| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
melatonin
[no description available] | 2.88 | 4 | 0 | acetamides;
tryptamines | anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger |
n-acetylserotonin
N-acetylserotonin : An N-acylserotonin resulting from the formal condensation of the primary amino group of serotonin with the carboxy group of acetic acid. | 1.99 | 1 | 0 | acetamides;
N-acylserotonin;
phenols | antioxidant;
human metabolite;
mouse metabolite;
tropomyosin-related kinase B receptor agonist |
6-chloromelatonin
[no description available] | 2.66 | 3 | 0 | acetamides | |
6-hydroxymelatonin
6-hydroxymelatonin : A member of the class of tryptamines that is melatonin with a hydroxy group substituent at position 6. | 1.99 | 1 | 0 | acetamides;
tryptamines | metabolite;
mouse metabolite |
chlorpromazine
Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.. chlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety. | 2.05 | 1 | 0 | organochlorine compound;
phenothiazines;
tertiary amine | anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug |
fendiline
Fendiline: Coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents. | 2.05 | 1 | 0 | diarylmethane | |
fluspirilene
Fluspirilene: A long-acting injectable antipsychotic agent used for chronic schizophrenia. | 2.05 | 1 | 0 | diarylmethane | |
raloxifene
raloxifene : A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively. | 2.05 | 1 | 0 | 1-benzothiophenes;
aromatic ketone;
N-oxyethylpiperidine;
phenols | bone density conservation agent;
estrogen antagonist;
estrogen receptor modulator |
sb 206553
SB 206553: a high-affinity 5-HT(2C/2B) antagonist; structure given in first source | 2.05 | 1 | 0 | pyrroloindole | |
methylergonovine
Methylergonovine: A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed) | 2.05 | 1 | 0 | ergoline alkaloid | |
n-acetyltryptamine
N-acetyltryptamine: antagonizes the melatonin-induced inhibition of dopamine release from retina; RN given refers to parent cpd. N-acetyltryptamine : A tryptamine compound having an acetyl substituent attached to the side-chain amino function. | 1.99 | 1 | 0 | acetamides;
indoles | |
adrenoglomerulotropin
adrenoglomerulotropin: aldosterone stimulating hormone found in extracts of pineal gland; structure | 2.05 | 1 | 0 | | |
N-Acetylhomoveratrylamine
[no description available] | 1.99 | 1 | 0 | acetamides | |
s20098
[no description available] | 1.99 | 1 | 0 | acetamides | |
10-hydroxycarbamazepine
10,11-dihydro-10-hydroxycarbamazepine: main metabolite of oxcarbazepine; structure given in first source. licarbazepine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine. | 2.05 | 1 | 0 | carboxamide;
dibenzoazepine;
ureas | anticonvulsant;
drug allergen;
sodium channel blocker |
2-iodomelatonin
[no description available] | 1.99 | 1 | 0 | acetamides | |
2-bromomelatonin
2-bromomelatonin: structure given in first source | 1.99 | 1 | 0 | | |
5-methoxyluzindole
[no description available] | 1.99 | 1 | 0 | | |
ah 001
AH 001: structure given in first source; a melatonin agonist | 1.99 | 1 | 0 | | |
bp 897
BP 897: a dopamine D3 receptor agonist; structure in first source | 2.05 | 1 | 0 | naphthalenecarboxamide | |
2-phenylmelatonin
[no description available] | 1.99 | 1 | 0 | phenylindole | |
8-methoxy-2-propionamidotetralin
8-methoxy-2-propionamidotetralin: enhances sperm hyperactivation via the MT1 receptor | 1.99 | 1 | 0 | tetralins | |
n-acetyl-4-aminomethyl-6-methoxy-9-methyl-1,2,3,4-tetrahydrocarbazole
N-acetyl-4-aminomethyl-6-methoxy-9-methyl-1,2,3,4-tetrahydrocarbazole: a melatonin receptor agonist; (-)-isomer is more active than the (+)-isomer; structure in first source | 1.99 | 1 | 0 | | |
pnu 96415e
[no description available] | 2.05 | 1 | 0 | piperazines | |
5-hydroxyethoxy-n-acetyltryptamine
5-hydroxyethoxy-N-acetyltryptamine: structure in first source | 1.99 | 1 | 0 | | |