Compounds > actinodaphine
Page last updated: 2024-11-07

actinodaphine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

actinodaphine: structure given in first source; isolated from Illigera SP [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

actinodaphnine : An organic heteropentacyclic compound 6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline bering additional hydroxy and methoxy substituents at positions 10 and 11 respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Illigeragenus[no description available]HernandiaceaeA plant family of the order Laurales, subclass Magnoliidae, class Magnoliopsida. Members contain cytotoxic furofuran LIGNANS and isoquinoline ALKALOIDS.[MeSH]

Cross-References

ID SourceID
PubMed CID160502
CHEMBL ID518088
CHEBI ID2444
SCHEMBL ID2450424
MeSH IDM0169204

Synonyms (21)

Synonym
CHEBI:2444 ,
(s)-11-methoxy-6,7,7a,8-tetrahydro-5h-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinolin-10-ol
1,2-methylenedioxy-9-hydroxy-10-methoxynoraporphine
(+)-actinodaphnine
actinodaphine
actinodaphnine
C09322
517-69-1
CHEMBL518088
actinodaphoine
227m8evc3t ,
5h-benzo(g)-1,3-benzodioxo(6,5,4-de)quinoline-10-ol, 6,7,7a,8-tetrahydro-1-methoxy-, (g)-
unii-227m8evc3t
5h-benzo(g)-1,3-benzodioxolo(6,5,4-de)quinolin-10-ol, 6,7,7a,8-tetrahydro-11-methoxy-, (7as)-
actinodaphnine [mi]
SCHEMBL2450424
Q27105670
DTXSID10965974
11-methoxy-6,7,7a,8-tetrahydro-2h,5h-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinolin-10-ol
(12s)-17-methoxy-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14,16,18-hexaen-16-ol
AKOS040763295

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (7)

