Page last updated: 2024-12-08
ci 943
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
CI 943: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 146009 |
| CHEMBL ID | 143865 |
| SCHEMBL ID | 10918513 |
| MeSH ID | M0169948 |
Synonyms (21)
| Synonym |
|---|
| ci-943 |
| 1h-imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine, 8-ethyl-7,8-dihydro-1,3,5-trimethyl- |
| 1h-imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine, 7,8-dihydro-8-ethyl-1,3,5-trimethyl- |
| ci 943 |
| 7,8-dihydro-8-ethyl-1,3,5-trimethyl-1h-imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine |
| CHEMBL143865 , |
| 7-ethyl-1,3,5-trimethyl-6,7-dihydro-1h-1,2,4,5a,8-pentaaza-as-indacene |
| bdbm50019968 |
| wuy06k900n , |
| 89239-35-0 |
| unii-wuy06k900n |
| SCHEMBL10918513 |
| 8-ethyl-1,3,5-trimethyl-7,8-dihydro-1h-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidine |
| ci-943, (+/-)- |
| 8-ethyl-7,8-dihydro-1,3,5-trimethyl-1h-imidazo-(1,2-c)pyrazolo(3,4-e)pyrimidine |
| HY-100161 |
| CS-0018157 |
| DTXSID80880064 |
| (+/-)-ci 943 |
| 11-ethyl-3,5,8-trimethyl-3,4,7,9,12-pentazatricyclo[7.3.0.02,6]dodeca-1(12),2(6),4,7-tetraene |
| AKOS040741549 |
Research Excerpts
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| " Treatment-related effects were evident for each behavioral parameter; they occurred at parentally toxic and nontoxic doses and in the absence of detrimental effects on offspring growth and development." | ( Developmental neurotoxicity of CI-943: a novel antipsychotic. Anderson, JA; Henck, JW; Petrere, JA, ) | 0.13 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (19)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID126467 | Inhibition of Sidman avoidance in squirrel monkeys after the compound administered through perorally | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID31387 | Displacement of [3H]CHA (N6-Cyclohexyl adenosine) from adenosine A1 receptor in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID61382 | Displacement of [3H]haloperidol from Dopamine receptor D2 in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID130897 | Inhibition of locomotor activity in mouse after intraperitoneal administration | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID40806 | Displacement of [3H]flunitrazepam from GABA-A benzodiazepine receptor of rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID177879 | Inhibition of Sidman avoidance in rats after peroral administration | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID141420 | Displacement of [3H]quinuclidinyl benzilate(QNB) from Muscarinic acetylcholine receptor in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID41351 | Displacement of [3H]DHA (Dihydroalprenolol) from beta-2 adrenergic receptor in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID36663 | Displacement of [3H]clonidine from alpha-2 adrenergic receptor in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID36590 | Displacement of [3H]WB-4101 from alpha-1 adrenergic receptor in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID95590 | Displacement of [3H]nitrendipine from L-type [Ca2+] channel of rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID178237 | Inhibition of self-stimulation in rats after the compound administered through perorally | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID61017 | Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID178242 | Inhibition of shelf-jump avoidance in rats after peroral administration. | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID178061 | Inhibition of locomotion in rats after the compound administered through perorally | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID5057 | Displacement of [3H]spiroperidol from 5-hydroxytryptamine 2 receptor in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID200921 | Displacement of [3H]5-HT from serotonin-1 neurotransmitter receptor in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID40398 | Displacement of [3H]DHA (Dihydroalprenolol) from beta-1 adrenergic receptor in rat brain | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| AID130893 | Inhibition of induction of ataxia in mouse after intraperitoneal administration | 1988 | Journal of medicinal chemistry, Feb, Volume: 31, Issue:2 | Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 25.22
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (25.22) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (11.11%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (88.89%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||