10-methyl-9,10-dihydroacridine profile

10-methyl-9,10-dihydroacridine (10-MeDHA) is a chemical compound that belongs to the acridine family. It is structurally related to the well-known anti-malarial drug chloroquine and has attracted attention for its potential therapeutic applications.

**Structural features:**

* **Acridine core:** It contains the characteristic three-ringed acridine core, which gives the molecule its planar, aromatic structure.
* **Methyl group:** A methyl group is attached to the 10th carbon atom of the acridine ring.
* **Dihydro:** The molecule has two hydrogen atoms added to the 9th and 10th carbon atoms, resulting in a partially reduced ring system.

**Importance in research:**

10-MeDHA has shown promising activity in several research areas:

* **Anti-malarial activity:** It exhibits anti-malarial properties, potentially acting by interfering with the parasite's ability to digest heme, a crucial process in its survival. This suggests it could be a potential alternative or supplementary treatment for malaria.
* **Anti-cancer activity:** Studies have demonstrated that 10-MeDHA can inhibit the growth of certain cancer cell lines, including leukemia and breast cancer. It may achieve this by inducing apoptosis (programmed cell death) in cancer cells.
* **Anti-bacterial activity:** 10-MeDHA has been shown to possess antibacterial activity against various bacteria, including Staphylococcus aureus and Escherichia coli. This indicates it could be a potential candidate for the development of new antibiotics.
* **Anti-inflammatory activity:** Research has suggested that 10-MeDHA may have anti-inflammatory effects, potentially by modulating the activity of certain immune cells.

**Current research:**

Ongoing research is focused on understanding the precise mechanisms of action of 10-MeDHA and exploring its potential therapeutic applications. Scientists are investigating its pharmacokinetic properties, potential side effects, and its effectiveness in preclinical models of various diseases.

**Overall, 10-methyl-9,10-dihydroacridine is a promising compound with potential therapeutic benefits in various disease areas. However, further research is needed to determine its safety and efficacy before it can be considered for clinical use.**

10-methyl-9,10-dihydroacridine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	5324693
CHEMBL ID	2062588
SCHEMBL ID	975897
MeSH ID	M0458433

Synonym
10-methyl-9h-acridine
inchi=1/c14h13n/c1-15-13-8-4-2-6-11(13)10-12-7-3-5-9-14(12)15/h2-9h,10h2,1h
n-methylacridan
CHEMBL2062588
SCHEMBL975897
10-methyl-9,10-dihydroacridine
n-methyl-acridan

Assay ID	Title	Year	Journal	Article
AID673777	Cytotoxicity in UV-irradiated human U937 cells exposed to photosensitizer for 2 hrs before irradiation for 20 mins by WST-1 assay	2012	ACS medicinal chemistry letters, Apr-12, Volume: 3, Issue:4	Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	5 (62.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
benzene [no description available]	2.13	1	aromatic annulene; benzenes; volatile organic compound	carcinogenic agent; environmental contaminant; non-polar solvent
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.44	2	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
acridone acridone : A member of the class of acridines that is 9,10-dihydroacridine substituted by an oxo group at position 9.	2.07	1	acridines; cyclic ketone
nifedipine Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.	2.03	1	C-nitro compound; dihydropyridine; methyl ester	calcium channel blocker; human metabolite; tocolytic agent; vasodilator agent
nimodipine Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.. nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.	2.03	1	2-methoxyethyl ester; C-nitro compound; dicarboxylic acids and O-substituted derivatives; diester; dihydropyridine; isopropyl ester	antihypertensive agent; calcium channel blocker; cardiovascular drug; vasodilator agent
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	2.48	2	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
carbazole carbazole: structure in first source	2.07	1	carbazole
acridan [no description available]	2.07	1
phenothiazine 10H-phenothiazine : The 10H-tautomer of phenothiazine.	2.07	1	phenothiazine	ferroptosis inhibitor; plant metabolite; radical scavenger
cumene cumene : An alkylbenzene that is benzene carrying an isopropyl group.	2.03	1	alkylbenzene
styrene Styrene: A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.. styrene : A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.	2.03	1	styrenes; vinylarene; volatile organic compound	mouse metabolite; mutagen; plant metabolite
chloranil Chloranil: A quinone fungicide used for treatment of seeds and foliage.. tetrachloro-1,4-benzoquinone : A member of the class of 1,4-benzoquiones that is 1,4-benzoquinone in which all four hydrogens are substituted by chlorines.	2.04	1	1,4-benzoquinones; organochlorine compound	EC 2.7.1.33 (pantothenate kinase) inhibitor; metabolite
5H-dibenzo[b,f]azepine 5H-dibenzo[b,f]azepine : A mancude organic heterotricyclic parent that consists of a seven-membered nitrogen hetrocycle fused with two benzene rings.	2.07	1	dibenzoazepine; mancude organic heterotricyclic parent	marine xenobiotic metabolite
acridines Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.	3.44	7	acridines; mancude organic heterotricyclic parent; polycyclic heteroarene	genotoxin
hydrazine diamine : Any polyamine that contains two amino groups.	2.03	1	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
dibenzylamine 10,11-dihydro-5H-dibenzo(b,f)azepine: core structure of clomipramine	2.07	1
diphenylamine Diphenylamine: In humans it may be irritating to mucous membranes. Methemoglobinemia has been produced experimentally. In veterinary use, it is one of active ingredients in topical agents for prevention and treatment of screwworm infestation. An indicator in tests for nitrate poisoning.. diphenylamine : An aromatic amine containing two phenyl substituents. It has been used as a fungicide for the treatment of superficial scald in apples and pears, but is no longer approved for this purpose within the European Union.	2.07	1	aromatic amine; bridged diphenyl fungicide; secondary amino compound	antifungal agrochemical; antioxidant; carotogenesis inhibitor; EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor; ferroptosis inhibitor; radical scavenger
n-methylacridine N-methylacridine: RN given refers to acridinium parent cpd	2.13	1
phenoxazine phenoxazine: RN given refers to 10H-phenoxazine. 10H-phenoxazine : A member of the class of phenoxazines that is morpholine which is ortho-fused to two benzene rings at positions 2-3 and 5-6.	2.07	1	phenoxazine	ferroptosis inhibitor; radical scavenger
benzyldihydronicotinamide benzyldihydronicotinamide: structure	2.04	1
2,2,5,7,8-pentamethyl-1-hydroxychroman 2,2,5,7,8-pentamethyl-1-hydroxychroman: a Vitamin E derivative. chromanol : Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups.	2.03	1
1,4-dihydropyridine [no description available]	2.03	1
manganese(iii) porphyrin manganese(III) porphyrin: RN & N1 from 9th CI Form Index	2.1	1
dihydropyridines Dihydropyridines: Pyridine moieties which are partially saturated by the addition of two hydrogen atoms in any position.	2.03	1
1,1-diphenyl-2-picrylhydrazyl 1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)	2.03	1
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	2.97	4	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite

10-methyl-9,10-dihydroacridine

Description

Cross-References

Synonyms (7)

Bioassays (1)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.47

Study Types