deltonin and Edema

deltonin has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for deltonin and Edema

Article	Year
Synthesis, characterization and biological studies of diosgenyl analogues. Bioorganic & medicinal chemistry letters, 2012, Dec-15, Volume: 22, Issue:24 A series of optical amino acid diosgenyl esters and diosgenyl salicylate conjugates were designed and synthesized to develop new anticancer and anti-inflammatory agents. The analogue 9c that contains an 6-aminohexanoic acid residue at C-3 of diosgenin exhibits higher potency against all three tumor cell lines with IC(50) values ranging from 4.7 μM in C26 cells to 14.6 μM in Hep G2 cells. In addition, seven of newly synthesized compounds significantly inhibit xylene-induced ear edema and exhibit comparable or better anti-inflammatory activities than those of diosgenin and aspirin. Furthermore, preliminary structure-activity relationship studies demonstrate that diosgenyl salicylate conjugates have stronger anti-inflammatory activities than amino acid diosgenyl esters. Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diosgenin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Edema; Hep G2 Cells; Humans; Molecular Structure; Rats; Structure-Activity Relationship; Xylenes	2012

Article

Year

Synthesis, characterization and biological studies of diosgenyl analogues.

Bioorganic & medicinal chemistry letters, 2012, Dec-15, Volume: 22, Issue:24

A series of optical amino acid diosgenyl esters and diosgenyl salicylate conjugates were designed and synthesized to develop new anticancer and anti-inflammatory agents. The analogue 9c that contains an 6-aminohexanoic acid residue at C-3 of diosgenin exhibits higher potency against all three tumor cell lines with IC(50) values ranging from 4.7 μM in C26 cells to 14.6 μM in Hep G2 cells. In addition, seven of newly synthesized compounds significantly inhibit xylene-induced ear edema and exhibit comparable or better anti-inflammatory activities than those of diosgenin and aspirin. Furthermore, preliminary structure-activity relationship studies demonstrate that diosgenyl salicylate conjugates have stronger anti-inflammatory activities than amino acid diosgenyl esters.

Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diosgenin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Edema; Hep G2 Cells; Humans; Molecular Structure; Rats; Structure-Activity Relationship; Xylenes

2012