑8 and poly (ADP ribose) polymerase cleavage."( Deltonin induces apoptosis in MDA‑MB‑231 human breast cancer cells via reactive oxygen species‑mediated mitochondrial dysfunction and ERK/AKT signaling pathways.
Chen, Q; He, Y; Huang, W; Tong, Q; Wu, X; Zhang, S, 2013)		2.55

Pharmacokinetics

ExcerptReferenceRelevance
" To investigate the pharmacokinetic profiles of deltonin, a rapid, sensitive, and simplified high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay was developed and validated for the determination of deltonin in rat plasma."( Determination of deltonin in rat plasma by using HPLC-MS/MS and the application of this method in pharmacokinetic studies.
Chen, Q; Du, D; Gao, B; He, Y; Huang, B; Huang, W; Sun, A; Xin, G; Xing, Z; Zhang, R, 2013)		0.99
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID717737Cytotoxicity against mouse C26 cells after 48 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
Synthesis, characterization and biological studies of diosgenyl analogues.
AID1454229Cytotoxicity against human NCI-H460 cells incubated for 24 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
Novel phenanthrene and isocoumarin from the rhizomes of Dioscorea nipponica Makino subsp. rosthornii (Prain et Burkill) C. T. Ting (Dioscoreaceae).
AID717736Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
Synthesis, characterization and biological studies of diosgenyl analogues.
AID717738Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
Synthesis, characterization and biological studies of diosgenyl analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's9 (81.82)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.73 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index5.14 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		2.0710benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
diethylhexyl phthalate
Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.		2.1510diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser
diosgenin
[no description available]		3.32603beta-sterol;
hexacyclic triterpenoid;
sapogenin;
spiroketal		antineoplastic agent;
antiviral agent;
apoptosis inducer;
metabolite
dioscin
[no description available]		2.9840hexacyclic triterpenoid;
spiroketal;
spirostanyl glycoside;
trisaccharide derivative		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 1.14.18.1 (tyrosinase) inhibitor;
hepatoprotective agent;
metabolite
furostanol i
furostanol I: from Dioscorea deltoidea; intermediate in in vivo diosgenin biosynthesis; structure given in first source. protodioscin : A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of 26-(beta-D-glucopyranosyloxy)-3beta,22-dihydroxyfurost-5-ene via a glycosidic linkage. Found in several plant species including yams, asparagus and funugreek.		2.0810beta-D-glucoside;
cyclic hemiketal;
pentacyclic triterpenoid;
steroid saponin;
trisaccharide derivative		metabolite
glycosides
[no description available]		2.0810
lyoniside
daucosterol : A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa.		2.1510beta-D-glucoside;
monosaccharide derivative;
steroid saponin		plant metabolite
beta-escin
[no description available]		2.9840
1,7-bis(4-hydroxyphenyl)hepta-4E-6E-dien-3-one
1,7-bis(4-hydroxyphenyl)hepta-4E-6E-dien-3-one : A diarylheptanoid that is 4E-6E-dien-3-one substituted by 4-hydroxyphenyl group at positions 1 and 7. It has been isolated from the rhizomes of Curcuma kwangsiensis.		2.1510diarylheptanoid;
enone;
phenols		plant metabolite
prosapogenin a
[no description available]		2.1510steroid saponin
gracillin
gracillin: spirostan glycoside from Tamus communis; RN given refers to (3beta,25R)-isomer		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Anasarca
[description not available]		02.0710
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.0710
Cancer of Lung
[description not available]		02.1510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.1510
Cancer of Colon
[description not available]		02.0610
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0610
Angiogenesis, Pathologic
[description not available]		02.0610
Colonic Neoplasms
Tumors or cancer of the COLON.		02.0610
Benign Neoplasms
[description not available]		02.0610
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0610
Breast Cancer
[description not available]		07.0810
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0810