| ID Source | ID |
|---|---|
| PubMed CID | 45484303 |
| CHEMBL ID | 565540 |
| CHEMBL ID | 1084615 |
| SCHEMBL ID | 676043 |
| MeSH ID | M0535882 |
| Synonym |
|---|
| sen-12333 |
| CHEMBL565540 , |
| way-317538 |
| CHEMBL1084615 , |
| 5-morpholin-4-ylpentanoic acid(4-pyridin-3-ylphenyl)amide hydrochloride |
| bdbm50300802 |
| n-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide |
| way 317538 |
| 874450-44-9 |
| sen 12333 |
| SCHEMBL676043 |
| AKOS024458162 |
| DTXSID30670437 |
| 5-(morpholin-4-yl)-n-[4-(pyridin-3-yl)phenyl]pentanamide |
| 5-morpholin-4-yl-pentanoic acid (4-pyridin-3-yl-phenyl)-amide |
| NCGC00379128-01 |
| 5-(4-morpholinyl)-n-(4-(3-pyridyl)phenyl)pentanamide |
| XCHIZTUBUXZESJ-UHFFFAOYSA-N , |
| 4-morpholinepentanamide, n-(4-(3-pyridinyl)phenyl)- |
| M92TU1EZ75 , |
| n-(4-(3-pyridinyl)phenyl)-4-morpholinepentanamide |
| unii-m92tu1ez75 |
| EX-A3487 |
| 5-morpholin-4-yl-n-(4-pyridin-3-ylphenyl)pentanamide |
| MS-25175 |
| HY-107678 |
| sen12333 |
| 5-morpholino-n-(4-(pyridin-3-yl)phenyl)pentanamide , |
| BS171067 |
| CS-0029164 |
| F88156 |
| AC-36424 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 21.3174 | AID1645841 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 6.0081 | AID1645840 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | AID1183536; AID1203762; AID654105 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | AID1183535; AID1203761; AID654104 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | AID1183535; AID1203761; AID654104 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | AID1183536; AID1203762; AID654105 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Ki | 0.6133 | AID1183534; AID1203760; AID654106 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | EC50 | 9.3912 | AID1183537; AID1203763; AID1203764; AID483822; AID654106; AID654108 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 ISSN: 2472-5560 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1203765 | Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by patch-clamp electrophysiology assay relative to acetylcholine | 2015 | European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254 | Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs. |
| AID1203762 | Displacement of [3H]epibatidine from rat alpha3beta4 nAChR transfected in HEK293 cells by liquid scintillation counting | 2015 | European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254 | Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs. |
| AID1183537 | Agonist activity at rat nAChR alpha7 expressed in GH4C1 cells by fluorescent calcium assay | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84ISSN: 1768-3254 | Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333. |
| AID654107 | Partial agonist activity at wild type rat alpha7 nAChR expressed in Xenopus oocyte by voltage clamp electrophysiology assay relative to acetylcholine | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7 ISSN: 1464-3405 | Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. |
| AID654105 | Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 4 hrs by liquid scintillation counting | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7 ISSN: 1464-3405 | Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. |
| AID1203764 | Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by patch-clamp electrophysiology assay | 2015 | European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254 | Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs. |
| AID654104 | Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 4 hrs by liquid scintillation counting | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7 ISSN: 1464-3405 | Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. |
| AID1203760 | Displacement of [3H]epibatidine from rat alpha7 nAChR transfected in HEK293 cells by liquid scintillation counting | 2015 | European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254 | Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs. |
| AID1183534 | Displacement of [3H]EB from rat nAChR alpha7 expressed in HEK293 cell membranes by liquid scintillation counting | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84ISSN: 1768-3254 | Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333. |
| AID654106 | Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in HEK292 cells after 4 hrs by liquid scintillation counting | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7 ISSN: 1464-3405 | Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. |
| AID1183536 | Displacement of [3H]EB from rat nAChR alpha3beta4 expressed in HEK293 cell membranes by liquid scintillation counting | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84ISSN: 1768-3254 | Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333. |
| AID654108 | Partial agonist activity at wild type rat recombinant alpha7 nAChR expressed in Xenopus oocyte by voltage clamp electrophysiology assay | 2012 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 22, Issue:7 ISSN: 1464-3405 | Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. |
| AID1203761 | Displacement of [3H]epibatidine from rat alpha4beta2 nAChR transfected in HEK293 cells by liquid scintillation counting | 2015 | European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254 | Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs. |
| AID1203763 | Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by fluorescent calcium assay | 2015 | European journal of medicinal chemistry, May-05, Volume: 95ISSN: 1768-3254 | Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs. |
| AID1183535 | Displacement of [3H]EB from rat nAChR alpha4beta2 expressed in HEK293 cell membranes by liquid scintillation counting | 2014 | European journal of medicinal chemistry, Sep-12, Volume: 84ISSN: 1768-3254 | Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333. |
| AID483822 | Agonist activity at rat alpha7 nAChR expressed in rat GH4C1 cells assessed as calcium flux by FLIPR | 2010 | Journal of medicinal chemistry, Jun-10, Volume: 53, Issue:11 ISSN: 1520-4804 | Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE- |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Congenital Zika Syndrome | 0 | 2020 | 2020 | 4.0 | high | 0 | 0 | 0 | 0 | 1 | 0 | |
| Disease Models, Animal | 0 | 2020 | 2020 | 4.0 | high | 0 | 0 | 0 | 0 | 1 | 0 | |
| Zika Virus Infection | 0 | 2020 | 2020 | 4.0 | high | 0 | 0 | 0 | 0 | 1 | 0 |
| Article | Year |
|---|---|
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, , Volume: 96, Issue:5 | 2019 |
| Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE- Journal of medicinal chemistry, , Jun-10, Volume: 53, Issue:11 | 2010 |