8-methoxy-2-propionamidotetralin

Description

8-methoxy-2-propionamidotetralin: enhances sperm hyperactivation via the MT1 receptor [MeSH]

N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	5170952
CHEMBL ID	99377
SCHEMBL ID	55299
CHEBI ID	111166
MeSH ID	M0527904

Synonyms (28)

Synonym
CHEMBL99377 ,
n-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide
bdbm50045843
n-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propionamide
8-m-pdot
HMS3267A12
BRD-A07232941-001-01-9
PDSP2_001797
PDSP1_001814
NCGC00024954-02
CHEBI:111166
L005063
134865-70-6
SCHEMBL55299
AKOS022488635
m-pdot, 8-
ah 002
8-methoxy-2-propionamidotetralin
Q27190620
SR-01000597468-1
sr-01000597468
FT-0774238
HMS3676A17
HY-101358
CS-0021215
ah-002
HMS3412A17
MS-23343

Drug Classes (1)

Class	Description
tetralins	Compounds containing a tetralin skeleton.

Protein Targets (6)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	1.1220	AID2517
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	28.1838	AID485281
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	0.5973	AID504845
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	0.2239	AID504332

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Melatonin receptor type 1A	Homo sapiens (human)	IC50	0.0005	AID165366
Melatonin receptor type 1B	Homo sapiens (human)	IC50	0.0005	AID165366

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4 ISSN: 2211-1247	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID165366	Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.	1993	Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20 ISSN: 0022-2623	2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents.
AID107543	Binding affinity to compete for 2-[125I]iodomelatonin binding to chicken retinal membranes	1993	Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20 ISSN: 0022-2623	2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents.
AID107400	Negative logarithm of relative affinity (pRA) towards melatonin receptor (relative to N-acetyl-5-methoxytryptamine (aMT))	1998	Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 ISSN: 0022-2623	Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study.
AID107545	Relative binding affinity to chicken retinal membranes compared to 2-[125I]iodomelatonin.	1993	Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20 ISSN: 0022-2623	2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents.
AID165408	Relative potency of inhibition of calcium-dependent release of [3H]dopamine from rabbit retina caused by 2-[125I]iodomelatonin.	1993	Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20 ISSN: 0022-2623	2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents.

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (28.57)	18.2507
2000's	1 (14.29)	29.6817
2010's	2 (28.57)	24.3611
2020's	2 (28.57)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%

