| Assay ID | Title | Year | Journal | Article |
|---|
| AID354813 | Antimicrobial activity against Enterococcus faecalis ATCC 29212 after 16 hrs by disk susceptibility test | 1996 | Journal of natural products, Oct, Volume: 59, Issue:10
| Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta. |
| AID354814 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 16 hrs by disk susceptibility test | 1996 | Journal of natural products, Oct, Volume: 59, Issue:10
| Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta. |
| AID349212 | Activity at RYR2 receptor in rat cerebellar granule neurons assessed activation of [45Ca2+] uptake at 20 uM after 10 mins | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21
| Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons. |
| AID266719 | Agonist like activity at skeletal junction sarcoplasmic reticulum RyR1/FKBP12 complex assessed as increase in [3H]ryanodine binding | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complex. |
| AID349211 | Activity at RYR2 receptor in rat cerebellar granule neurons assessed as increase in intracellular calcium level at 20 uM | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21
| Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons. |
| AID334201 | Displacement of [3H]ryanodine from RyR1 calcium channel in sarcoplasmic reticulum assessed as calcium mobilization | 2003 | Journal of natural products, Jan, Volume: 66, Issue:1
| Cationic reduction of bastadin-4 to bastadin-5. Preparation of 5-[2h]-bastadin-5 by site-specific isotopic labeling. |
| AID1255367 | Cytotoxicity against human MDM cells at 5 uM after 24 hrs | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages. |
| AID1255366 | Inhibition of ACAT in human MDM cells assessed as inhibition of foam cell formation by measuring acetylated LDL-induced [3H]cholesterol ester accumulation at 5 uM after 24 hrs in presence of 0.1 mM [3H]oleate | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages. |
| AID354812 | Antimicrobial activity against Neisseria gonorrhoeae ATCC 49226 after 16 hrs by disk susceptibility test | 1996 | Journal of natural products, Oct, Volume: 59, Issue:10
| Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta. |
| AID1255369 | Inhibition of human ACAT2 expressed in CHO cells assessed as inhibition of [3H]cholesterol ester accumulation at 5 uM in presence of 0.1 mM [3H]oleate-conjugated BSA | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages. |
| AID349210 | Binding affinity to RYR1 channels by calcium mobilization assay | 2008 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 18, Issue:21
| Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons. |
| AID463756 | Antitrypanosomal activity against Trypanosoma brucei brucei 221 after 48 hrs by ATP-bioluminescence assay | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Additional insights on the bastadins: isolation of analogues from the sponge Ianthella cf. reticulata and exploration of the oxime configurations. |
| AID463757 | Cytotoxicity against human HCT116 cells after 7 days by methylene blue staining | 2010 | Journal of natural products, Mar-26, Volume: 73, Issue:3
| Additional insights on the bastadins: isolation of analogues from the sponge Ianthella cf. reticulata and exploration of the oxime configurations. |
| AID354816 | Antimicrobial activity against Cryptococcus neoformans ATCC 90112 up to 100 ug/disk after 42 hrs by disk susceptibility test | 1996 | Journal of natural products, Oct, Volume: 59, Issue:10
| Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta. |
| AID355165 | Displacement of [3H]ryanodine from Ry1R/FKBP12 receptor complex in rabbit sarcoplasmic reticulum | 1996 | Journal of natural products, Dec, Volume: 59, Issue:12
| Bastadin 20 and bastadin O-sulfate esters from Ianthella basta: novel modulators of the Ry1R FKBP12 receptor complex. |
| AID1255368 | Inhibition of human ACAT1 expressed in CHO cells assessed as inhibition of [3H]cholesterol ester accumulation at 5 uM in presence of 0.1 mM [3H]oleate-conjugated BSA | 2015 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
| Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages. |
| AID354815 | Antimicrobial activity against Candida albicans ATCC 90028 up to 100 ug/disk after 42 hrs by disk susceptibility test | 1996 | Journal of natural products, Oct, Volume: 59, Issue:10
| Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |