Compounds > 7-ketodeoxycholic acid
Page last updated: 2024-12-08

7-ketodeoxycholic acid

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Description

7-ketodeoxycholic acid: RN given refers to (3 alpha,5 beta,12 alpha)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID188292
CHEMBL ID3392000
CHEBI ID16390
SCHEMBL ID1653937
MeSH IDM0081598

Synonyms (59)

Synonym
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanic acid
7-oxodeoxycholic acid
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid
3alpha,12alpha-diol-7-one-5beta-cholanoic acid
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid
7-ketodeoxycholic acid
(3alpha,5beta,12alpha)-3,12-dihydroxy-7-oxocholan-24-oic acid
911-40-0
CHEBI:16390 ,
3,12-dihydroxy-7-oxocholan-24-oic acid
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanoate
7-ketocholate
C04643
7-oxodeoxycholate
LMST04010184
(4r)-4-[(3r,5s,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
unii-14dep88bgs
3alpha,7alpha-dihydroxy-7-keto-5beta-cholanoic acid
14dep88bgs ,
7-keto-3alpha,12alpha-dihydroxycholanic acid;7-keto-3a,12-a-dihydroxycholanic acid;3a,12a-dihydroxy-7-keto-5?-cholan-24-oic acid
3a,12a-dihydroxy-7-oxo-5b-cholan-24-oic acid
3 alpha,7 alpha-dihydroxy-7-keto-5 beta-cholanoic acid
3 alpha,12 alpha-diol-7-one-5 beta-cholanoic acid
5.beta.-cholanic acid, 3.alpha.,12.alpha.-dihydroxy-7-oxo-
7-keto-deoxycholic acid
cholan-24-oic acid, 3,12-dihydroxy-7-oxo-, (3.alpha.,5.beta.,12.alpha.)-
5.beta.-cholan-24-oic acid, 3.alpha.,12.alpha.-dihydroxy-7-oxo-
SCHEMBL1653937
RHCPKKNRWFXMAT-RRWYKFPJSA-N
3alpha, 12alpha-dihydroxy-7-keto-5beta-cholanoic acid
cholan-24-oic acid, 3,12-dihydroxy-7-oxo-, (3a,5b,12a)-
7-keto-dca
CHEMBL3392000
AKOS027381854
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanoic acid
(r)-4-((3r,5s,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethyl-7-oxohexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid
3 alpha,7 alpha-dihydroxy-7-keto-5 beta-cholanoate
7-ketodeoxycholate
3 alpha,12 alpha-diol-7-one-5 beta-cholanoate
3a,12a-dihydroxy-7-oxo-5b-cholan-24-oate
(3a,5b,12a)-3,12-dihydroxy-7-oxo-cholan-24-oic acid
(3a,5b,12a)-3,12-dihydroxy-7-oxo-cholan-24-oate
AS-54739
5beta-cholanic acid-3alpha,12alpha-diol-7-one
mfcd00271373
Q27101883
A846728
7-keto-3alpha,12alpha-dihydroxycholanic acid;7-keto-3alpha,12-alpha-dihydroxycholanic acid;3alpha,12alpha-dihydroxy-7-keto-5beta-cholan-24-oic acid
V10233
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanic acid
7-keto-3 alpha ,12- alpha -dihydroxycholanic acid
(3alpha,5beta,12alpha)-3,12-dihydroxy-7-oxo-cholan-24-oic acid
7-keto-3?,12-?-dihydroxycholanic acid
7-keto-3 alpha ,12 alpha -dihydroxy-5 alpha -cholanic acid
7-keto-3alpha,12-alpha-dihydroxycholanic acid
DTXSID101314217
PD166097
CS-0016034
HY-41324
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
oxo-5beta-cholanic acid
7-oxo steroidAny oxo steroid carrying an oxo group at position 7.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's3 (30.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.98 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.98)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycine
[no description available]		1.9510alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
taurine
[no description available]		1.9510amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
chloroform
Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.		2.0710chloromethanes;
one-carbon compound		carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant
lithocholic acid
Lithocholic Acid: A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.. lithocholic acid : A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.. lithocholate : A bile acid anion that is the conjugate base of lithocholic acid.		3.0850bile acid;
C24-steroid;
monohydroxy-5beta-cholanic acid		geroprotector;
human metabolite;
mouse metabolite
chenodeoxycholic acid
Chenodeoxycholic Acid: A bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.. chenodeoxycholic acid : A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.. chenodeoxycholate : Conjugate base of chenodeoxycholic acid; major species at pH 7.3.		3.150bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid		human metabolite;
mouse metabolite
ursodeoxycholic acid
Ursodeoxycholic Acid: An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.. ursodeoxycholic acid : A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.. ursodeoxycholate : A bile acid anion that is the conjugate base of ursodeoxycholic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.		2.3920bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid		human metabolite;
mouse metabolite
3,7-dihydroxy-12-oxocholanoic acid
3,7-dihydroxy-12-oxocholanoic acid: RN given refers to (3alpha,5beta,7alpha)-isomer		2.3620oxo-5beta-cholanic acid
allocholic acid
allocholic acid: see also records for ursocholic and cholic acids. allocholic acid : An allo-bile acid that is 5alpha-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.		2.131012alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
allo-bile acid;
C24-steroid		human metabolite;
marine metabolite;
rat metabolite
cholic acid
Cholic Acid: A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.. cholic acid : A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.		3.155012alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid		human metabolite;
mouse metabolite
deoxycholic acid
Deoxycholic Acid: A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.. deoxycholic acid : A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.		3.690bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid		human blood serum metabolite
7-ketolithocholic acid
7-ketolithocholic acid: RN given refers to (3alpha,5beta)-isomer. 7-oxolithocholic acid : A bile acid that is lithocholic acid carrying an additional oxo substituent at position 7.		2.67303alpha-hydroxy steroid;
bile acid;
monohydroxy-5beta-cholanic acid;
oxo-5beta-cholanic acid		human metabolite
12-ketolithocholic acid
12-ketolithocholic acid: RN given refers to (3alpha,5beta)-isomer		1.9610bile acid
ConditionIndicatedRelationship StrengthStudiesTrials
Esophageal Varices
[description not available]		01.9610
Encephalopathy, Hepatic
[description not available]		01.9610
Cirrhosis, Liver
[description not available]		01.9610
Ascites
Accumulation or retention of free fluid within the peritoneal cavity.		01.9610
Esophageal and Gastric Varices
Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).		01.9610
Hepatic Encephalopathy
A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)		01.9610
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.		01.9610