AH 001: structure given in first source; a melatonin agonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 3018920 |
| CHEMBL ID | 53015 |
| SCHEMBL ID | 3919777 |
| MeSH ID | M0222549 |
| Synonym |
|---|
| 2-amtt |
| 80270-68-4 |
| bdbm50035176 |
| 8-m-adot |
| n-(8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-acetamide |
| PDSP1_001813 |
| PDSP2_001796 |
| ah 001 |
| CHEMBL53015 , |
| n-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide |
| acetamide, n-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)- |
| 2-acetamido-8-methoxytetralin |
| 8-methoxy-2-acetamidotetralin |
| ah-001 |
| 153221-21-7 |
| ah001 |
| BCP9000251 |
| SCHEMBL3919777 |
| VDJCYVYVTWEIPD-UHFFFAOYSA-N |
| 8-methoxy-2-acetamido-tetralin |
| 2-acetylamino-8-methoxytetraline |
| n-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl) acetamide |
| m-adot, 8- |
| acetamide,n-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)- |
| 8-methoxy-2-acetamidotetraline |
| FT-0770383 |
| n-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)ethanimidic acid |
| DTXSID90934704 |
| BCP27637 |
| 2-amtt;2amtt;2 amtt;ah001;ah 001 |
| E98846 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Melatonin receptor type 1A | Homo sapiens (human) | IC50 (µMol) | 0.0014 | 0.0000 | 0.0640 | 1.0200 | AID165366 |
| Melatonin receptor type 1A | Gallus gallus (chicken) | Ki | 0.1251 | 0.0000 | 0.1687 | 0.8700 | AID107401; AID107546 |
| Melatonin receptor type 1B | Homo sapiens (human) | IC50 (µMol) | 0.0014 | 0.0000 | 0.3489 | 4.0000 | AID165366 |
| Melatonin receptor type 1C | Gallus gallus (chicken) | Ki | 0.1251 | 0.0000 | 0.1687 | 0.8700 | AID107401; AID107546 |
| Melatonin receptor type 1B | Gallus gallus (chicken) | Ki | 0.1371 | 0.0000 | 0.1617 | 0.8700 | AID107401; AID107546; AID222168 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | Melatonin receptor type 1A | Homo sapiens (human) |
| receptor complex | Melatonin receptor type 1A | Homo sapiens (human) |
| plasma membrane | Melatonin receptor type 1A | Homo sapiens (human) |
| receptor complex | Melatonin receptor type 1A | Gallus gallus (chicken) |
| plasma membrane | Melatonin receptor type 1A | Gallus gallus (chicken) |
| plasma membrane | Melatonin receptor type 1B | Homo sapiens (human) |
| synapse | Melatonin receptor type 1B | Homo sapiens (human) |
| plasma membrane | Melatonin receptor type 1B | Homo sapiens (human) |
| nucleoplasm | Melatonin receptor type 1C | Gallus gallus (chicken) |
| plasma membrane | Melatonin receptor type 1C | Gallus gallus (chicken) |
| plasma membrane | Melatonin receptor type 1B | Gallus gallus (chicken) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID107542 | In vitro binding affinity against melatonin receptor using 2-[125I]iodomelatonin (0.05 nM) and chicken brain membranes | 1996 | Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16 | Synthesis of 2-amido-2,3-dihydro-1H-phenalene derivatives as new conformationally restricted ligands for melatonin receptors. |
| AID107543 | Binding affinity to compete for 2-[125I]iodomelatonin binding to chicken retinal membranes | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20 | 2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents. |
| AID107401 | Binding affinity towards melatonin receptor in chicken brain. | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9 | Mapping the melatonin receptor. 4. Comparison of the binding affinities of a series of substituted phenylalkyl amides. |
| AID222168 | Binding affinity measured against Chicken brain melatonin receptor by using 2-[125I]iodomelatonin as radioligand | 1998 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 8, Issue:23 | Synthesis of benzocycloalkane derivatives as new conformationally restricted ligands for melatonin receptors. |
| AID107400 | Negative logarithm of relative affinity (pRA) towards melatonin receptor (relative to N-acetyl-5-methoxytryptamine (aMT)) | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 | Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study. |
| AID165366 | Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina. | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20 | 2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents. |
| AID107539 | Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes | 1995 | Journal of medicinal chemistry, Jun-09, Volume: 38, Issue:12 | Design and synthesis of new naphthalenic derivatives as ligands for 2-[125I]iodomelatonin binding sites. |
| AID165408 | Relative potency of inhibition of calcium-dependent release of [3H]dopamine from rabbit retina caused by 2-[125I]iodomelatonin. | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20 | 2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents. |
| AID107545 | Relative binding affinity to chicken retinal membranes compared to 2-[125I]iodomelatonin. | 1993 | Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20 | 2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents. |
| AID107546 | Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5 | Three-dimensional quantitative structure-activity relationship of melatonin receptor ligands: a comparative molecular field analysis study. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (31.08) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||