RoleDescription
apoptosis inducerAny substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
topoisomerase inhibitorAn EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA).
antifungal agentAn antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
platelet aggregation inhibitorA drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
organic heteropentacyclic compound
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
secondary amino compoundA compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
aporphine alkaloidAny benzylisoquinoline alkaloid that has a structure based on 4H-dibenzo[de,g]quinoline or its 3-methyl derivative.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID403983Antiplatelet activity against collagen-induced rabbit platelet aggregation assessed as platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID398838Antiplatelet activity against arachidonic acid-induced rabbit platelet aggregation assessed as platelet aggregation at 5 ug/ml preincubated for 3 mins by turbidimetric method relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID376471Cytotoxicity against african green monkey Vero cells assessed as drug concentration at which no cellular alteration was microscopically detected1998Journal of natural products, Apr, Volume: 61, Issue:4
Antipoliovirus structure-activity relationships of some aporphine alkaloids.
AID401411Inhibition of collagen-induced platelet aggregation in rabbit platelet at 50 uM relative to control1998Journal of natural products, Jul, Volume: 61, Issue:7
Chemical constituents from Cassytha filiformis II.
AID398841Vasorelaxant activity against 3 uM norepinephrine -induced phasic contractions in rat thoracic aorta assessed as muscle contractions at 100 ug/mL pretreated for 15 mins before norepinephrine administration relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID401402Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet at 100 uM relative to control1998Journal of natural products, Jul, Volume: 61, Issue:7
Chemical constituents from Cassytha filiformis II.
AID403981Antiplatelet activity against ADP-induced rabbit platelet aggregation assessed as platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID376470Antiviral activity against Poliovirus 2 Sabin 2 in african green monkey Vero cells assessed as log reduction in virus titers after at 0.1 multiple round of replication at their respective maximum tolerated concentration after 32 hrs1998Journal of natural products, Apr, Volume: 61, Issue:4
Antipoliovirus structure-activity relationships of some aporphine alkaloids.
AID401410Inhibition of arachidonic acid-induced platelet aggregation in rabbit platelet at 50 uM relative to control1998Journal of natural products, Jul, Volume: 61, Issue:7
Chemical constituents from Cassytha filiformis II.
AID403982Antiplatelet activity against arachidonic acid-induced rabbit platelet aggregation assessed as platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID398836Antiplatelet activity against arachidonic acid-induced rabbit platelet aggregation assessed as platelet aggregation at 20 ug/ml preincubated for 3 mins by turbidimetric method relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID398843Vasorelaxant activity against 3 uM norepinephrine -induced tonic contractions in rat thoracic aorta assessed as muscle contractions at 100 ug/mL pretreated for 15 mins before norepinephrine administration relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID376475Antiviral activity against Poliovirus 2 Sabin 2 in african green monkey Vero cells assessed as log reduction in virus titers after at 0.001 multiple round of replication at their respective maximum tolerated concentration after 32 hrs1998Journal of natural products, Apr, Volume: 61, Issue:4
Antipoliovirus structure-activity relationships of some aporphine alkaloids.
AID398830Antiplatelet activity against PAF-induced rabbit platelet aggregation assessed as platelet aggregation at 100 ug/ml preincubated for 3 mins by turbidimetric method relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID398835Antiplatelet activity against arachidonic acid-induced rabbit platelet aggregation assessed as platelet aggregation at 50 ug/ml preincubated for 3 mins by turbidimetric method relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID401403Inhibition of collagen-induced platelet aggregation in rabbit platelet at 100 uM relative to control1998Journal of natural products, Jul, Volume: 61, Issue:7
Chemical constituents from Cassytha filiformis II.
AID398845Effect on resting tension in rat thoracic aorta at 100 ug/mL pretreated for 15 mins1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID401401Inhibition of ADP-induced platelet aggregation in rabbit platelet at 100 uM relative to control1998Journal of natural products, Jul, Volume: 61, Issue:7
Chemical constituents from Cassytha filiformis II.
AID376473Antiviral activity against Poliovirus 2 Sabin 2 in african green monkey Vero cells assessed as log reduction in virus titers after at 0.01 multiple round of replication at their respective maximum tolerated concentration after 32 hrs1998Journal of natural products, Apr, Volume: 61, Issue:4
Antipoliovirus structure-activity relationships of some aporphine alkaloids.
AID401412Inhibition of PAF-induced platelet aggregation in rabbit platelet at 50 uM relative to control1998Journal of natural products, Jul, Volume: 61, Issue:7
Chemical constituents from Cassytha filiformis II.
AID398839Vasorelaxant activity against 80 mM potassium-induced contractions in rat thoracic aorta assessed as muscle contractions at 100 ug/mL pretreated for 15 mins before potassium administration relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID401409Inhibition of ADP-induced platelet aggregation in rabbit platelet at 50 uM relative to control1998Journal of natural products, Jul, Volume: 61, Issue:7
Chemical constituents from Cassytha filiformis II.
AID401404Inhibition of PAF-induced platelet aggregation in rabbit platelet at 100 uM relative to control1998Journal of natural products, Jul, Volume: 61, Issue:7
Chemical constituents from Cassytha filiformis II.
AID398837Antiplatelet activity against arachidonic acid-induced rabbit platelet aggregation assessed as platelet aggregation at 10 ug/ml preincubated for 3 mins by turbidimetric method relative to control1997Journal of natural products, Jun, Volume: 60, Issue:6
Bioactive alkaloids from Illigera luzonensis.
AID376467Cytotoxicity against african green monkey Vero cells1998Journal of natural products, Apr, Volume: 61, Issue:4
Antipoliovirus structure-activity relationships of some aporphine alkaloids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's3 (42.86)18.2507
2000's1 (14.29)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.40 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.48 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		2.420benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
nifedipine
Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.		1.9910C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
prazosin
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.. prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.		1.9910aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
liriodenine
liriodenine: structure given in first source. liriodenine : An oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities.		2.420alkaloid antibiotic;
cyclic ketone;
organic heteropentacyclic compound;
oxacycle;
oxoaporphine alkaloid		antifungal agent;
antimicrobial agent;
antineoplastic agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite
boldine
[no description available]		1.9910aporphine alkaloid
bulbocapnine
bulbocapnine: was heading 1975-94 (Prov 1975-90); use APORPHINES to search BULBOCAPNINE 1975-94 (as Prov 1975-94); alkaloid from Corydalis cava and other plants; induces catalepsy probably due to its antagonism of DOPAMINE. bulbocapnine : An aporphine alkaloid that has been isolated from Corydalis and exhibits inhibitory activity against enzymes such as tyrosine 3-monooxygenase and diamine oxidase.		1.9910aporphine alkaloid;
aromatic ether;
oxacycle;
phenols		EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor;
EC 1.4.3.22 (diamine oxidase) inhibitor;
plant metabolite
n-methyllaurotetanine
N-methyllaurotetanine: structure in first source		1.9910
laurolitsine
laurolitsine: RN given for (S)-isomer; structure in first source. laurolistine : An aporphine alkaloid that is noraporphine substituted by hydroxy groups at positions 2 and 9 and methoxy groups at positions 1 and 10. Isolated from Litsea glutinosa and Lindera chunii, exhibits inhibitory activity against HIV-1 integrase.		1.9910aporphine alkaloid;
aromatic ether;
phenols		HIV-1 integrase inhibitor;
metabolite
laurotetanine
laurotetanine: isolated from Tetranthera & Lindera benzoin L. from family Lauraceae; structure		1.9910isoquinoline alkaloid
dicentrine
dicentrine: structure given in first source; RN refers to (S)-isomer		1.9910aporphine alkaloid
lysicamine
lysicamine: oxoaporphine alkaloid; structure in first source		1.9910alkaloid antibiotic;
oxoaporphine alkaloid		metabolite
dicentrinone
dicentrinone: from Ocotea leucoxylon; structure in first source		1.9910
n-methylactinodaphnine
N-methylactinodaphnine: isolated from Illigera luzonensis; structure given in first source		2.6930aporphine alkaloid
tamoxifen
[no description available]		7.1710stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		01.9910
Breast Cancer
[description not available]		07.1710
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.1710