Page last updated: 2024-12-10

ay 23626

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Description

AY 23626: prostaglandin E2 agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3082469
CHEMBL ID3248898
SCHEMBL ID698122
MeSH IDM0152425

Synonyms (9)

Synonym
ay23626 ,
37786-01-9
ay-23626
prostan-1-oic acid, 15-hydroxy-9-oxo-, (15s)-
ay 23626
7-[(1r,2s)-2-[(3s)-3-hydroxyoctyl]-5-oxocyclopentyl]heptanoic acid
CHEMBL3248898
SCHEMBL698122
DTXSID90191234
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1145964Stimulation of prostanoid receptor-mediated cAMP accumulation in Charles River CD-1 mouse ovary at 25 ug/ml after 30 mins relative to control1977Journal of medicinal chemistry, Jan, Volume: 20, Issue:1
11,12-Secoprostaglandins. 2. N-acyl-N-alkyl-7-aminoheptanoic acids.
AID1135441Binding affinity to prostanoid receptor in [8-14C]adenine-treated CD-1 mouse ovary assessed as increase in c-AMP production at 50 ug/ml after 30 mins by paper chromatographic analysis in presence of phosphodiesterase inhibitor theophylline relative to con1977Journal of medicinal chemistry, Apr, Volume: 20, Issue:4
11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds.
AID1145963Stimulation of prostanoid receptor-mediated cAMP accumulation in Charles River CD-1 mouse ovary at 10 ug/ml after 30 mins relative to control1977Journal of medicinal chemistry, Jan, Volume: 20, Issue:1
11,12-Secoprostaglandins. 2. N-acyl-N-alkyl-7-aminoheptanoic acids.
AID1135435Binding affinity to prostanoid receptor in [8-14C]adenine-treated CD-1 mouse ovary assessed as increase in c-AMP production at 25 ug/ml after 30 mins by paper chromatographic analysis in presence of phosphodiesterase inhibitor theophylline relative to con1977Journal of medicinal chemistry, Apr, Volume: 20, Issue:4
11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds.
AID1145968Stimulation of prostanoid receptor-mediated cAMP accumulation in Charles River CD-1 mouse ovary at 1 ug/ml after 30 mins relative to control1977Journal of medicinal chemistry, Jan, Volume: 20, Issue:1
11,12-Secoprostaglandins. 2. N-acyl-N-alkyl-7-aminoheptanoic acids.
AID1135443Binding affinity to prostanoid receptor in rat lipocytes assessed as compound equivalent to cold PGE1 in displacing [3H]-PGE1 from receptor after 60 mins1977Journal of medicinal chemistry, Apr, Volume: 20, Issue:4
11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds.
AID1146115Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 25 ug/ml after 30 mins relative to control1977Journal of medicinal chemistry, Oct, Volume: 20, Issue:10
Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
AID1135440Binding affinity to prostanoid receptor in [8-14C]adenine-treated CD-1 mouse ovary assessed as increase in c-AMP production at 10 ug/ml after 30 mins by paper chromatographic analysis in presence of phosphodiesterase inhibitor theophylline relative to con1977Journal of medicinal chemistry, Apr, Volume: 20, Issue:4
11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds.
AID1146114Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 1 ug/ml after 30 mins relative to control1977Journal of medicinal chemistry, Oct, Volume: 20, Issue:10
Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
AID1135434Binding affinity to prostanoid receptor in [8-14C]adenine-treated CD-1 mouse ovary assessed as increase in c-AMP production at 1 ug/ml after 30 mins by paper chromatographic analysis in presence of phosphodiesterase inhibitor theophylline relative to cont1977Journal of medicinal chemistry, Apr, Volume: 20, Issue:4
11,12-Secoprostaglandins. 3. 8-Alkylthio(sulfinyl and sulfonyl)-12-hydroxyalkanoic acids and related compounds.
AID1146121Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 10 ug/ml after 30 mins relative to control1977Journal of medicinal chemistry, Oct, Volume: 20, Issue:10
Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
AID1146122Binding affinity to prostaglandin receptor in Charles River CD-1 mouse ovary assessed as increase in cAMP accumulation using [8-14C]adenine at 50 ug/ml after 30 mins relative to control1977Journal of medicinal chemistry, Oct, Volume: 20, Issue:10
Prostaglandin isosteres. 1. (8-Aza-, 8,10-diaza-, and 8-aza-11-thia)-9-oxoprostanoic acids and their derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.51 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.31 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]