Compounds > 3-(3,5-dimethyl-1-pyrazolyl)-5-phenyl-1,2,4-triazine
Page last updated: 2024-08-01 14:21:24

3-(3,5-dimethyl-1-pyrazolyl)-5-phenyl-1,2,4-triazine

Description

3-(3,5-dimethyl-1-pyrazolyl)-5-phenyl-1,2,4-triazine : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID5310871
CHEMBL ID1412093
CHEBI ID107354

Synonyms (12)

Synonym
CHEMDIV3_006665
IDI1_024575
smr000104023
MLS000108060 ,
CHEBI:107354
BRD-K65567793-001-01-4
HMS1491O21
3-(3,5-dimethylpyrazol-1-yl)-5-phenyl-1,2,4-triazine
HMS2173H10
CHEMBL1412093
Q27185655
3-(3,5-dimethyl-1-pyrazolyl)-5-phenyl-1,2,4-triazine

Drug Classes (1)

ClassDescription
1,2,4-triazinesAny compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure.

Protein Targets (19)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Chain A, Ferritin light chainEquus caballus (horse)Potency19.9526AID485281
LuciferasePhotinus pyralis (common eastern firefly)Potency33.8078AID588342
glp-1 receptor, partialHomo sapiens (human)Potency31.6228AID624417
ATAD5 protein, partialHomo sapiens (human)Potency6.0498AID504466; AID504467
Microtubule-associated protein tauHomo sapiens (human)Potency39.8107AID1460
glucocerebrosidaseHomo sapiens (human)Potency0.2512AID2101
luciferasePhoturis pensylvanica (Pennsylania firefly)Potency19.9526AID1379
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency50.1187AID504333
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency79.4328AID504332
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency56.2341AID1466; AID2242
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency3.1623AID485313
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency28.1838AID894
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency4.2240AID2546; AID2551
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency31.6228AID485360
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency12.5893AID2675
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency56.2341AID1466
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)Potency56.2341AID1466
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency6.3096AID901
TAR DNA-binding protein 43Homo sapiens (human)Potency11.2202AID652104

Bioassays (9)

Assay IDTitleYearJournalArticle
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
ISSN: 1872-9096		High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
ISSN: 1464-3405		Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
lamotrigine
0
1,2,4-triazines;
dichlorobenzene;
primary arylamine		anticonvulsant;
antidepressant;
antimanic drug;
calcium channel blocker;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
excitatory amino acid antagonist;
geroprotector;
non-narcotic analgesic;
xenobiotic		00low000000
metribuzin
0
1,2,4-triazines;
cyclic ketone;
organic sulfide		agrochemical;
environmental contaminant;
herbicide;
xenobiotic		00low000000
metamitron
0
1,2,4-triazinesenvironmental contaminant;
herbicide;
xenobiotic		00low000000
1,2,4-triazine
0
1,2,4-triazines;
triazine		00low000000
azauracil
0
1,2,4-triazines;
nucleobase analogue		antimetabolite00low000000
6-azathymine
0
1,2,4-triazines;
cyclic ketone;
nucleobase analogue		EC 2.6.1.40 [(R)-3-amino-2-methylpropionate--pyruvate transaminase] inhibitor;
Mycoplasma genitalium metabolite		00low000000
3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine
0
1,2,4-triazines00low000000
Benzo[E]pyrazolo[5,1-c][1,2,4]triazin-8-yl N,N-dimethylcarbamate
0
1,2,4-triazines00low000000
3-(2,5-dimethyl-3-furanyl)-5,6-diphenyl-1,2,4-triazine
0
1,2,4-triazines00low000000
ceftriaxone
0
1,2,4-triazines;
1,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen;
EC 3.5.2.6 (beta-lactamase) inhibitor		00low000000
5,6-diphenyl-3-pyridin-4-yl-1,2,4-triazine
0
1,2,4-triazines00low000000
pymetrozine
0
1,2,4-triazines;
pyridines		antifeedant;
environmental contaminant;
TRPV channel modulator;
xenobiotic		00low000000
ml228 probe
0
1,2,4-triazines;
biphenyls;
pyridines;
secondary amino compound		hypoxia-inducible factor pathway activator00low000000
6-methyl-3-sulfanylidene-1,2-dihydro-[1,2,4]triazolo[4,3-b][1,2,4]triazin-7-one
0
1,2,4-triazines00low000000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Encephalitis, Polio0
1
2011201113.0high000010
Inflammation0
1
2010201014.0high000100
Innate Inflammatory Response0
1
2010201014.0high000100
Poliomyelitis0
1
2011201113.0high000010