Compounds > prosapogenin a
Page last updated: 2024-11-12

prosapogenin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID11061578
CHEMBL ID395415
CHEBI ID196988
MeSH IDM0316786

Synonyms (26)

Synonym
CHEMBL395415
prosapogenin a
(2s,3r,4r,5r,6s)-2-[(2r,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(1s,2s,4s,5'r,6r,7s,8r,9s,12s,13r,16s)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
CHEBI:196988
paris saponin v
progenin iii
unii-220ias5qo7
220ias5qo7 ,
lilioglycoside d
beta-glucopyranoside, (3beta,25r)-spirost-5-en-3-yl 2-o-(6-deoxy-alpha-l-mannopyranosyl)-
19057-67-1
saponin ta
AKOS030530339
mfcd16294846
HDXIQHTUNGFJIC-FOAHKCLGSA-N
prosapogenin d'1
ophiopogonin c'
17-deoxyparis vi
diosgenin 3-o-.alpha.-l-rhamnopyranosyl-(1->2)-.beta.-d-glucopyranoside
.beta.-d-glucopyranoside, (3.beta.,25r)-spirost-5-en-3-yl 2-o-(6-deoxy-.alpha.-l-mannopyranosyl)-
paris v
(2s,3r,4r,5r,6s)-2-(((2r,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((4s,5'r,6ar,6bs,8as,8br,9s,10r,11as,12as,12bs)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,
CS-0027934
MS-31243
(25r)-3beta-(2-o-alpha-l-rhamnopyranosyl-beta-d-glucopyranosyloxy)spirosta-5-ene
HY-N6940
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
steroid saponinAny saponin derived from a hydroxysteroid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (42)

Assay IDTitleYearJournalArticle
AID401956Antimicrobial activity against Enterobacter cloacae at 64 ug/mL by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID401963Growth inhibition of human NCI-H460 cells after 48 hrs2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID401706Antimicrobial activity against Cryptococcus neoformans ATCC 90112 by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID401958Antimicrobial activity against Neisseria gonorrhoeae at 64 ug/mL by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID323727Cell cycle arrest in human HL60 cells assessed as accumulation at G2/M phase at 10 uM after 16 hrs relative to control by flow cytometry2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID294375Cytotoxicity against human erythrocytes assessed as hemolytic activity after 60 mins2007Bioorganic & medicinal chemistry, Apr-01, Volume: 15, Issue:7
Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins.
AID1729699Cytotoxicity against HUVEC assessed as reduction in cell viability after 72 hrs by MTS assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.
AID1729696Cytotoxicity against human GSC3 cells assessed as reduction in cell viability after 72 hrs by MTS assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.
AID401954Antimicrobial activity against Enterococcus faecalis at 64 ug/mL by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID323721Cytotoxicity against human U937 cells after 72 hrs by MTT assay2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID323728Cell cycle arrest in human HL60 cells assessed as accumulation at G2/M phase at 30 uM after 16 hrs relative to control by flow cytometry2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID323731Effect on cell death in human HL60 cells assessed as cleavage of procaspase 3 at 10 uM after 6 hrs by Western blot analysis2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID401965Growth inhibition of human DU145 cells after 48 hrs2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID323726Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 30 uM after 16 hrs relative to control by flow cytometry2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID1729700Cytotoxicity against human T98G assessed as reduction in cell viability after 72 hrs by MTS assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.
AID401708Antimicrobial activity against Streptococcus pneumoniae ATCC 6303 by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID401960Growth inhibition of humanBxPC3 cells after 48 hrs2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID401962Growth inhibition of human SF268 cells after 48 hrs2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID1454229Cytotoxicity against human NCI-H460 cells incubated for 24 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
Novel phenanthrene and isocoumarin from the rhizomes of Dioscorea nipponica Makino subsp. rosthornii (Prain et Burkill) C. T. Ting (Dioscoreaceae).
AID323735Induction of apoptosis in human HL60 cells assessed as Bcl2 expression2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID401961Growth inhibition of human MCF7 cells after 48 hrs2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID1729698Cytotoxicity against human 293T cells assessed as reduction in cell viability after 72 hrs by MTS assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.
AID323737Effect on cell death in human HL60 cells assessed as cleavage of procaspase 9 at 10 uM after 6 hrs by Western blot analysis2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID323720Cytotoxicity against human HL60 cells after 72 hrs by MTT assay2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID323736Induction of apoptosis in human U937 cells assessed as Bcl2 expression2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID401952Antimicrobial activity against Micrococcus luteus presque Isle 456 at 64 ug/mL by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID323729Induction of apoptosis in human HL60 cells at 10 uM after 16 hrs by flow cytometry relative to control2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID323722Cytotoxicity against human SKMEL1 cells after 72 hrs by MTT assay2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID401955Antimicrobial activity against Escherichia coli at 64 ug/mL by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID401964Growth inhibition of human KM20L2 cells after 48 hrs2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID323723Cell cycle arrest in human HL60 cells assessed as accumulation at G0/G1 phase at 10 uM after 16 hrs relative to control by flow cytometry2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID323725Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 10 uM after 16 hrs relative to control by flow cytometry2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID333698Cytotoxicity against human HeLa cells after 72 hrs by MTT assay2004Journal of natural products, Dec, Volume: 67, Issue:12
Cytotoxic steroidal saponins from Polygonatum zanlanscianense.
AID1729701Cytotoxicity against human U-87 MG cells assessed as reduction in cell viability after 72 hrs by MTS assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.
AID401959Growth inhibition of mouse P388 cells after 48 hrs2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID401957Antimicrobial activity against Stenotrophomonas maltophilia at 64 ug/mL by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID1729697Cytotoxicity against human GSC18 cells assessed as reduction in cell viability after 72 hrs by MTS assay2021European journal of medicinal chemistry, Jan-15, Volume: 210Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A.
AID401707Antimicrobial activity against Candida albicans ATCC 90028 by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID323724Cell cycle arrest in human HL60 cells assessed as accumulation at G0/G1 phase at 30 uM after 16 hrs relative to control by flow cytometry2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID323732Effect on cell death in human U937 cells assessed as cleavage of procaspase 3 at 10 uM after 6 hrs by Western blot analysis2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
AID401953Antimicrobial activity against Staphylococcus aureus at 64 ug/mL by broth micro dilution assay2005Journal of natural products, May, Volume: 68, Issue:5
Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.
AID323733Induction of apoptosis in human HL60 cells assessed as increase in cytochrome c release from mitochondria at 10 uM after 6 hrs2008Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
Synthesis of novel spirostanic saponins and their cytotoxic activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.70

