apalcillin has been researched along with Escherichia-coli-Infections* in 1 studies
1 trial(s) available for apalcillin and Escherichia-coli-Infections
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Apalcillin treatment of complicated urinary tract infections.
In an open, prospective clinical trial, we evaluated the safety and efficacy of apalcillin in the treatment of complicated urinary tract infection. 21 hospitalized adult patients received apalcillin 2 g IV Q8-12 h for 5-17 days. There were 8 upper tract and 13 lower tract infections. Of 25 functional or anatomic abnormalities of the GU tract among these patients, 9 (36%) were corrected during the study period. Effectiveness of apalcillin was determined by clinical and bacteriologic response. 16 (76.2%) patients had clinical cures, 4 (19.8%) had clinical improvement, and 1 (4.8%) had clinical failure. Based on 26 pretreatment isolates, there were 16 (61.5%) bacteriologic cures and 10 (38.5%) failures. Failures were due to 6 (23.1%) relapses, 2 (7.7%) superinfections, and 2 (7.7%) relapses with superinfection. Adverse reactions were mild, transient, and did not require discontinuation of treatment. Apalcillin appears to be a safe, although marginally effective single agent antibiotic for the treatment of complicated urinary tract infections. Topics: Adult; Aged; Ampicillin; Clinical Trials as Topic; Escherichia coli Infections; Female; Humans; Middle Aged; Naphthyridines; Prospective Studies; Proteus Infections; Pseudomonas Infections; Recurrence; Urinary Tract Infections | 1987 |