Substance	Classes	Roles	Relationship Strength
7-hydroxy-2-n,n-dipropylaminotetralin	tetralins		low
8-hydroxy-2-(di-n-propylamino)tetralin	phenols; tertiary amino compound; tetralins	serotonergic antagonist	low
2-(n-phenethyl-n-propyl)amino-5-hydroxytetralin	tetralins		low
am 580	amidobenzoic acid; tetralins	antineoplastic agent; retinoic acid receptor alpha/beta agonist	low
liranaftate	tetralins		low
nadolol	tetralins		low
tramazoline	tetralins		low
tetralin	ortho-fused bicyclic hydrocarbon; tetralins		low
6-Methoxy-1-tetralone	tetralins		low
2-aminotetralin	tetralins		low
be 2254	tetralins		low
5,6-dihydroxy-2-dimethylaminotetralin	tetralins		low
n 0437, (-)-isomer	tetralins		low
mibefradil	tetralins	T-type calcium channel blocker	low
5,6,7,8-tetrahydro-1-naphthol	tetralins		low
sertraline	dichlorobenzene; secondary amino compound; tetralins	antidepressant; serotonin uptake inhibitor	low
acetyl methyl tetramethyl tetralin	tetralins		low
tamibarotene	dicarboxylic acid monoamide; retinoid; tetralins	antineoplastic agent; retinoic acid receptor alpha/beta agonist	low
aj 76	secondary amino compound; tetralins	dopaminergic antagonist	low
oxoline	aromatic ketone; tetralins	geroprotector	low
lasofoxifene	aromatic ether; N-alkylpyrrolidine; naphthols; tetralins	antineoplastic agent; bone density conservation agent; cardioprotective agent; estrogen receptor agonist; estrogen receptor antagonist	low
isoshinanolone	tetralins		low
3-(4-chlorophenyl)-2-methyl-3,3a,4,5-tetrahydrobenzo[g]indazole	tetralins		low
N1-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide	tetralins		low
eptazocine	tetralins		low
1-(1H-imidazol-5-ylsulfonyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-piperidinecarboxamide	tetralins		low
4-oxo-4-[5-(1,2,3,4-tetrahydronaphthalen-1-ylsulfamoyl)-2,3-dihydroindol-1-yl]butanoic acid	tetralins		low
2-phenoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]acetamide	tetralins		low
1-(phenylmethyl)-3-(1,2,3,4-tetrahydronaphthalen-1-yl)thiourea	tetralins		low
4-phenyl-2-propionamidotetraline	tetralins		low
a 61603	tetralins		low
N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]cyclohexanecarboxamide	tetralins		low
2-chloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide	tetralins		low
2-(4-chlorophenoxy)-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]acetamide	tetralins		low
2,6-difluoro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide	tetralins		low
2,4-dichloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide	tetralins		low
sr 59230a	tetralins		low
7-hydroxy-2-(n-n-propyl-n-(3-iodo-2'-propenyl)-amino)tetralin	organoiodine compound; phenols; tertiary amino compound; tetralins	dopamine agonist	low
pseudopteroxazole	tetralins	metabolite	low
8-hydroxy-2-(di-n-propylamino)tetralin, (r)-isomer	tetralins		low
uh 232	tetralins		low
4-[(2,1,3-benzothiadiazol-4-ylsulfonylamino)methyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-cyclohexanecarboxamide	tetralins		low
nepicastat	1,3-dihydroimidazole-2-thiones; organofluorine compound; primary amino compound; tetralins	EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor	low
NNC 55-0396 (free base)	benzimidazoles; cyclopropanecarboxylate ester; organofluorine compound; tertiary amino compound; tetralins	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; neuroprotective agent; potassium channel blocker; T-type calcium channel blocker	low
(S)-Isosclerone	tetralins		low
PB28	aromatic ether; piperazines; tetralins	anticoronaviral agent; antineoplastic agent; apoptosis inducer; sigma-2 receptor agonist	low
(+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside	beta-D-glucoside; dimethoxybenzene; lignan; monosaccharide derivative; polyphenol; primary alcohol; tetralins	antibacterial agent; antifungal agent; metabolite	low
eptazocine hydrobromide	tetralins		low
lyoniresinol	dimethoxybenzene; lignan; polyphenol; primary alcohol; tetralins	antineoplastic agent; metabolite	low
N-[2-methyl-5-(2-thiazolo[5,4-b]pyridinyl)phenyl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide	tetralins		low
N-methyl-N-(3-pyridinylmethyl)-5-(5,6,7,8-tetrahydronaphthalen-2-yloxymethyl)-3-isoxazolecarboxamide	tetralins		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	1990's
melatonin	2	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger	1993	1998	28.5	low	2
n-acetylserotonin	1	acetamides; N-acylserotonin; phenols	antioxidant; human metabolite; mouse metabolite; tropomyosin-related kinase B receptor agonist	1998	1998	26.0	low	1
6-chloromelatonin	2	acetamides		1993	1998	28.5	low	2
6-hydroxymelatonin	1	acetamides; tryptamines	metabolite; mouse metabolite	1998	1998	26.0	low	1
6-fluoromelatonin	1			1998	1998	26.0	high	1
n-acetyl-2-phenylethylamine	1	N-acetyl-2-arylethylamine		1993	1993	31.0	medium	1
n-acetyltryptamine	1	acetamides; indoles		1998	1998	26.0	low	1
N-Acetylhomoveratrylamine	1	acetamides		1998	1998	26.0	high	1
s20098	1	acetamides		1998	1998	26.0	low	1
2-iodomelatonin	2	acetamides		1993	1998	28.5	low	2
2-bromomelatonin	1			1998	1998	26.0	medium	1
5-methoxyluzindole	1			1998	1998	26.0	high	1
N-[2-(4-methoxyphenyl)ethyl]acetamide	1	acetamides		1993	1993	31.0	medium	1
ah 001	2			1993	1998	28.5	high	2
2-phenylmelatonin	1	phenylindole		1998	1998	26.0	low	1
n-acetyl-4-aminomethyl-6-methoxy-9-methyl-1,2,3,4-tetrahydrocarbazole	1			1998	1998	26.0	medium	1
n-butanoyl-5-methoxytryptamine	1			1993	1993	31.0	high	1
5-hydroxyethoxy-n-acetyltryptamine	1			1998	1998	26.0	high	1

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	2000's	2010's
melatonin	2	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger	2008	2016	12.0	low	1	1
6-chloromelatonin	1	acetamides		2008	2008	16.0	low	1	0
rotenone	1	organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; mitochondrial NADH:ubiquinone reductase inhibitor; phytogenic insecticide; piscicide; toxin	2014	2014	10.0	low	0	1
2-iodomelatonin	1	acetamides		2008	2008	16.0	low	1	0
luzindole	1	acetamides; indoles	melatonin receptor antagonist	2008	2008	16.0	low	1	0
n-pentanoyl-2-benzyltryptamine	1	indoles		2008	2008	16.0	medium	1	0
4-phenyl-2-propionamidotetraline	3	tetralins		2008	2016	11.3	medium	1	2

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	2010's
Congenital Zika Syndrome	1	2020	2020	4.0	medium	1
Depression	1	2014	2014	10.0	medium	1
Disease Models, Animal	2	2014	2020	7.0	high	2
Inadequate Sleep	1	2014	2014	10.0	medium	1
Zika Virus Infection	1	2020	2020	4.0	medium	1

8-methoxy-2-propionamidotetralin

Description

Cross-References

Synonyms (28)

Drug Classes (1)

Protein Targets (6)

Potency Measurements

Inhibition Measurements

Bioassays (7)

Research

Studies (7)

Study Types

Related Drugs (72)

Drugs in this Class (51)

Drugs Involved in Assays Together (18)

Drugs Researched Together (7)

Related Conditions (5)