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.70 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.65 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.70)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
temozolomide
[no description available]		2.3110imidazotetrazine;
monocarboxylic acid amide;
triazene derivative		alkylating agent;
antineoplastic agent;
prodrug
diethylhexyl phthalate
Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.		2.1510diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.3110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
diosgenin
[no description available]		2.47203beta-sterol;
hexacyclic triterpenoid;
sapogenin;
spiroketal		antineoplastic agent;
antiviral agent;
apoptosis inducer;
metabolite
dioscin
[no description available]		2.9940hexacyclic triterpenoid;
spiroketal;
spirostanyl glycoside;
trisaccharide derivative		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 1.14.18.1 (tyrosinase) inhibitor;
hepatoprotective agent;
metabolite
deltonin
[no description available]		2.1510triterpenoid
furostanol i
furostanol I: from Dioscorea deltoidea; intermediate in in vivo diosgenin biosynthesis; structure given in first source. protodioscin : A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of 26-(beta-D-glucopyranosyloxy)-3beta,22-dihydroxyfurost-5-ene via a glycosidic linkage. Found in several plant species including yams, asparagus and funugreek.		2.3110beta-D-glucoside;
cyclic hemiketal;
pentacyclic triterpenoid;
steroid saponin;
trisaccharide derivative		metabolite
lyoniside
daucosterol : A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa.		2.1510beta-D-glucoside;
monosaccharide derivative;
steroid saponin		plant metabolite
1,7-bis(4-hydroxyphenyl)hepta-4E-6E-dien-3-one
1,7-bis(4-hydroxyphenyl)hepta-4E-6E-dien-3-one : A diarylheptanoid that is 4E-6E-dien-3-one substituted by 4-hydroxyphenyl group at positions 1 and 7. It has been isolated from the rhizomes of Curcuma kwangsiensis.		2.1510diarylheptanoid;
enone;
phenols		plant metabolite
diosgenin glucoside
diosgenin glucoside: RN given refers to (3beta,25R)-isomer; structure given in first source. diosgenin 3-O-beta-D-glucoside : A sterol 3-beta-D-glucoside having diosgenin as the sterol component.		2.0310hexacyclic triterpenoid;
monosaccharide derivative;
spiroketal;
sterol 3-beta-D-glucoside		metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0210
Extravascular Hemolysis
[description not available]		02.0310
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.0310
Malignant Melanoma
[description not available]		02.0410
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.0410
Cancer of Lung
[description not available]		02.1510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.1510
Benign Neoplasms, Brain
[description not available]		02.3110
Astrocytoma, Grade IV
[description not available]		02.3110
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		02.3110
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		02.3110